Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force

Introduction to Meta‐Analysis

Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2021) · doi:10.1002/9781119558378 · Cited by 9,799

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737

Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease

Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

Clark, L. (1996) · JAMA · doi:10.1001/jama.276.24.1957 · Cited by 2,988

Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease

Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M., Rosner, B., Cook, N. R., Belanger, C., LaMotte, F., Gaziano, J. M., Ridker, P. M., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341801 · Cited by 2,397

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

Lippman, S. M., Klein, E. A., Goodman, P. J., Lucia, M. S., Thompson, I. M., Ford, L. G., Parnes, H. L., Minasian, L. M., Gaziano, J. M., Hartline, J. A., et al. (2008) · JAMA · doi:10.1001/jama.2008.864 · Cited by 2,164

Vitamin E and the Risk of Prostate Cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Klein, E. A., Thompson, I. M., Tangen, C. M., Crowley, J. J., Lucia, M. S., Goodman, P. J., Minasian, L. M., Ford, L. G., Parnes, H. L., Gaziano, J. M., et al. (2011) · JAMA · doi:10.1001/jama.2011.1437 · Cited by 1,787

Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial

Lappe, J. M., Travers‐Gustafson, D., Davies, K. M., Recker, R. R., & Heaney, R. P. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.6.1586 · Cited by 1,445

Effect of four monthly oral vitamin D 3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial

Trivedi, D. P., Doll, R., & Khaw, K. (2003) · BMJ · doi:10.1136/bmj.326.7387.469 · Cited by 1,273

Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer: The Women’s Health Study: A Randomized Controlled Trial

Lee, I.-M., Cook, N. R., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., & Buring, J. E. (2005) · JAMA · doi:10.1001/jama.294.1.56 · Cited by 1,137

A Novel Promising Frontier for Human Health: The Beneficial Effects of Nutraceuticals in Cardiovascular Diseases

Carrizzo, A., Izzo, C., Forte, M., Sommella, E., Pietro, P. D., Venturini, E., Ciccarelli, M., Galasso, G., Rubattu, S. D., Campiglia, P., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228706 · Cited by 65

The Use of Multivitamin/Multimineral Supplements: A Modified Delphi Consensus Panel Report

Blumberg, J. B., Cena, H., Barr, S. I., Biesalski, H. K., Uauy, R. D., Delaney, B. C., Frei, B. B., González, M. I. M., Hwalla, N. C., Lategan-Potgieter, R., et al. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.02.014 · Cited by 63

The Determining Role of Mitochondrial Reactive Oxygen Species Generation and Monoamine Oxidase Activity in Doxorubicin-Induced Cardiotoxicity

Antonucci, S., Sante, M. D., Tonolo, F., Pontarollo, L., Scalcon, V., Alánová, P., Menabò, R., Carpi, A., Bindoli, A., Rigobello, M. P., et al. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7929 · Cited by 67

Electrolyte minerals intake and cardiovascular health

Mohammadifard, N., Gotay, C. C., Humphries, K. H., Ignaszewski, A., Esmaillzadeh, A., & Sarrafzadegan, N. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1453474 · Cited by 63

Consequences of Inadequate Intakes of Vitamin A, Vitamin B12, Vitamin D, Calcium, Iron, and Folate in Older Persons

Watson, J., Lee, M., & Garcia‐Casal, M. N. (2018) · Current Geriatrics Reports · doi:10.1007/s13670-018-0241-5 · Cited by 60

Mitochondria-Targeted Antioxidants and Skeletal Muscle Function

Broome, S. C., Woodhead, J. S. T., & Merry, T. L. (2018) · Antioxidants · doi:10.3390/antiox7080107 · Cited by 64

Effects of Nutrition Intervention on Total and Cancer Mortality: 25-Year Post-trial Follow-up of the 5.25-Year Linxian Nutrition Intervention Trial

Wang, S., Taylor, P. R., Fan, J., Pfeiffer, R. M., Gail, M. H., He, L., Murphy, G. A., Dawsey, S. M., Qiao, Y., & Abnet, C. C. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy043 · Cited by 58

Antioxidant Supplementation on Cancer Risk and During Cancer Therapy: An Update

Özben, T. (2014) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666141209160918 · Cited by 57

Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention

Irimie, A. I., Braicu, C., Paşca, S., Magdo, L., Gulei, D., Cojocneanu, R., Ciocan, C. A., Olariu, A., Coza, O. F., & Berindan‐Neagoe, I. (2019) · Medicina · doi:10.3390/medicina55060283 · Cited by 57

Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment

Sunkara, A., & Raizner, A. E. (2019) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-15-3-179 · Cited by 58

Iron toxicity and its possible association with treatment of Cancer: Lessons from hemoglobinopathies and rare, transfusion-dependent anemias

Puliyel, M. M., Mainous, A. G., Berdoukas, V. A., & Coates, T. D. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.861 · Cited by 54

Natural Products for Cancer Prevention: Clinical Update 2016

Sanders, K., Moran, Z. R., Shi, Z., Paul, R., & Greenlee, H. (2016) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2016.06.001 · Cited by 56

Oxidative Stress and Microglial Response in Retinitis Pigmentosa

Murakami, Y., Nakabeppu, Y., & Sonoda, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197170 · Cited by 57

β-Carotene Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yang, J., Zhang, Y., Na, X., & Zhao, A. (2022) · Nutrients · doi:10.3390/nu14061284 · Cited by 54

Exercise, Immune System, Nutrition, Respiratory and Cardiovascular Diseases during COVID-19: A Complex Combination

Scudiero, O., Lombardo, B., Brancaccio, M., Mennitti, C., Cesaro, A., Fimiani, F., Gentile, L., Moscarella, E., Amodio, F., Ranieri, A., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18030904 · Cited by 52

Vitamin D and health: The need for more randomized controlled trials

Jorde, R., & Grimnes, G. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.01.021 · Cited by 53

Agronomic biofortification of plant foods with minerals, vitamins and metabolites with chemical fertilizers and liming

Prasad, R., & Shivay, Y. S. (2020) · Journal of Plant Nutrition · doi:10.1080/01904167.2020.1738464 · Cited by 53

Multivitamins in the prevention of cancer and cardiovascular disease: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial

Sesso, H. D., Rist, P. M., Aragaki, A. K., Rautiainen, S., Johnson, L. G., Friedenberg, G., Copeland, T., Clar, A., Mora, S., Moorthy, M. V., et al. (2022) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac056 · Cited by 51

Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety

Lan, A., Li, W., Liu, Y., Xiong, Z., Zhang, X., Zhou, S., Palko, O., Chen, H., Kapita, M., Prigge, J. R., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10609 · Cited by 51

Association between Dietary Zinc Intake and Hyperuricemia among Adults in the United States

Zhang, Y., Liu, Y., & Qiu, H. (2018) · Nutrients · doi:10.3390/nu10050568 · Cited by 51

N, S, I co-doped carbon dots for folic acid and temperature sensing and applied to cellular imaging.

Zhao, M., Huaa, J., & Yanga, Y. (2020) · Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2019.117444 · Cited by 46

An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses

Kim, J. Y., Song, M., Kim, M. S., Natarajan, P., Do, R., Myung, W., & Won, H. (2023) · BMC Medicine · doi:10.1186/s12916-023-03018-y · Cited by 51

Should We ‘Eat a Rainbow’? An Umbrella Review of the Health Effects of Colorful Bioactive Pigments in Fruits and Vegetables

Blumfield, M., Mayr, H. L., de Vlieger, N., Abbott, K. A., Starck, C. S., Fayet‐Moore, F., & Marshall, S. (2022) · Molecules · doi:10.3390/molecules27134061 · Cited by 58

Selenoproteins in human body: focus on thyroid pathophysiology

Valea, A., & Georgescu, C. E. (2018) · HORMONES · doi:10.1007/s42000-018-0033-5 · Cited by 48

The Sleep Apnea cardioVascular Endpoints (SAVE) Trial: Rationale, Ethics, Design, and Progress

Antic, N. A., Heeley, E. L., Anderson, C. S., Luo, Y., Wang, J., Neal, B. C., Grunstein, R. R., Barbé, F., Lorenzi‐Filho, G., Huang, S., et al. (2015) · SLEEP · doi:10.5665/sleep.4902 · Cited by 48

Exercise training as a drug to treat age associated frailty

Viña, J., Salvador‐Pascual, A., Tarazona‐Santabalbina, F. J., Rodríguez‐Mañas, L., & Gómez‐Cabrera, M. C. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.024 · Cited by 45

Bad company: Microenvironmentally mediated resistance to targeted therapy in melanoma

Almeida, F. V., Douglass, S. M., Fane, M. E., & Weeraratna, A. T. (2018) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12736 · Cited by 47

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

Gligorijević, N., Stanić-Vučinić, D., Radomirović, M., Stojadinović, M., Olgica, N., Khulal, U., & Veličković, T. Ć. (2021) · Molecules · doi:10.3390/molecules26102834 · Cited by 48

