Cited by 442Nutrition and Health StudiesAntioxidant Activity and Oxidative StressNutritional Studies and Diet

The DOI matches its Crossref record; 90 of the 91 references it cites were found in a registry or an index.

Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force

Fortmann, Stephen P., Burda, Brittany U., Senger, Caitlyn A., Lin, Jennifer S., Whitlock, Evelyn P.·2013·Annals of Internal Medicine

DOI 10.7326/0003-4819-159-12-201312170-00729

Open this paper in CoChat — free account

Abstract

BACKGROUND: Vitamin and mineral supplements are commonly used to prevent chronic diseases. PURPOSE: To systematically review evidence for the benefit and harms of vitamin and mineral supplements in community-dwelling, nutrient-sufficient adults for the primary prevention of cardiovascular disease (CVD) and cancer. DATA SOURCES: MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Database of Abstracts of Reviews of Effects were searched from January 2005 to 29 January 2013, with manual searches of reference lists and gray literature. STUDY SELECTION: Two investigators independently selected and reviewed fair- and good-quality trials for benefit and fair- and good-quality trials and observational studies for harms. DATA EXTRACTION: Dual quality assessments and data abstraction. DATA SYNTHESIS: Two large trials (n = 27 658) reported lower cancer incidence in men taking a multivitamin for more than 10 years (pooled unadjusted relative risk, 0.93 [95% CI, 0.87 to 0.99]). The study that included women showed no effect in that group. High-quality studies (k = 24; n = 324 653) of single and paired nutrients (such as vitamins A, C, or D; folic acid; selenium; or calcium) were scant and heterogeneous and showed no clear evidence of benefit or harm. Neither vitamin E nor β-carotene prevented CVD or cancer, and β-carotene increased lung cancer risk in smokers. LIMITATIONS: The analysis included only primary prevention studies in adults without known nutritional deficiencies. Studies were conducted in older individuals and included various supplements and doses under the set upper tolerable limits. Duration of most studies was less than 10 years. CONCLUSION: Limited evidence supports any benefit from vitamin and mineral supplementation for the prevention of cancer or CVD. Two trials found a small, borderline-significant benefit from multivitamin supplements on cancer in men only and no effect on CVD. PRIMARY FUNDING SOURCE: Agency for Healthcare Research and Quality.

Integrity signals

Registry

Crossref · 10.7326/0003-4819-159-12-201312170-00729

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Introduction to Meta‐Analysis
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2021) · doi:10.1002/9781119558378 · Cited by 9,799
The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638
Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin
Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,988
Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease
Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., LaMotte, F., Gaziano, J. M., Ridker, P. M., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341801 · Cited by 2,397
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers
Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,164
Vitamin E and the Risk of Prostate Cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Klein, E. A., Thompson, I. M., Tangen, C. M., Crowley, J. J., Lucia, M. S., Goodman, P. J., Minasian, L. M., Ford, L. G., Parnes, H. L., Gaziano, J. M., et al. (2011) · JAMA · doi:10.1001/jama.2011.1437 · Cited by 1,787
Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial
Lappe, J. M., Travers‐Gustafson, D., Davies, K. M., Recker, R. R., & Heaney, R. P. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1586 · Cited by 1,445
Effect of four monthly oral vitamin D 3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial
Trivedi, D. P., Doll, R., & Khaw, K. (2003) · BMJ · doi:10.1136/bmj.326.7387.469 · Cited by 1,273
Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women’s Health Study: A Randomized Controlled Trial
Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137

Show all 91 references

Research works printed but not linked: 12

Gahche J, 2011, NCHS Data Brief, 1
Huang HY, 2006, Evid Rep Technol Assess (Full Rep), 1
10.1001/jama.1996.03540240035027 · DOI
Moon TE, 1997, Cancer Epidemiol Biomarkers Prev, 6, 949
Levine N, 1997, Cancer Epidemiol Biomarkers Prev, 6, 957
Hercberg S, 1998, Int J Vitam Nutr Res, 68, 3
Bjelakovic G, 2008, Cochrane Database Syst Rev, CD004183
Bjelakovic G, 2008, Cochrane Database Syst Rev, CD007176
Rees K, 2013, Cochrane Database Syst Rev, 1, CD009671
Alkhenizan A, 2007, Ann Saudi Med, 27, 409
Ford JA, 2012, Circulation, 126, A18397
Duffield-Lillico AJ, 2002, Cancer Epidemiol Biomarkers Prev, 11, 630

