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Cited by 7HIV-related health complications and treatmentsDiabetes, Cardiovascular Risks, and LipoproteinsPeroxisome Proliferator-Activated Receptors

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Comparison of Rosiglitazone and Metformin for Treating HIV Lipodystrophy: A Randomized Trial

van Wijk, Jeroen P.H., de Koning, Eelco J.P., Cabezas, Manuel Castro, op't Roodt, Jos, Joven, Jorge, Rabelink, Ton J., Hoepelman, Andy I.·2005·Annals of Internal Medicine
DOI 10.7326/0003-4819-143-5-200509060-00009
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Abstract

Background: The use of antiretroviral combination therapy in HIV has been associated with lipodystrophy and cardiovascular risk factors. Objective: To compare the effects of the peroxisome proliferator–activated receptor-γ agonist rosiglitazone and metformin for treating HIV lipodystrophy. Design: An open, randomized, 6-month clinical trial. Setting: University Medical Center, Utrecht, the Netherlands. Patients: 39 HIV-infected men with lipodystrophy. Intervention: Rosiglitazone, 8 mg/d, or metformin, 2 g/d. Measurements: Insulin sensitivity estimated by the oral glucose tolerance test, subcutaneous and visceral abdominal fat measured by single-slice computed tomography, endothelial function measured by flow-mediated vasodilation, and fasting plasma measurements. Two patients in the metformin group withdrew from the study. Complete case analysis was performed. Results: Compared with metformin, rosiglitazone increased subcutaneous abdominal fat (between-treatment change from baseline, 27 cm2 [95% CI, 7 cm2 to 46 cm2]) and visceral abdominal fat (between-treatment change from baseline, 24 cm2 [CI, 6 cm2 to 51 cm2]). The area under the curve for insulin after the oral glucose tolerance test decreased similarly with both agents, but only rosiglitazone increased adiponectin levels. Metformin showed greater benefits on fasting lipid profile than rosiglitazone. Flow-mediated vasodilation statistically significantly increased with metformin (mean change, 1.5% [CI, 0.4% to 3.3%]) and not with rosiglitazone (mean change, 0.7% [CI, −1.1% to 2.7%]). The metformin versus rosiglitazone increases did not statistically differ. Rosiglitazone and metformin did not change C-reactive protein levels. Limitations: This small trial was not blinded or placebo-controlled and did not measure clinical outcomes. Conclusions: The findings emphasize the importance of individualized care in HIV-infected patients. Although rosiglitazone may partly correct lipoatrophy, metformin improves visceral fat accumulation, fasting lipid profile, and endothelial function.

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Crossref · 10.7326/0003-4819-143-5-200509060-00009

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Metadata

Authors
van Wijk, J. P. H., de Koning, E. J. P., Cabezas, M. C., op't Roodt, J., Joven, J., Rabelink, T. J., & Hoepelman, A. I.
Affiliations
  • From University Medical Center, Utrecht, the Netherlands; Leiden University Medical Center, Leiden, the Netherlands; St. Franciscus Gasthuis, Rotterdam, the Netherlands; and Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Reus, Spain.
  • Leiden University Medical Center (NL)
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2005-09-06
Volume
143
Issue
5
Pages
337-346
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-143-5-200509060-00009
OpenAlex
W1490891702
Cited by
3
References
52
FWCI
0.74
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
Annals of Internal Medicine (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
HIV lipodystrophy, rosiglitazone, metformin, peroxisome proliferator-activated receptor gamma agonists, insulin sensitivity, visceral fat, subcutaneous abdominal fat, adiponectin, endothelial function, flow-mediated dilation, fasting lipid profile, C-reactive protein, antiretroviral therapy adverse effects, lipoatrophy

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