Vitamin D supplementation for chronic liver diseases in adults

Bjelaković, M., Nikolova, D., Bjelaković, G., & Gluud, C. N. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011564.pub3 · Cited by 49

Antioxidant capacity of foods for scavenging reactive oxidants and inhibition of plasma lipid oxidation induced by multiple oxidants

Niki, E. (2016) · Food & Function · doi:10.1039/c6fo00275g · Cited by 44

Association between low dietary zinc and hyperuricaemia in middle-aged and older males in China: a cross-sectional study

Xie, D., Xiong, Y., Zeng, C., Wei, J., Yang, T., Li, H., Wang, Y., Gao, S., Li, Y., & Lei, G. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008637 · Cited by 44

Representations of the health value of vitamin D supplementation in newspapers: media content analysis

Caulfield, T., Clark, M. I., McCormack, J. P., Rachul, C., & Field, C. J. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-006395 · Cited by 41

Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis

Antonucci, S., Mulvey, J. F., Burger, N., Sante, M. D., Hall, A. R., Hinchy, E. C., Caldwell, S. T., Gruszczyk, A. V., Deshwal, S., Hartley, R. C., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.01.034 · Cited by 44

Folate, Vitamin B6 and Vitamin B12 Intake in Relation to Hyperuricemia

Zhang, Y., & Qiu, H. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7080210 · Cited by 41

Vitamin E Supplementation and Mortality in Healthy People: A Meta-Analysis of Randomised Controlled Trials

Curtis, A. J., Bullen, M., Piccenna, L. G., & McNeil, J. J. (2014) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-014-6560-7 · Cited by 41

Survivorship: Nutrition and Weight Management, Version 2.2014

Denlinger, C. S., Ligibel, J. A., Are, M., Baker, K. S., Demark‐Wahnefried, W., Dizon, D. S., Friedman, D. L., Goldman, M. E., Jones, L. W., King, A. A., et al. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0137 · Cited by 40

Antioxidants in smokers

Astori, E., Garavaglia, M. L., Colombo, G., Landoni, L., Portinaro, N. M., Milzani, A., & Dalle‐Donne, I. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000093 · Cited by 43

Knowledge about dietary supplements and trust in advertising them: Development and validation of the questionnaires and preliminary results of the association between the constructs

Karbownik, M. S., Paul, E., Nowicka, M., Nowicka, Z., Kowalczyk, R. P., Kowalczyk, E., & Pietras, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218398 · Cited by 42

The Association Between Dietary Antioxidant Micronutrients and Cardiovascular Disease in Adults in the United States: A Cross-Sectional Study

Yin, T., Zhu, X., Xu, D. R., Lin, H., Lu, X., Tang, Y., Shi, M., Yao, W., Zhou, Y., Zhang, H., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.799095 · Cited by 38

The Role of Vitamin Supplementation in the Prevention of Cardiovascular Disease Events

Desai, C., Huang, J. J., Lokhandwala, A. M., Fernandez, A., Riaz, I. B., & Alpert, J. S. (2014) · Clinical Cardiology · doi:10.1002/clc.22299 · Cited by 37

Multivitamin-Mineral Use Is Associated with Reduced Risk of Cardiovascular Disease Mortality among Women in the United States

Bailey, R. L., Fakhouri, T. H. I., Park, Y., Dwyer, J. T., Thomas, P. R., Gahche, J. J., Miller, P. E., Dodd, K. W., Sempos, C. T., & Murray, D. M. (2015) · Journal of Nutrition · doi:10.3945/jn.114.204743 · Cited by 36

Update on the Methods of the U.S. Preventive Services Task Force: Methods for Understanding Certainty and Net Benefit When Making Recommendations

Krist, A. H., Wolff, T., Jonas, D. E., Harris, R., LeFevre, M. L., Kemper, A. R., Mangione, C. M., Tseng, C., & Grossman, D. C. (2017) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2017.09.011 · Cited by 36

Vitamin C intake and multiple health outcomes: an umbrella review of systematic reviews and meta-analyses

Xu, K., Peng, R., Zou, Y., Jiang, X., Sun, Q., & Song, C. (2022) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2022.2048359 · Cited by 37

Prospective association between red and processed meat intakes and breast cancer risk: modulation by an antioxidant supplementation in the SU.VI.MAX randomized controlled trial

Pouchieu, C., Deschasaux, M., Herçberg, S., Druesne‐Pecollo, N., Latino‐Martel, P., & Touvier, M. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu134 · Cited by 35

COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials

Hall, K. T., Buring, J. E., Mukamal, K. J., Moorthy, M. V., Wayne, P. M., Kaptchuk, T. J., Battinelli, E. M., Ridker, P. M., Sesso, H. D., Weinstein, S. J., et al. (2018) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djy204 · Cited by 34

Dietary Supplement Use in Middle-aged and Older Adults

Tan, E. C. K., Eshetie, T. C., Gray, S. L., & Marcum, Z. A. (2022) · The journal of nutrition health & aging · doi:10.1007/s12603-022-1732-9 · Cited by 34

Lead Exposure, B Vitamins, and Plasma Homocysteine in Men 55 Years of Age and Older: The VA Normative Aging Study

Bakulski, K. M., Park, S. K., Weisskopf, M. G., Tucker, K. L., Sparrow, D., Spiro, A., Vokonas, P., Nie, L. H., Hu, H., & Weuve, J. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1306931 · Cited by 33

Cancer in the Medically Underserved Population

Olaku, O. O., & Taylor, E. A. (2017) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2016.09.020 · Cited by 32

Selenium intake and metabolic syndrome: A systematic review

Retondario, A., Fernandes, R., Rockenbach, G., Alves, M. D. A., Bricarello, L. P., Trindade, E. B. S. D. M., & de Vasconcelos, F. D. A. G. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.02.021 · Cited by 31

Efficacy of Multivitamin/mineral Supplementation to Reduce Chronic Disease Risk: A Critical Review of the Evidence from Observational Studies and Randomized Controlled Trials

Angelo, G., Drake, V., & Frei, B. B. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.912199 · Cited by 30

Vitamin E in Cancer Treatment: A Review of Clinical Applications in Randomized Control Trials

Donnelly, J., Appathurai, A., Yeoh, H., Driscoll, K., & Faisal, W. (2022) · Nutrients · doi:10.3390/nu14204329 · Cited by 30

Vitamin K and Hallmarks of Ageing: Focus on Diet and Gut Microbiome

Dai, L., Mafra, D., Shiels, P. G., Hackeng, T. M., Stenvinkel, P., & Schurgers, L. J. (2023) · Nutrients · doi:10.3390/nu15122727 · Cited by 32

Glutathione Dynamics in the Tumor Microenvironment: A Potential Target of Cancer Stem Cells and T Cells

Park, Y., & Jeong, E. M. (2024) · International Journal of Stem Cells · doi:10.15283/ijsc24060 · Cited by 31

The Roles of Vitamins in Diabetic Retinopathy: A Narrative Review

Ruamviboonsuk, V., & Grzybowski, A. E. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216490 · Cited by 29

Oxidative stress and the unfulfilled promises of antioxidant agents

Giorgio, M. (2015) · ecancermedicalscience · doi:10.3332/ecancer.2015.556 · Cited by 27

Complementary and alternative medicine use among Iranian patients attending urban outpatient general practices

Behnood‐Rod, A., Khoshkbejari, M. A. P., Pourzargar, P., Hassanzadeh, M., Moharamzad, Y., & Foroughi, F. (2017) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2017.12.008 · Cited by 28

Dietary supplements consumption and its association with socioeconomic factors, obesity and main non-communicable chronic diseases in the north of Iran: the PERSIAN Guilan Cohort Study (PGCS)

Mahdavi‐Roshan, M., Rezazadeh, A., Joukar, F., Khorshidi, Y., Naghipour, M., & Mansour‐Ghanaei, F. (2021) · BMC Nutrition · doi:10.1186/s40795-021-00488-2 · Cited by 28

Targeting oxidant-dependent mechanisms for the treatment of respiratory diseases and their comorbidities

Thomson, N. C. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.11.013 · Cited by 28

Vitamin D and chronic disease prevention

Welsh, P. I., & Sattar, N. A. (2014) · BMJ · doi:10.1136/bmj.g2280 · Cited by 27

Different Socio-Demographic and Lifestyle Factors Can Determine the Dietary Supplement Use in Children and Adolescents in Central-Eastern Poland

Sicińska, E., Pietruszka, B., Januszko, O., & Kałuża, J. (2019) · Nutrients · doi:10.3390/nu11030658 · Cited by 26

Association of dietary vitamin E intake with risk of lung cancer: a dose-response meta-analysis.