Sorted by citations

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD).
Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects
Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L., & Carmeliet, G. (2015) · Physiological Reviews · doi:10.1152/physrev.00014.2015 · Cited by 2,105
Global Epidemiology of Lung Cancer
Barta, J. A., Powell, C. A., & Wisnivesky, J. P. (2019) · Annals of Global Health · doi:10.5334/aogh.2419 · Cited by 1,654
Oxidative stress inhibits distant metastasis by human melanoma cells
Piskounova, E., Agathocleous, M., Murphy, M. M., Hu, Z., Huddlestun, S. E., Zhao, Z., Leitch, A. M., Johnson, T. M., DeBerardinis, R. J., & Morrison, S. J. (2015) · Nature · doi:10.1038/nature15726 · Cited by 1,269
2021 Dietary guidance to improve cardiovascular health: a scientific statement from the American Heart Association
Lichtenstein, A. H., Appel, L. J., Vadiveloo, M., Hu, F. B., Kris-Etherton, P. M., Rebholz, C. M., Sacks, F. M., Thorndike, A. N., Van Horn, L., Wylie-Rosett, J., et al. (2021) · Circulation · doi:10.1161/cir.0000000000001031 · Cited by 1,065
Role of ROS and Nutritional Antioxidants in Human Diseases
Liu, Z., Ren, Z., Zhang, J., Chuang, C.-C., Kandaswamy, E., Zhou, T., & Zuo, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00477 · Cited by 860
Vitamin C: The known and the unknown and Goldilocks
Padayatty, S., & Levine, M. (2016) · Oral Diseases · doi:10.1111/odi.12446 · Cited by 753
Selenium for preventing cancer
Vinceti, M., Filippini, T., Del Giovane, C., Dennert, G., Zwahlen, M., Brinkman, M., Zeegers, M. P., Horneber, M., D'Amico, R., & Crespi, C. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub4 · Cited by 649
ROS in Cancer: The Burning Question
Chio, I. I. C., & Tuveson, D. A. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.004 · Cited by 532
Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies
Aleksandrova, K., Koelman, L., & Rodrigues, C. E. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101869 · Cited by 555
EASL-EASD-EASO Clinical Practice Guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 545
A synopsis on aging—Theories, mechanisms and future prospects
da Costa, J. P., Vitorino, R. M. P., Silva, G. M., Vogel, C., Duarte, A. C., & Rocha‐Santos, T. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.005 · Cited by 505
Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits
Ristow, M. (2014) · Nature Medicine · doi:10.1038/nm.3624 · Cited by 417
The 2015 Dutch food-based dietary guidelines
Kromhout, D., Spaaij, C. J. K., de Goede, J., & Weggemans, R. M. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.52 · Cited by 416
Fast food fever: reviewing the impacts of the Western diet on immunity
Myles, I. A. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-61 · Cited by 409
Targeting cancer-promoting inflammation — have anti-inflammatory therapies come of age?
Hou, J., Karin, M., & Sun, B. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-00459-9 · Cited by 387
Adverse Effects of Nutraceuticals and Dietary Supplements
Ronis, M. J. J., Pedersen, K. B., & Watt, J. D. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052844 · Cited by 393
Cardiovascular Disease Prevention by Diet Modification
Yu, E., Malik, V., & Hu, F. B. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.02.085 · Cited by 378
Potential of plant polyphenols to combat oxidative stress and inflammatory processes in farm animals
Geßner, D. K., Ringseis, R., & Eder, K. (2016) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.12579 · Cited by 370
Health Benefits of Micronutrients (Vitamins and Minerals) and their Associated Deficiency Diseases: A Systematic Review
Awuchi, C. G., Somtochukwu, I. V., Amagwula, I. O., & Echeta, C. K. (2020) · International Journal of Food Sciences · doi:10.47604/ijf.1024 · Cited by 339
ROS signaling and ER stress in cardiovascular disease
Ochoa, C. D., Wu, R.-F., & Terada, L. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.03.002 · Cited by 286
Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation
Collins, E. J., Bowyer, C. J., Tsouza, A., & Chopra, M. (2022) · Biology · doi:10.3390/biology11020239 · Cited by 360
Association Among Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults
Chen, F., Du, M., Blumberg, J. B., Chui, K. K. H., Ruan, M., Rogers, G. T., Shan, Z., Zeng, L., & Zhang, F. F. (2019) · Annals of Internal Medicine · doi:10.7326/m18-2478 · Cited by 293
Diet, nutrition, and cancer: past, present and future
Mayne, S. T., Playdon, M. C., & Rock, C. L. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.24 · Cited by 264
Aspirin for the Primary Prevention of Cardiovascular Events: A Systematic Evidence Review for the U.S. Preventive Services Task Force
Guirguis‐Blake, J., Evans, C. V., Senger, C. A., O’Connor, E., & Whitlock, E. P. (2016) · Annals of Internal Medicine · doi:10.7326/m15-2113 · Cited by 264
Supplemental vitamins and minerals for CVD prevention and treatment
Jenkins, D. J. A., Spence, J. D., Giovannucci, E. L., Kim, Y.-I., Josse, R., Vieth, R., Blanco Mejia, S., Viguiliouk, E., Nishi, S., Sahye-Pudaruth, S., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.04.020 · Cited by 251
Dietary supplements and disease prevention — a global overview
Rautiainen, S., Manson, J. E., Lichtenstein, A. H., & Sesso, H. D. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.54 · Cited by 252
Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data
Rejnmark, L., Bislev, L. S., Cashman, K. D., Eiríksdóttir, G., Gaksch, M., Grübler, M. R., Grimnes, G., Gudnason, V. G., Lips, P. T. A. M., Pilz, S., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180512 · Cited by 241
Scientific Opinion on Dietary Reference Values for vitamin A
EFSA Panel on Dietetic Products, N. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4028 · Cited by 247
Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map
Khan, S. U., Khan, M. U., Riaz, H., Valavoor, S., Zhao, D., Vaughan, L., Okunrintemi, V., Riaz, I. B., Khan, M. S., Kaluski, E., et al. (2019) · Annals of Internal Medicine · doi:10.7326/m19-0341 · Cited by 216
Enough Is Enough: Stop Wasting Money on Vitamin and Mineral Supplements
Güallar, E., Stranges, S., Mulrow, C. D., Appel, L. J., & Miller, E. R. (2013) · Annals of Internal Medicine · doi:10.7326/0003-4819-159-12-201312170-00011 · Cited by 221
What can individuals do to reduce personal health risks from air pollution?
Laumbach, R. J., Meng, Q., & Kipen, H. M. (2015) · PubMed · doi:10.3978/j.issn.2072-1439.2014.12.21 · Cited by 229
Vitamin D supplementation for prevention of cancer in adults
Bjelaković, G., Gluud, L. L., Nikolova, D., Whitfield, K., Krstic, G., Wetterslev, J., & Gluud, C. N. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007469.pub2 · Cited by 216
Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort
Hughes, D. J., Fedirko, V., Jenab, M., Schomburg, L., Méplan, C., Freisling, H., Bueno-de-Mesquita, H. B., Hybsier, S., Becker, N., Czuban, M., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29071 · Cited by 218
European Code against Cancer 4th Edition: Diet and cancer
Norat, T., Scoccianti, C., Boutron‐Ruault, M., Anderson, A. S., Berrino, F., Cecchini, M., Espina, C., Key, T. J., Leitzmann, M. F., Powers, H. J., et al. (2015) · Cancer Epidemiology · doi:10.1016/j.canep.2014.12.016 · Cited by 216
Glycemic Variability and Oxidative Stress: A Link between Diabetes and Cardiovascular Disease?
Saisho, Y. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151018381 · Cited by 204
Polypharmacy Management in Older Patients
Hoel, R. W., Connolly, R. M. G., & Takahashi, P. Y. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.06.012 · Cited by 235
Dietary Supplement Use Was Very High among Older Adults in the United States in 2011–2014
Gahche, J. J., Bailey, R. L., Potischman, N. A., & Dwyer, J. T. (2017) · Journal of Nutrition · doi:10.3945/jn.117.255984 · Cited by 195
Too Little, Too Late: Ineffective Regulation of Dietary Supplements in the United States
