Cited by 173Atrial Fibrillation Management and OutcomesAcute Ischemic Stroke ManagementVenous Thromboembolism Diagnosis and Management

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Adjusted-Dose Warfarin versus Aspirin for Preventing Stroke in Patients with Atrial Fibrillation

Hart, Robert G., Pearce, Lesly A., Aguilar, Maria I.·2007·Annals of Internal Medicine

DOI 10.7326/0003-4819-147-8-200710160-00018

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Letters16 October 2007Adjusted-Dose Warfarin versus Aspirin for Preventing Stroke in Patients with Atrial FibrillationRobert G. Hart, MD, Lesly A. Pearce, MS, and Maria I. Aguilar, MDRobert G. Hart, MDFrom the University of Texas Health Science Center, San Antonio, TX 78229-3900; Minot, ND 58703; and Mayo Clinic Scottsdale, Phoenix, AZ 85054., Lesly A. Pearce, MSFrom the University of Texas Health Science Center, San Antonio, TX 78229-3900; Minot, ND 58703; and Mayo Clinic Scottsdale, Phoenix, AZ 85054., and Maria I. Aguilar, MDFrom the University of Texas Health Science Center, San Antonio, TX 78229-3900; Minot, ND 58703; and Mayo Clinic Scottsdale, Phoenix, AZ 85054.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-8-200710160-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recently published, randomized Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) Study compared adjusted-dose warfarin (target international normalized ratio, 2.0 to 3.0) with aspirin (75 mg/d) in 973 patients with atrial fibrillation who were 75 years of age or older (mean age, 81.5 years) and were managed by general practitioners in the United Kingdom (1). The study's important results indicate that the relative efficacy and safety of warfarin for stroke prevention can be extended to very elderly patients who are managed by nonspecialists. Because the BAFTA Study seems likely to be the last large trial comparing ...References1. Mant J, Hobbs FD, Fletcher K, Roalfe A, Fitzmaurice D, Lip GY, et al. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet. 2007;370:493-503. [PMID: 17693178] CrossrefMedlineGoogle Scholar2. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146:857-67. [PMID: 17577005] LinkGoogle Scholar3. Petersen P, Boysen G, Godtfredsen J, Andersen ED, Andersen B. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study. Lancet. 1989;1:175-9. [PMID: 2563096] CrossrefMedlineGoogle Scholar4. Petersen P, Boysen G. 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Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet. 2006;367:1903-12. [PMID: 16765759] CrossrefMedlineGoogle Scholar12. NASPEAF Investigators. Comparative effects of antiplatelet, anticoagulant, or combined therapy in patients with valvular and nonvalvular atrial fibrillation: a randomized multicenter study. J Am Coll Cardiol. 2004;44:1557-66. [PMID: 15489085] CrossrefMedlineGoogle Scholar13. Vemmos KN, Tsivgoulis G, Spengos K, Manios E, Xin

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Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
Hart, R. G., Pearce, L. A., & Aguilar, M. I. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-12-200706190-00007 · Cited by 4,793
Self-citation
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial
(2006) · The Lancet · doi:10.1016/s0140-6736(06)68845-4 · Cited by 1,952
Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke
EAFT (European Atrial Fibrillation Trial) Study Group (1993) · The Lancet · doi:10.1016/0140-6736(93)92358-z · Cited by 1,877
PLACEBO-CONTROLLED, RANDOMISED TRIAL OF WARFARIN AND ASPIRIN FOR PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN CHRONIC ATRIAL FIBRILLATION
Petersen, P., GODTFREDSEN, J., Boysen, G., Andersen, E. D., & Andersen, B. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91200-2 · Cited by 1,814
Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial
Mant, J., Hobbs, F. R., Fletcher, K., Roalfe, A., Fitzmaurice, D., Lip, G. Y., & Murray, E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61233-1 · Cited by 1,556
Fixed Minidose Warfarin and Aspirin Alone and in Combination vs Adjusted-Dose Warfarin for Stroke Prevention in Atrial Fibrillation
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A randomised controlled trial of warfarin versus aspirin for stroke prevention in octogenarians with atrial fibrillation (WASPO)
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Morocutti, C., Amabile, G. A., Fattapposta, F., Nicolosi, A., Matteoli, S., Trappolini, M., Cataldo, G., Milanesi, G., Lavezzari, M., Pamparana, F., et al. (1997) · Stroke · doi:10.1161/01.str.28.5.1015 · Cited by 198

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Petersen P, 1990, N Engl J Med, 323, 482
Antithrombotic Therapy in Atrial Fibrillation Study Group, 2006, Zhonghua Xin Xue Guan Bing Za Zhi, 34, 295
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Authors: Hart, R. G., Pearce, L. A., & Aguilar, M. I.
Affiliations: Mayo Clinic (US)
ORCID: Hart, Robert G.
Pearce, Lesly A.
Aguilar, Maria I.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 2007-10-16
Volume: 147
Issue: 8
Pages: 590-592
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-147-8-200710160-00018
OpenAlex: W2081134280
Cited by: 173
References: 13
Citations by year: 2025: 3 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 18 · 2017: 15 · 2016: 13 · 2015: 16 · 2014: 14 · 2013: 13 · 2012: 11
FWCI: 3.98
Type: journal article
Language: en
Open access: closed
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
Keywords: atrial fibrillation, stroke prevention, aspirin, anticoagulation, elderly patients, general practitioners, international normalized ratio, non-specialist management, antithrombotic therapy, bleeding risk, cost-effectiveness, quality of life
MeSH terms: Aged, Aged, 80 and over, Anticoagulants, Aspirin, Atrial Fibrillation, Fibrinolytic Agents, Humans, Warfarin, Stroke

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Adjusted-Dose Warfarin versus Aspirin for Preventing Stroke in Patients with Atrial Fibrillation

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