The DOI matches its Crossref record; 90 of the 91 references it cites were found in a registry or an index.
Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force
Abstract
BACKGROUND: Vitamin and mineral supplements are commonly used to prevent chronic diseases. PURPOSE: To systematically review evidence for the benefit and harms of vitamin and mineral supplements in community-dwelling, nutrient-sufficient adults for the primary prevention of cardiovascular disease (CVD) and cancer. DATA SOURCES: MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Database of Abstracts of Reviews of Effects were searched from January 2005 to 29 January 2013, with manual searches of reference lists and gray literature. STUDY SELECTION: Two investigators independently selected and reviewed fair- and good-quality trials for benefit and fair- and good-quality trials and observational studies for harms. DATA EXTRACTION: Dual quality assessments and data abstraction. DATA SYNTHESIS: Two large trials (n = 27 658) reported lower cancer incidence in men taking a multivitamin for more than 10 years (pooled unadjusted relative risk, 0.93 [95% CI, 0.87 to 0.99]). The study that included women showed no effect in that group. High-quality studies (k = 24; n = 324 653) of single and paired nutrients (such as vitamins A, C, or D; folic acid; selenium; or calcium) were scant and heterogeneous and showed no clear evidence of benefit or harm. Neither vitamin E nor β-carotene prevented CVD or cancer, and β-carotene increased lung cancer risk in smokers. LIMITATIONS: The analysis included only primary prevention studies in adults without known nutritional deficiencies. Studies were conducted in older individuals and included various supplements and doses under the set upper tolerable limits. Duration of most studies was less than 10 years. CONCLUSION: Limited evidence supports any benefit from vitamin and mineral supplementation for the prevention of cancer or CVD. Two trials found a small, borderline-significant benefit from multivitamin supplements on cancer in men only and no effect on CVD. PRIMARY FUNDING SOURCE: Agency for Healthcare Research and Quality.
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“It is important to point out that a causal association between a reduced risk of illness and antioxidant consumption is still missing and more placebo-controlled interventions are necessary to justify antioxidant supplementation15–19.”
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“Nonetheless, the impact of vitamin E supplementation on cardiovascular mortality or prostate cancer is still not settled and clinical intervention studies have shown no bene fi t.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [368]
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Cites
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2021) · doi:10.1002/9781119558378 · Cited by 9,799
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638
Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin
Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,988
Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., LaMotte, F., Gaziano, J. M., Ridker, P. M., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341801 · Cited by 2,397
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers
Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,164
Klein, E. A., Thompson, I. M., Tangen, C. M., Crowley, J. J., Lucia, M. S., Goodman, P. J., Minasian, L. M., Ford, L. G., Parnes, H. L., Gaziano, J. M., et al. (2011) · JAMA · doi:10.1001/jama.2011.1437 · Cited by 1,787
Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
Lappe, J. M., Travers‐Gustafson, D., Davies, K. M., Recker, R. R., & Heaney, R. P. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1586 · Cited by 1,445
Trivedi, D. P., Doll, R., & Khaw, K. (2003) · BMJ · doi:10.1136/bmj.326.7387.469 · Cited by 1,273
Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137
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1 of the 91 references couldn’t be matched to a known paper.
Research works printed but not linked: 12
- Gahche J, 2011, NCHS Data Brief, 1
- Huang HY, 2006, Evid Rep Technol Assess (Full Rep), 1
- 10.1001/jama.1996.03540240035027 · DOI
- Moon TE, 1997, Cancer Epidemiol Biomarkers Prev, 6, 949
- Levine N, 1997, Cancer Epidemiol Biomarkers Prev, 6, 957
- Hercberg S, 1998, Int J Vitam Nutr Res, 68, 3
- Bjelakovic G, 2008, Cochrane Database Syst Rev, CD004183
- Bjelakovic G, 2008, Cochrane Database Syst Rev, CD007176
- Rees K, 2013, Cochrane Database Syst Rev, 1, CD009671
- Alkhenizan A, 2007, Ann Saudi Med, 27, 409
- Ford JA, 2012, Circulation, 126, A18397
- Duffield-Lillico AJ, 2002, Cancer Epidemiol Biomarkers Prev, 11, 630
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Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects
Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L., & Carmeliet, G. (2015) · Physiological Reviews · doi:10.1152/physrev.00014.2015 · Cited by 2,105
Global Epidemiology of Lung Cancer
Barta, J. A., Powell, C. A., & Wisnivesky, J. P. (2019) · Annals of Global Health · doi:10.5334/aogh.2419 · Cited by 1,654
Oxidative stress inhibits distant metastasis by human melanoma cells
Piskounova, E., Agathocleous, M., Murphy, M. M., Hu, Z., Huddlestun, S. E., Zhao, Z., Leitch, A. M., Johnson, T. M., DeBerardinis, R. J., & Morrison, S. J. (2015) · Nature · doi:10.1038/nature15726 · Cited by 1,269
Lichtenstein, A. H., Appel, L. J., Vadiveloo, M., Hu, F. B., Kris-Etherton, P. M., Rebholz, C. M., Sacks, F. M., Thorndike, A. N., Van Horn, L., Wylie-Rosett, J., et al. (2021) · Circulation · doi:10.1161/cir.0000000000001031 · Cited by 1,065
Metadata
- Authors
- Fortmann, S. P., Burda, B. U., Senger, C. A., Lin, J. S., & Whitlock, E. P.
- Affiliations
- Kaiser Permanente Center for Health Research (US)
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2013-12
- Volume
- 159
- Issue
- 12
- Pages
- 824-834
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2168613688
- Cited by
- 442
- References
- 91
- Citations by year
- 2026: 14 · 2025: 14 · 2024: 31 · 2023: 29 · 2022: 30 · 2021: 46 · 2020: 29 · 2019: 28 · 2018: 43 · 2017: 41 · 2016: 36 · 2015: 41 · 2014: 58 · 2013: 2
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (HHS-290-2007-10057-I)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- vitamin supplements, mineral supplements, multivitamins, cardiovascular disease prevention, cancer prevention, primary prevention, vitamin E, beta-carotene, selenium, calcium, folic acid, vitamin A, vitamin C, vitamin D
- MeSH terms
- Cardiovascular Diseases, Humans, Minerals, Neoplasms, Primary Prevention, Vitamins, Incidence, Dietary Supplements
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