Starr, R. R. (2015) · American Journal of Public Health · doi:10.2105/ajph.2014.302348 · Cited by 190
Ischemic heart disease in women: A focus on risk factors
Mehta, P. K., Wei, J., & WENGER, N. K. (2014) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.10.005 · Cited by 191
Breast Cancer Subtypes Present a Differential Production of Reactive Oxygen Species (ROS) and Susceptibility to Antioxidant Treatment
Sarmiento-Salinas, F. L., Delgado-Magallón, A., Montes-Alvarado, J. B., Ramírez-Ramírez, D., Flores-Alonso, J. C., Cortés-Hernández, P., Reyes‐Leyva, J., Camacho, I. H., Anaya-Ruı́z, M., Pelayo, R., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00480 · Cited by 180
Mitohormesis in exercise training
Merry, T. L., & Ristow, M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.11.032 · Cited by 176
The role of epigenetic modifications in cardiovascular disease: A systematic review
Muka, T., Koromani, F., Portilla, E. C., O’Connor, A., Bramer, W. M., Troup, J., Chowdhury, R., Dehghan, A., & Franco, O. H. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.03.062 · Cited by 178
Vitamin D and Cancer Risk and Mortality: State of the Science, Gaps, and Challenges
Mondul, A. M., Weinstein, S. J., Layne, T. M., & Albanes, D. (2017) · Epidemiologic Reviews · doi:10.1093/epirev/mxx005 · Cited by 175
The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis
Leermakers, E. T. M., Darweesh, S. K. L., Baena, C. P., Moreira, E. M., van Lent, D. M., Tielemans, M. J., Muka, T., Vitezova, A., Chowdhury, R., Bramer, W. M., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.120931 · Cited by 175
Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling
van der Vliet, A., Janssen-Heininger, Y. M. W., & Anathy, V. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.08.001 · Cited by 174
Nutritional metabolomics and breast cancer risk in a prospective study
Playdon, M. C., Ziegler, R. G., Sampson, J. N., Stolzenberg‐Solomon, R. Z., Thompson, H. J., Irwin, M. L., Mayne, S. T., Hoover, R. N., & Moore, S. C. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.150912 · Cited by 165
Trace minerals intake: Risks and benefits for cardiovascular health
Mohammadifard, N., Humphries, K. H., Gotay, C. C., Mena‐Sánchez, G., Salas‐Salvadó, J., Esmaillzadeh, A., Ignaszewski, A. P., & Sarrafzadegan, N. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1406332 · Cited by 169
Dual targeting of the thioredoxin and glutathione systems in cancer and HIV
Benhar, M., Shytaj, I. L., Stamler, J. S., & Savarino, A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85339 · Cited by 170
Dietary supplements and risk of cause-specific death, cardiovascular disease, and cancer: a systematic review and meta-analysis of primary prevention trials
Schwingshackl, L., Boeing, H., Stelmach-Mardas, M., Gottschald, M., Dietrich, S., Hoffmann, G., & Chaimani, A. (2017) · Advances in Nutrition · doi:10.3945/an.116.013516 · Cited by 165
Hormetic Effects of Phytochemicals on Health and Longevity
Martel, J., Ojcius, D. M., Ko, Y., Ke, P., Wu, C.-Y., Peng, H., & Young, J. D. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.04.001 · Cited by 168
Vitamin, Mineral, and Multivitamin Supplements for the Primary Prevention of Cardiovascular Disease and Cancer: U.S. Preventive Services Task Force Recommendation Statement
Moyer, V. A., & on behalf of the U.S. Preventive Services Task Force* (2014) · Annals of Internal Medicine · doi:10.7326/m14-0198 · Cited by 171
Reactive Oxygen Species Bridge the Gap between Chronic Inflammation and Tumor Development
Yu, W., Tu, Y., Long, Z., Liu, J., Kong, D., Peng, J., Wu, H., Zheng, G., Zhao, J., Chen, Y., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2606928 · Cited by 168
Patterns of dietary supplement use among college students
Lieberman, H. R., Marriott, B. P., Williams, C., Judelson, D. A., Glickman, E. L., Geiselman, P. J., Dotson, L., & Mahoney, C. R. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.10.010 · Cited by 168
Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review
Anik, M. I., Mahmud, N., Masud, A. A., Khan, M. I., Islam, M. N., Uddin, S., & Hossain, M. K. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00411 · Cited by 163
Importance of Nutrients and Nutrient Metabolism on Human Health.
Chen, Y., Michalak, M., & Agellon, L. B. (2018) · Europe PMC (PubMed Central) · Cited by 155
Selenium for preventing cancer
Vinceti, M., Dennert, G., Crespi, C. M., Zwahlen, M., Brinkman, M. T., Zeegers, M. P., Horneber, M., D’Amico, R., & Giovane, C. D. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005195.pub3 · Cited by 151
Oxidative stress in asthma: Part of the puzzle
Şahiner, Ü. M., Birben, E., ERZURUM, S. C., Saçkesen, C., & Kalaycı, Ö. (2018) · Pediatric Allergy and Immunology · doi:10.1111/pai.12965 · Cited by 150
Selenium, antioxidants, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials
Jenkins, D. J. A., Kitts, D. D., Giovannucci, E. L., Sahye‐Pudaruth, S., Paquette, M. A., Mejía, S. B., Patel, D. K., Kavanagh, M. E., Tsirakis, T., Kendall, C. W. C., et al. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa245 · Cited by 151
Interplay Between Reactive Oxygen Species and MicroRNAs in Cancer
He, J., & Jiang, B. (2016) · Current Pharmacology Reports · doi:10.1007/s40495-016-0051-4 · Cited by 146
Pollution and respiratory disease: can diet or supplements help? A review
Whyand, T., Hurst, J. R., Beckles, M. A., & Caplin, M. E. (2018) · Respiratory Research · doi:10.1186/s12931-018-0785-0 · Cited by 143
The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia
Sillar, J. R., Germon, Z. P., Iuliis, G. N. D., & Dun, M. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236003 · Cited by 139
Nutritional Supplements and Cancer: Potential Benefits and Proven Harms
Harvie, M. (2014) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2014.34.e478 · Cited by 139
Reduction in mitochondrial iron alleviates cardiac damage during injury
Chang, H., Wu, R., Shang, M., Sato, T., Chen, C., Shapiro, J. S., Liu, T., Thakur, A., Sawicki, K. T., Prasad, S. V. N., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505748 · Cited by 137
Screening for Vitamin D Deficiency: A Systematic Review for the U.S. Preventive Services Task Force
LeBlanc, E. S., Zakher, B., Daeges, M., Pappas, M., & Chou, R. (2014) · Annals of Internal Medicine · doi:10.7326/m14-1659 · Cited by 133
Diet-Derived Circulating Antioxidants and Risk of Coronary Heart Disease
Luo, J. M., le Cessie, S., van Heemst, D., & Noordam, R. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.048 · Cited by 128
Cocrystallization of Nutraceuticals
Sinha, A. S., Maguire, A. R., & Lawrence, S. E. (2014) · Crystal Growth & Design · doi:10.1021/cg501009c · Cited by 120
Dietary Supplements—For Whom? The Current State of Knowledge about the Health Effects of Selected Supplement Use
Wierzejska, R. E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18178897 · Cited by 145
Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart
Bou‐Teen, D., Kaludercic, N., Weissman, D., Turan, B., Maack, C., Lisa, F. D., & Ruiz‐Meana, M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.043 · Cited by 119
Autophagy in Human Health and Disease: Novel Therapeutic Opportunities
Giampieri, F., Afrin, S., Forbes-Hernández, T. Y., Gasparrini, M., Cianciosi, D., Reboredo‐Rodríguez, P., Varela‐López, A., Quiles, J. L., & Battino, M. A. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7234 · Cited by 117
Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: A critical role of NADPH oxidase
Xiao, L., Liu, L., Guo, X., Zhang, S., Wang, J., Zhou, F., Liu, L., Tang, Y., & Yao, P. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.03.048 · Cited by 114
Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment
Jenkins, D. J. A., Spence, J. D., Giovannucci, E. L., Kim, Y.-I., Josse, R. G., Vieth, R., Sahye-Pudaruth, S., Paquette, M., Patel, D., Blanco Mejia, S., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.09.619 · Cited by 110
