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Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy
Abstract
OBJECTIVE: To determine liver fat content in patients with highly active antiretroviral therapy (HAART)-associated lipodystrophy. BACKGROUND: Lipodystrophy in several animal models is associated with fat accumulation in insulin-sensitive tissues, such as the liver. This causes hyperinsulinaemia, dyslipidaemia and other features of insulin resistance. DESIGN: A cross-sectional study. SUBJECTS AND METHODS: Three age- and weight-matched groups were compared: 25 HIV-positive men with HAART-associated lipodystrophy (HAART+LD+), nine HIV-positive men receiving HAART, but without lipodystrophy (HAART+LD-), and 35 HIV-negative healthy men (HIV-). Liver fat content was measured using proton spectroscopy. Intra-abdominal and subcutaneous fat were determined using magnetic resonance imaging. RESULTS: Liver fat content was significantly higher in the HAART+LD+ (8 +/- 10%) than the HIV- (5 +/- 7%; P < 0.05) or the HAART+LD- (3 +/- 5%; P < 0.01) group. Liver fat content correlated with serum fasting insulin in the HAART+LD+ (r = 0.47; P < 0.05) and HIV- groups (r = 0.65; < 0.001), but not with the amount of intra-abdominal fat. Within the HAART+LD+ group, serum insulin did not correlate with the amount of intra-abdominal fat. The HAART+LD+ group had a lower serum leptin concentration when compared to the two other groups. Features of insulin resistance, including hepatic fat accumulation, were not found in HAART+LD-group. CONCLUSIONS: The severity of the insulin resistance syndrome in patients with HAART-associated lipodystrophy is related to the extent of fat accumulation in the liver rather than in the intra-abdominal region. Fat accumulation in the liver may therefore play a causative role in the development of insulin resistance in these patients.
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“The reproducibility of repeated measurements of liver fat in nondiabetic subjects studied on 2 separate occasions by the same reader in our laboratory is 11%.47”
From Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. (2008) · cites this paper as [47]
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Dietary fat content modifies liver fat in overweight nondiabetic subjects
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Metadata
- Authors
- Sutinen, J., Häkkinen, A.-M., Westerbacka, J., Seppälä-Lindroos, A., Vehkavaara, S., Halavaara, J., Järvinen, A., Ristola, M., & Yki-Järvinen, H.
- Affiliations
- Helsinki University Hospital (FI)
- Corresponding author
- Sutinen, Jussi
- Venue
- AIDS
- Published
- 2002-11
- Volume
- 16
- Issue
- 16
- Pages
- 2183-2193
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2319607702
- Cited by
- 184
- References
- 58
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 6
- FWCI
- 21.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- HIV infection, antiretroviral therapy, lipodystrophy, hepatic lipid accumulation, insulin resistance, hyperinsulinemia, leptin, intra-abdominal fat, subcutaneous adipose tissue, 1H NMR, dyslipidemia
- MeSH terms
- Adipose Tissue, Adult, Cross-Sectional Studies, Humans, Liver, Male, Protons, Spectrum Analysis, HIV Infections, Antiretroviral Therapy, Highly Active, HIV-Associated Lipodystrophy Syndrome
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