The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Neisseria gonorrhoeae Antimicrobial Resistance Among Men Who Have Sex With Men and Men Who Have Sex Exclusively With Women: The Gonococcal Isolate Surveillance Project, 2005–2010
Open accessAbstract
BACKGROUND: Gonorrhea treatment has been complicated by antimicrobial resistance in Neisseria gonorrhoeae. Gonococcal fluoroquinolone resistance emerged more rapidly among men who have sex with men (MSM) than men who have sex exclusively with women (MSW). OBJECTIVE: To determine whether N. gonorrhoeae urethral isolates from MSM were more likely than isolates from MSW to exhibit resistance to or elevated minimum inhibitory concentrations (MICs) of antimicrobials used to treat gonorrhea. DESIGN: 6 years of surveillance data from the Gonococcal Isolate Surveillance Project. SETTING: Publicly funded sexually transmitted disease clinics in 30 U.S. cities. PATIENTS: Men with a total of 34 600 episodes of symptomatic urethral gonorrhea. MEASUREMENTS: Percentage of isolates exhibiting resistance or elevated MICs and adjusted odds ratios for resistance or elevated MICs among isolates from MSM compared with isolates from MSW. RESULTS: In all U.S. regions except the West, isolates from MSM were significantly more likely to exhibit elevated MICs of ceftriaxone and azithromycin than isolates from MSW (P < 0.050). Isolates from MSM had a high prevalence of resistance to ciprofloxacin, penicillin, and tetracycline and were significantly more likely to exhibit antimicrobial resistance than isolates from MSW (P < 0.001). LIMITATIONS: Sentinel surveillance may not be representative of all patients with gonorrhea. HIV status, travel history, and antimicrobial use data were missing for some patients. CONCLUSION: Men who have sex with men are vulnerable to the emerging threat of antimicrobial-resistant N. gonorrhoeae. Because antimicrobial susceptibility testing is not routinely done in clinical practice, clinicians should monitor for treatment failures among MSM diagnosed with gonorrhea. Strengthened prevention strategies for MSM and new antimicrobial treatment options are needed.
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“Similarly, gonorrhea incidence has increased among MSM and might be more likely to display antimicrobial resistance compared with other groups (188,189).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [189]
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Cites
Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines
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Self-citation
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Sexually Transmitted Infections Treatment Guidelines, 2021
Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr7004a1 · Cited by 3,018
Self-citationKirkcaldy, R. D., Harvey, A., Papp, J. R., del Rio, C., Soge, O. O., Holmes, K. K., Hook, E. W., Kubin, G., Riedel, S., Zenilman, J., et al. (2016) · MMWR Surveillance Summaries · doi:10.15585/mmwr.ss6507a1 · Cited by 249
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Metadata
- Authors
- Kirkcaldy, R. D., Zaidi, A., Hook, E. W., Holmes, K. K., Soge, O., del Rio, C., Hall, G., Papp, J., Bolan, G., & Weinstock, H. S.
- Affiliations
- Centers for Disease Control and Prevention (US)
- From the Centers for Disease Control and Prevention and Emory University, Atlanta, Georgia; University of Alabama and Jefferson County Department of Health, Birmingham, Alabama; University of Washington, Seattle, Washington; and Cleveland Clinic, Cleveland, Ohio.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2013-03-05
- Volume
- 158
- Issue
- 5_Part_1
- Pages
- 321-328
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- PMC
- PMC6697257
- OpenAlex
- W2094084565
- Cited by
- 115
- References
- 38
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 14 · 2017: 14 · 2016: 15 · 2015: 9 · 2014: 12 · 2013: 10
- FWCI
- 14.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (CC999999)
- Centers for Disease Control and Prevention (H25PS001412)
- National Institute of Allergy and Infectious Diseases (P30AI050409)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- Neisseria gonorrhoeae, gonorrhea, antimicrobial resistance, men who have sex with men, fluoroquinolone resistance, ceftriaxone resistance, azithromycin resistance, ciprofloxacin resistance, penicillin resistance, tetracycline resistance, minimum inhibitory concentration, sexually transmitted infections
- MeSH terms
- Adult, Anti-Bacterial Agents, Ceftriaxone, Ciprofloxacin, Doxycycline, Female, Gonorrhea, Homosexuality, Humans, Male, Microbial Sensitivity Tests, Neisseria gonorrhoeae, Penicillins, Sensitivity and Specificity, Tetracycline, Logistic Models, Azithromycin, Sentinel Surveillance, Heterosexuality, Drug Resistance, Bacterial
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