Biological, psychological and social processes that explain celebrities’ influence on patients’ health-related behaviors
Hoffman, S. J., & Tan, C. (2015) · Archives of Public Health · doi:10.1186/2049-3258-73-3 · Cited by 117
Oxidative Stress-Inducing Anticancer Therapies: Taking a Closer Look at Their Immunomodulating Effects
Loenhout, J. V., Peeters, M., Bogaerts, A., Smits, E., & Deben, C. (2020) · Antioxidants · doi:10.3390/antiox9121188 · Cited by 108
Meta-analyses including non-randomized studies of therapeutic interventions: a methodological review
Faber, T., Ravaud, P., Riveros, C., Perrodeau, É., & Dechartres, A. (2016) · BMC Medical Research Methodology · doi:10.1186/s12874-016-0136-0 · Cited by 103
Selenium-Binding Protein 1 in Human Health and Disease
Elhodaky, M., & Diamond, A. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113437 · Cited by 101
The balance between food and dietary supplements in the general population
Lentjes, M. A. H. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118002525 · Cited by 113
Addressing nutritional gaps with multivitamin and mineral supplements
Ward, E. (2014) · Nutrition Journal · doi:10.1186/1475-2891-13-72 · Cited by 96
Vitamin C supplementation for the primary prevention of cardiovascular disease
Al-Khudairy, L., Flowers, N., Wheelhouse, R., Ghannam, O., Hartley, L., Stranges, S., & Rees, K. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011114.pub2 · Cited by 94
Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions
Gómez, X., Sanon, S., Zambrano, K., Asquel, S., Bassantes, M., Morales, J. E., Otáñez, G., Pomaquero, C., Villarroel, S., Zurita, A., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00162-8 · Cited by 92
Vitamin D supplementation for chronic liver diseases in adults
Bjelaković, G., Nikolova, D., Bjelaković, M., & Gluud, C. N. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011564.pub2 · Cited by 95
Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells
Aurora, A. B., Khivansara, V., Leach, A., Gill, J. G., Martin-Sandoval, M. S., Yang, C., Kasitinon, S. Y., Bezwada, D., Tasdogan, A., Gu, W., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2120617119 · Cited by 88
Are reactive oxygen species still the basis for diabetic complications?
Marco, E. D., Jha, J. C., Sharma, A., Wilkinson‐Berka, J. L., Jandeleit-Dahm, K. A. M., & de Haan, J. B. (2015) · Clinical Science · doi:10.1042/cs20150093 · Cited by 86
Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise
MANKOWSKI, R. T., ANTON, S. D., BUFORD, T. W., & LEEUWENBURGH, C. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000620 · Cited by 83
Vitamin E: How much is enough, too much and why!
Traber, M. G., & Head, B. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.10.028 · Cited by 86
Trends in Overall and Micronutrient-Containing Dietary Supplement Use in US Adults and Children, NHANES 2007–2018
Cowan, A., Tooze, J. A., Gahche, J. J., Eicher‐Miller, H. A., Guenther, P. M., Dwyer, J. T., Potischman, N. A., Bhadra, A., Carroll, R. J., & Bailey, R. L. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac168 · Cited by 81
A systematic review and meta-analysis on the prevalence of dietary supplement use by military personnel
Knapik, J. J., Steelman, R. A., Hoedebecke, S. S., Farina, E. K., Austin, K. G., & Lieberman, H. R. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-143 · Cited by 80
Analytical ingredient content and variability of adult multivitamin/mineral products: national estimates for the Dietary Supplement Ingredient Database ,
Andrews, K. W., Roseland, J. M., Gusev, P. A., Palachuvattil, J., Dang, P. T. V., Savarala, S., Han, F., Pehrsson, P. R., Douglass, L. W., Dwyer, J. T., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.134544 · Cited by 82
The Evolving Role of Multivitamin/Multimineral Supplement Use among Adults in the Age of Personalized Nutrition
Blumberg, J. B., Bailey, R. L., Sesso, H. D., & Ulrich, C. M. (2018) · Nutrients · doi:10.3390/nu10020248 · Cited by 76
