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Cited by 341Ovarian function and disordersSexual Differentiation and DisordersHypothalamic control of reproductive hormones

Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism

Ibañez, L, Potau, N, Virdis, R, Zampolli, M, Terzi, C, Gussinyé, M, Carrascosa, A, Vicens-Calvet, E·1993·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.76.6.8501168
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Abstract

The postpubertal outcome of a group of girls diagnosed of premature pubarche during childhood was assessed 1) to determine the incidence of functional ovarian hyperandrogenism (FOH) through the ovarian-steroidogenic response to the GnRH agonist leuprolide acetate, 2) to validate leuprolide acetate stimulation in FOH diagnosis, and 3) to ascertain whether FOH-predictive biochemical markers exist at the diagnosis of premature pubarche. Of 35 patients (age, 15.4 +/- 1.5 yr), 16 showed hirsutism, oligomenorrhea, and elevated baseline testosterone and/or androstenedione (delta 4-A) levels. Subcutaneous administration of leuprolide acetate (500 micrograms) produced similar increases in gonadotropin levels in oligomenorrheic patients, regularly menstruating patients (n = 19), and controls (n = 12; age, 15.3 +/- 1.3 yr) when tested at 6 h. Of all of the steroids measured, 17-hydroxyprogesterone (17-OHP) and delta 4-A levels 24 h postleuprolide acetate stimulation were significantly higher in oligomenorrheic patients than in the other two groups (P < 0.0001). No overlapping in 17-OHP responses occurred between oligomenorrheic patients and the other groups. Baseline dehydroepiandrosterone sulfate and delta 4-A levels at the diagnosis of premature pubarche correlated with 17-OHP values postleuprolide acetate challenge (r = 0.47; P < 0.005 and r = 0.67; P < 0.0001, respectively). These results show a distinct leuprolide acetate challenge response in 45% of the postpubertal premature puba…

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Crossref · 10.1210/jcem.76.6.8501168

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  • Premature and exaggerated adrenarche may be associated with insulin resistance, and girls with premature exaggerated adrenarche appear to be at much higher risk of developing the polycystic ovary syndrome as adults, and infants born small for gestational age may be at increased risk.

    “Premature and exaggerated adrenarche may be associated with insulin resistance, and girls with premature exaggerated adrenarche appear to be at much higher risk of developing the polycystic ovary syndrome as adults (characterized by hyperandrogenism, fewer ovulatory cycles, insulin resistance, and hypertriglyceridemia) (729 -731), and infants born small for gestational age may be at increased risk”

    From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [729]

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Authors
Ibañez, L., Potau, N., Virdis, R., Zampolli, M., Terzi, C., Gussinyé, M., Carrascosa, A., & Vicens-Calvet, E.
Affiliations
Universitat Autònoma de Barcelona (ES)
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1993-06
Volume
76
Issue
6
Pages
1599-1603
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.76.6.8501168
OpenAlex
W2106399685
Cited by
341
References
1
Citations by year
2026: 2 · 2025: 7 · 2024: 8 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 12
FWCI
6.90
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
premature pubarche, 17-hydroxyprogesterone, ovarian steroidogenesis, hyperandrogenism, oligomenorrhea, hirsutism, dehydroepiandrosterone sulfate, androstenedione, girls, diagnostic biomarkers, hyperandrogenemia
MeSH terms
Androgens, Female, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Ovarian Diseases, Ovary, Puberty, Puberty, Precocious, Retrospective Studies, Steroids, Incidence, Leuprolide

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