Zhu, Y., Bo, Y., Liu, X., & Qiu, C. (2017) · PubMed · doi:10.6133/apjcn.032016.04 · Cited by 26

The association between circulating IGF1, IGFBP3, and calcium: results from NHANES III

Hemelrijck, M. V., Shanmugalingam, T., Bosco, C., Wulaningsih, W., & Rohrmann, S. (2015) · Endocrine Connections · doi:10.1530/ec-15-0039 · Cited by 24

Silibinin administration improves hepatic failure due to extensive liver infiltration in a breast cancer patient.

Bosch‐Barrera, J., Corominas-Faja, B., Cuyàs, E., Martı́n-Castillo, B., Brunet, J., & Menéndez, J. A. (2014) · PubMed · Cited by 25

Choosing Wisely® in Preventive Medicine

Livingston, C. J., Freeman, R. J., Mohammad, A., Costales, V. C., Titus, T. M., Harvey, B. J., & Sherin, K. M. (2016) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2016.03.009 · Cited by 24

Association between Dietary Magnesium Intake and Hyperuricemia

Wang, Y., Zeng, C., Wei, J., Yang, T., Li, H., Deng, Z., Yang, Y., Zhang, Y., Ding, X., Xie, D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141079 · Cited by 24

Dietary Supplements: Types, Health Benefits, Industry and Regulation

Hassan, S., Egbuna, C., Tijjani, H., Ifemeje, J. C., Olisah, M. C., Patrick-Iwuanyanwu, K. C., Onyeike, P. C., & Ephraim-Emmanuel, B. C. (2020) · Springer eBooks · doi:10.1007/978-3-030-42319-3_3 · Cited by 30

Serum calcium and 25-hydroxyvitamin D in relation to longevity, cardiovascular disease and cancer: a Mendelian randomization study

Yuan, S., Baron, J. A., Michaëlsson, K., & Larsson, S. C. (2021) · npj Genomic Medicine · doi:10.1038/s41525-021-00250-4 · Cited by 24

Lifestyle, Eating Habits, and Health Behaviors Among Dietary Supplement Users in Three European Countries

Iłowiecka, K., Maślej, M., Czajka, M., Pawłowski, A., Więckowski, P., Styk, T., Gołkiewicz, M., Kuzdraliński, A., & Koch, W. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.892233 · Cited by 23

Reprint of: Cardiovascular Disease Prevention by Diet Modification

Yu, E., Malik, V., & Hu, F. B. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.10.019 · Cited by 27

Role/s of ‘Antioxidant’ Enzymes in Ageing

Veal, E. A., Jackson, T., & Latimer, H. R. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_14 · Cited by 25

Dietary supplements in the USA: problematic trends

Denham, B. E. (2021) · Public Health Nutrition · doi:10.1017/s1368980021000665 · Cited by 22

Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in High Glucose-Induced Apoptosis in Rat Cardiac Myocytes and Murine Pancreatic β-Cells

Yao, T., Fujimura, T., Murayama, K., Okumura, K., & Seko, Y. (2017) · Cells · doi:10.3390/cells6040035 · Cited by 22

Selenium Level in Patients with Heart Failure versus Normal Individuals

Mirdamadi, A., Rafiei, R., Kahazaipour, G., & Fouladi, L. (2019) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_45_18 · Cited by 21

The role of different nutrients in the prevention and treatment of cardiovascular diseases

Tu, Z., Yang, J.-F., & Fan, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1393378 · Cited by 26

Large-scale randomized clinical trials of bioactives and nutrients in relation to human health and disease prevention - Lessons from the VITAL and COSMOS trials

Rautiainen, S., Sesso, H. D., & Manson, J. E. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.12.001 · Cited by 19

Causal associations between dietary antioxidant vitamin intake and lung cancer: A Mendelian randomization study

Zhao, H., & Jin, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.965911 · Cited by 19

Dual functional roles of nutritional additives in nutritional fortification and safety of thermally processed food: Potential, limitations, and perspectives

Shi, B., Wang, H., Nawaz, A., Khan, I. A., Wang, Q., Zhao, D., & Cheng, K. (2023) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13268 · Cited by 21

Effect of Baseline Nutritional Status on Long-term Multivitamin Use and Cardiovascular Disease Risk

Rautiainen, S., Gaziano, J. M., Christen, W. G., Bubes, V. Y., Kotler, G., Glynn, R. J., Manson, J. E., Buring, J. E., & Sesso, H. D. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.0176 · Cited by 19

Micronutrient deficiencies, vitamin pills and nutritional supplements

Combet, E., & Buckton, C. H. (2014) · Medicine · doi:10.1016/j.mpmed.2014.11.002 · Cited by 19

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(2015)

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