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Cited by 329

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Elimination of Coincident Staphylococcus aureus Nasal and Hand Carriage with Intranasal Application of Mupirocin Calcium Ointment

Reagan, David R., Doebbeling, Bradley N., Pfaller, Michael A., Sheetz, Carol T., Houston, Alison K., Hollis, Richard J., Wenzel, Richard P.·1991·Annals of Internal Medicine
DOI 10.7326/0003-4819-114-2-101
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Abstract

OBJECTIVE: To determine the safety and efficacy of mupirocin calcium ointment in the elimination of Staphylococcus aureus nasal and hand carriage in healthy persons. DESIGN: A double-blind, placebo-controlled, randomized trial. SETTING: Clinical research unit of a tertiary medical center. SUBJECTS: Health care workers with stable S. aureus nasal carriage. INTERVENTIONS: Subjects (n = 68) were randomly assigned to receive either mupirocin or placebo intranasally twice daily for 5 days. MEASUREMENTS AND MAIN RESULTS: Cultures of the hands and nares were obtained at baseline and 72 hours after therapy. The nares were also cultured 1, 2, 4, and 12 weeks after therapy. Antimicrobial susceptibility testing and restriction endonuclease analysis of plasmid DNA were used to confirm strain identity. There were no serious side effects. Mupirocin decreased the frequency of S. aureus nasal carriage at each time interval: At 3 months, 71% of subjects receiving mupirocin remained free of nasal S. aureus compared with 18% of controls. This difference (53%; 95% CI; 26% to 80%) was significant (P less than 0.0001). Additionally, analysis of plasmid patterns showed that 79% of subjects in the mupirocin group were free of the initial colonizing strain at 3 months. The proportion of hand cultures positive for S. aureus in the mupirocin group after therapy was lower than in the placebo group (2.9% compared with 57.6%). This difference (53%; 95 CI, 30% to 80%) was significant, after adjustment for the frequency of hand carriage at baseline (P less than 0.0001). CONCLUSIONS: When applied intranasally for 5 days, mupirocin calcium ointment is safe and effective in eliminating S. aureus nasal carriage in healthy persons for up to 3 months and appears to have a corresponding effect on hand carriage at 72 hours after therapy.

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Metadata

Authors
Reagan, D. R., Doebbeling, B. N., Pfaller, M. A., Sheetz, C. T., Houston, A. K., Hollis, R. J., & Wenzel, R. P.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1991-01-15
Volume
114
Issue
2
Pages
101-106
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-114-2-101
OpenAlex
W2085339757
Cited by
329
References
19
FWCI
15.61
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Elimination of Coincident Staphylococcus aureus Nasal and Hand Carriage with Intranasal Application of Mupirocin Calcium Ointment. https://app.cochat.ai/papers/10.7326/0003-4819-114-2-101
The paper
Reagan, D. R., Doebbeling, B. N., Pfaller, M. A., Sheetz, C. T., Houston, A. K., Hollis, R. J., & Wenzel, R. P. (1991). Elimination of Coincident Staphylococcus aureus Nasal and Hand Carriage with Intranasal Application of Mupirocin Calcium Ointment. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-114-2-101

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