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Cited by 127Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The Natural History of Lone Atrial Flutter

Halligan, Sean C., Gersh, Bernard J., Brown, Robert D., Rosales, A. Gabriela, Munger, Thomas M., Shen, Win-Kuang, Hammill, Stephen C., Friedman, Paul A.·2004·Annals of Internal Medicine
DOI 10.7326/0003-4819-140-4-200402170-00008
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Abstract

BACKGROUND: The natural history of atrial flutter is not well defined. OBJECTIVE: To report the risk for stroke, conversion to atrial fibrillation, and anticoagulation for lone atrial flutter. DESIGN: Retrospective cohort analysis. SETTING: A clinically based longitudinal study of inpatients and outpatients with atrial flutter. PATIENTS: The authors compared the stroke rate in 59 patients with atrial flutter with rates in a sample in which age- and sex-specific ischemic cerebrovascular event rates were determined and in a sample of nonhypertensive patients with lone atrial fibrillation. The risk for developing atrial fibrillation after presenting with atrial flutter is also reported. MEASUREMENTS: Electrocardiograms and clinical data were collected and reviewed for each study participant. RESULTS: After adjustment for age and sex, patients with atrial flutter had a higher incidence of thromboembolic events than the sample control patients and patients with atrial fibrillation. Atrial fibrillation developed in 56% of patients with atrial flutter. CONCLUSIONS: Lone atrial flutter has a stroke risk at least as high as lone atrial fibrillation and carries a higher risk for subsequent development of atrial fibrillation than in the general population. Anticoagulation should be considered for all patients with atrial flutter who are older than 65 years of age.

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Crossref · 10.7326/0003-4819-140-4-200402170-00008

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Metadata

Authors
Halligan, S. C., Gersh, B. J., Brown, R. D., Rosales, A. G., Munger, T. M., Shen, W.-K., Hammill, S. C., & Friedman, P. A.
Affiliations
Mayo Clinic (US)
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2004-02-17
Volume
140
Issue
4
Pages
265-268
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-140-4-200402170-00008
OpenAlex
W2007242746
Cited by
127
References
7
Citations by year
2025: 1 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 6 · 2016: 6 · 2015: 11 · 2014: 4 · 2013: 4 · 2012: 6
FWCI
6.74
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
natural history (disease), stroke risk, thromboembolism, anticoagulation, atrial fibrillation, cerebral ischemic events, elderly patients
MeSH terms
Adult, Aged, Aged, 80 and over, Anticoagulants, Atrial Fibrillation, Atrial Flutter, Humans, Longitudinal Studies, Middle Aged, Retrospective Studies, Risk Factors, Thromboembolism, Cohort Studies, Matched-Pair Analysis, Stroke

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CoChat. (2026). Citation check: The Natural History of Lone Atrial Flutter. https://app.cochat.ai/papers/10.7326/0003-4819-140-4-200402170-00008
The paper
Halligan, S. C., Gersh, B. J., Brown, R. D., Rosales, A. G., Munger, T. M., Shen, W.-K., Hammill, S. C., & Friedman, P. A. (2004). The Natural History of Lone Atrial Flutter. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-140-4-200402170-00008