Supplementation with vitamin E alone is associated with reduced myocardial infarction: A meta-analysis
Loffredo, L., Perri, L., Castelnuovo, A. F. D., Iacoviello, L., de Gaetano, G., & Violi, F. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.01.008 · Cited by 71
Effect of long-term nutraceutical and dietary supplement use on cognition in the elderly: a 10-year systematic review of randomised controlled trials
D’Cunha, N. M., Georgousopoulou, E. N., Dadigamuwage, L., Kellett, J., Panagiotakos, D. B., Thomas, J., McKune, A. J., Mellor, D. D., & Naumovski, N. (2018) · British Journal of Nutrition · doi:10.1017/s0007114517003452 · Cited by 68
Circulating essential metals and lung cancer: Risk assessment and potential molecular effects
Bai, Y., Wang, G., Fu, W., Lu, Y., Wei, W., Chen, W., Wu, X., Meng, H., Feng, Y., Liu, Y., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.04.021 · Cited by 67
Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease
Kim, J.-S., Choi, J., Kwon, S. Y., McEvoy, J. W., Blaha, M. J., Blumenthal, R. S., Güallar, E., Zhao, D., & Michos, E. D. (2018) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.117.004224 · Cited by 66
Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment
Inglés, D. P., Rodriguez, J. B. C., & García, H. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-1270-1 · Cited by 69
Allium Vegetables and Garlic Supplements Do Not Reduce Risk of Colorectal Cancer, Based on Meta-analysis of Prospective Studies
Zhu, B., Zou, L., Qi, L., Zhong, R., & Miao, X. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.03.019 · Cited by 64
Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women
Curhan, S. G., Stanković, K. M., Eavey, R. D., Wang, M., Stampfer, M. J., & Curhan, G. C. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.109314 · Cited by 65
Relationship between Serum Magnesium Concentration and Radiographic Knee Osteoarthritis
Zeng, C., Wei, J., Li, H., Yang, T., Zhang, F., Pan, D., Xiao, Y., Yang, T.-B., & Lei, G. (2015) · The Journal of Rheumatology · doi:10.3899/jrheum.141414 · Cited by 64
A blueprint for the primary prevention of cancer: Targeting established, modifiable risk factors
Gapstur, S. M., Drope, J. M., Jacobs, E. J., Teras, L. R., McCullough, M. L., Douglas, C. E., Patel, A. V., Wender, R. C., & Brawley, O. W. (2018) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21496 · Cited by 69
Antioxidant vitamins and their effect on immune system
Khadim, R. M., & Al-Fartusie, F. S. D. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1853/1/012065 · Cited by 75
Use of complementary medicine products: a nationally representative cross-sectional survey of 2019 Australian adults
Harnett, J., McIntyre, E., Steel, A., Foley, H., Sibbritt, D. W., & Adams, J. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-024198 · Cited by 62

Authors: Fortmann, S. P., Burda, B. U., Senger, C. A., Lin, J. S., & Whitlock, E. P.
Affiliations: Kaiser Permanente Center for Health Research (US)
ORCID: Fortmann, Stephen P.
Lin, Jennifer S.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 2013-12
Volume: 159
Issue: 12
Pages: 824-834
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-159-12-201312170-00729
OpenAlex: W2168613688
Cited by: 442
References: 91
Citations by year: 2026: 14 · 2025: 14 · 2024: 31 · 2023: 29 · 2022: 30 · 2021: 46 · 2020: 29 · 2019: 28 · 2018: 43 · 2017: 41 · 2016: 36 · 2015: 41 · 2014: 58 · 2013: 2
FWCI: 6.53
Type: journal article
Language: en
Open access: closed
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (HHS-290-2007-10057-I)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: vitamin supplements, mineral supplements, multivitamins, cardiovascular disease prevention, cancer prevention, primary prevention, vitamin E, beta-carotene, selenium, calcium, folic acid, vitamin A, vitamin C, vitamin D
MeSH terms: Cardiovascular Diseases, Humans, Minerals, Neoplasms, Primary Prevention, Vitamins, Incidence, Dietary Supplements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks