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Adjusted-Dose Warfarin versus Aspirin for Preventing Stroke in Patients with Atrial Fibrillation
Abstract
Letters16 October 2007Adjusted-Dose Warfarin versus Aspirin for Preventing Stroke in Patients with Atrial FibrillationRobert G. Hart, MD, Lesly A. Pearce, MS, and Maria I. Aguilar, MDRobert G. Hart, MDFrom the University of Texas Health Science Center, San Antonio, TX 78229-3900; Minot, ND 58703; and Mayo Clinic Scottsdale, Phoenix, AZ 85054., Lesly A. Pearce, MSFrom the University of Texas Health Science Center, San Antonio, TX 78229-3900; Minot, ND 58703; and Mayo Clinic Scottsdale, Phoenix, AZ 85054., and Maria I. Aguilar, MDFrom the University of Texas Health Science Center, San Antonio, TX 78229-3900; Minot, ND 58703; and Mayo Clinic Scottsdale, Phoenix, AZ 85054.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-8-200710160-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recently published, randomized Birmingham Atrial Fibrillation Treatment of the Aged (BAFTA) Study compared adjusted-dose warfarin (target international normalized ratio, 2.0 to 3.0) with aspirin (75 mg/d) in 973 patients with atrial fibrillation who were 75 years of age or older (mean age, 81.5 years) and were managed by general practitioners in the United Kingdom (1). The study's important results indicate that the relative efficacy and safety of warfarin for stroke prevention can be extended to very elderly patients who are managed by nonspecialists. Because the BAFTA Study seems likely to be the last large trial comparing ...References1. Mant J, Hobbs FD, Fletcher K, Roalfe A, Fitzmaurice D, Lip GY, et al. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet. 2007;370:493-503. [PMID: 17693178] CrossrefMedlineGoogle Scholar2. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146:857-67. [PMID: 17577005] LinkGoogle Scholar3. Petersen P, Boysen G, Godtfredsen J, Andersen ED, Andersen B. Placebo-controlled, randomised trial of warfarin and aspirin for prevention of thromboembolic complications in chronic atrial fibrillation. The Copenhagen AFASAK study. Lancet. 1989;1:175-9. [PMID: 2563096] CrossrefMedlineGoogle Scholar4. Petersen P, Boysen G. 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“It is superior to no treatment or aspirin in patients with different profiles for stroke risk.”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [353]
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Metadata
- Authors
- Hart, R. G., Pearce, L. A., & Aguilar, M. I.
- Affiliations
- Mayo Clinic (US)
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2007-10-16
- Volume
- 147
- Issue
- 8
- Pages
- 590-592
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2081134280
- Cited by
- 173
- References
- 13
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 18 · 2017: 15 · 2016: 13 · 2015: 16 · 2014: 14 · 2013: 13 · 2012: 11
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- atrial fibrillation, stroke prevention, aspirin, anticoagulation, elderly patients, general practitioners, international normalized ratio, non-specialist management, antithrombotic therapy, bleeding risk, cost-effectiveness, quality of life
- MeSH terms
- Aged, Aged, 80 and over, Anticoagulants, Aspirin, Atrial Fibrillation, Fibrinolytic Agents, Humans, Warfarin, Stroke
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