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Cited by 115Reproductive tract infections researchAntibiotic Resistance in BacteriaBacterial Infections and Vaccines

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Neisseria gonorrhoeae Antimicrobial Resistance Among Men Who Have Sex With Men and Men Who Have Sex Exclusively With Women: The Gonococcal Isolate Surveillance Project, 2005–2010

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Kirkcaldy, Robert D., Zaidi, Akbar, Hook, Edward W., Holmes, King K., Soge, Olusegun, del Rio, Carlos, Hall, Geraldine, Papp, John, Bolan, Gail, Weinstock, Hillard S.·2013·Annals of Internal Medicine
DOI 10.7326/0003-4819-158-5-201303050-00004PMC PMC6697257
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Abstract

BACKGROUND: Gonorrhea treatment has been complicated by antimicrobial resistance in Neisseria gonorrhoeae. Gonococcal fluoroquinolone resistance emerged more rapidly among men who have sex with men (MSM) than men who have sex exclusively with women (MSW). OBJECTIVE: To determine whether N. gonorrhoeae urethral isolates from MSM were more likely than isolates from MSW to exhibit resistance to or elevated minimum inhibitory concentrations (MICs) of antimicrobials used to treat gonorrhea. DESIGN: 6 years of surveillance data from the Gonococcal Isolate Surveillance Project. SETTING: Publicly funded sexually transmitted disease clinics in 30 U.S. cities. PATIENTS: Men with a total of 34 600 episodes of symptomatic urethral gonorrhea. MEASUREMENTS: Percentage of isolates exhibiting resistance or elevated MICs and adjusted odds ratios for resistance or elevated MICs among isolates from MSM compared with isolates from MSW. RESULTS: In all U.S. regions except the West, isolates from MSM were significantly more likely to exhibit elevated MICs of ceftriaxone and azithromycin than isolates from MSW (P < 0.050). Isolates from MSM had a high prevalence of resistance to ciprofloxacin, penicillin, and tetracycline and were significantly more likely to exhibit antimicrobial resistance than isolates from MSW (P < 0.001). LIMITATIONS: Sentinel surveillance may not be representative of all patients with gonorrhea. HIV status, travel history, and antimicrobial use data were missing for some patients. CONCLUSION: Men who have sex with men are vulnerable to the emerging threat of antimicrobial-resistant N. gonorrhoeae. Because antimicrobial susceptibility testing is not routinely done in clinical practice, clinicians should monitor for treatment failures among MSM diagnosed with gonorrhea. Strengthened prevention strategies for MSM and new antimicrobial treatment options are needed.

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Research works printed but not linked: 8

  1. Centers for Disease Control and Prevention (CDC), 2002, MMWR Morb Mortal Wkly Rep, 51, 1041
  2. Centers for Disease Control and Prevention (CDC), 2004, MMWR Morb Mortal Wkly Rep, 53, 335
  3. Centers for Disease Control and Prevention (CDC), 2007, MMWR Morb Mortal Wkly Rep, 56, 332
  4. Centers for Disease Control and Prevention (CDC), 2012, MMWR Morb Mortal Wkly Rep, 61, 590
  5. Unemo M, 2010, Euro Surveill, 15
  6. Centers for Disease Control and Prevention (CDC), 2011, MMWR Morb Mortal Wkly Rep, 60, 579
  7. Fagan D, 1985, Genitourin Med, 61, 363
  8. Workowski KA, 2010, MMWR Recomm Rep, 59, 1

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Metadata

Authors
Kirkcaldy, R. D., Zaidi, A., Hook, E. W., Holmes, K. K., Soge, O., del Rio, C., Hall, G., Papp, J., Bolan, G., & Weinstock, H. S.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • From the Centers for Disease Control and Prevention and Emory University, Atlanta, Georgia; University of Alabama and Jefferson County Department of Health, Birmingham, Alabama; University of Washington, Seattle, Washington; and Cleveland Clinic, Cleveland, Ohio.
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2013-03-05
Volume
158
Issue
5_Part_1
Pages
321-328
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-158-5-201303050-00004
PMC
PMC6697257
OpenAlex
W2094084565
Cited by
115
References
38
Citations by year
2026: 6 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 14 · 2017: 14 · 2016: 15 · 2015: 9 · 2014: 12 · 2013: 10
FWCI
14.07
Type
journal article
Language
en
Open access
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (CC999999)
  • Centers for Disease Control and Prevention (H25PS001412)
  • National Institute of Allergy and Infectious Diseases (P30AI050409)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Keywords
Neisseria gonorrhoeae, gonorrhea, antimicrobial resistance, men who have sex with men, fluoroquinolone resistance, ceftriaxone resistance, azithromycin resistance, ciprofloxacin resistance, penicillin resistance, tetracycline resistance, minimum inhibitory concentration, sexually transmitted infections
MeSH terms
Adult, Anti-Bacterial Agents, Ceftriaxone, Ciprofloxacin, Doxycycline, Female, Gonorrhea, Homosexuality, Humans, Male, Microbial Sensitivity Tests, Neisseria gonorrhoeae, Penicillins, Sensitivity and Specificity, Tetracycline, Logistic Models, Azithromycin, Sentinel Surveillance, Heterosexuality, Drug Resistance, Bacterial

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