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Cited by 442Nutrition and Health StudiesAntioxidant Activity and Oxidative StressNutritional Studies and Diet

The DOI matches its Crossref record; 90 of the 91 references it cites were found in a registry or an index.

Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force

Fortmann, Stephen P., Burda, Brittany U., Senger, Caitlyn A., Lin, Jennifer S., Whitlock, Evelyn P.·2013·Annals of Internal Medicine
DOI 10.7326/0003-4819-159-12-201312170-00729
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Abstract

BACKGROUND: Vitamin and mineral supplements are commonly used to prevent chronic diseases. PURPOSE: To systematically review evidence for the benefit and harms of vitamin and mineral supplements in community-dwelling, nutrient-sufficient adults for the primary prevention of cardiovascular disease (CVD) and cancer. DATA SOURCES: MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Database of Abstracts of Reviews of Effects were searched from January 2005 to 29 January 2013, with manual searches of reference lists and gray literature. STUDY SELECTION: Two investigators independently selected and reviewed fair- and good-quality trials for benefit and fair- and good-quality trials and observational studies for harms. DATA EXTRACTION: Dual quality assessments and data abstraction. DATA SYNTHESIS: Two large trials (n = 27 658) reported lower cancer incidence in men taking a multivitamin for more than 10 years (pooled unadjusted relative risk, 0.93 [95% CI, 0.87 to 0.99]). The study that included women showed no effect in that group. High-quality studies (k = 24; n = 324 653) of single and paired nutrients (such as vitamins A, C, or D; folic acid; selenium; or calcium) were scant and heterogeneous and showed no clear evidence of benefit or harm. Neither vitamin E nor β-carotene prevented CVD or cancer, and β-carotene increased lung cancer risk in smokers. LIMITATIONS: The analysis included only primary prevention studies in adults without known nutritional deficiencies. Studies were conducted in older individuals and included various supplements and doses under the set upper tolerable limits. Duration of most studies was less than 10 years. CONCLUSION: Limited evidence supports any benefit from vitamin and mineral supplementation for the prevention of cancer or CVD. Two trials found a small, borderline-significant benefit from multivitamin supplements on cancer in men only and no effect on CVD. PRIMARY FUNDING SOURCE: Agency for Healthcare Research and Quality.

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Crossref · 10.7326/0003-4819-159-12-201312170-00729

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Citations

Cites

Show all 91 references

Research works printed but not linked: 12

  1. Gahche J, 2011, NCHS Data Brief, 1
  2. Huang HY, 2006, Evid Rep Technol Assess (Full Rep), 1
  3. 10.1001/jama.1996.03540240035027 · DOI
  4. Moon TE, 1997, Cancer Epidemiol Biomarkers Prev, 6, 949
  5. Levine N, 1997, Cancer Epidemiol Biomarkers Prev, 6, 957
  6. Hercberg S, 1998, Int J Vitam Nutr Res, 68, 3
  7. Bjelakovic G, 2008, Cochrane Database Syst Rev, CD004183
  8. Bjelakovic G, 2008, Cochrane Database Syst Rev, CD007176
  9. Rees K, 2013, Cochrane Database Syst Rev, 1, CD009671
  10. Alkhenizan A, 2007, Ann Saudi Med, 27, 409
  11. Ford JA, 2012, Circulation, 126, A18397
  12. Duffield-Lillico AJ, 2002, Cancer Epidemiol Biomarkers Prev, 11, 630

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Metadata

Authors
Fortmann, S. P., Burda, B. U., Senger, C. A., Lin, J. S., & Whitlock, E. P.
Affiliations
Kaiser Permanente Center for Health Research (US)
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2013-12
Volume
159
Issue
12
Pages
824-834
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-159-12-201312170-00729
OpenAlex
W2168613688
Cited by
442
References
91
Citations by year
2026: 14 · 2025: 14 · 2024: 31 · 2023: 29 · 2022: 30 · 2021: 46 · 2020: 29 · 2019: 28 · 2018: 43 · 2017: 41 · 2016: 36 · 2015: 41 · 2014: 58 · 2013: 2
FWCI
6.53
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service (HHS-290-2007-10057-I)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
vitamin supplements, mineral supplements, multivitamins, cardiovascular disease prevention, cancer prevention, primary prevention, vitamin E, beta-carotene, selenium, calcium, folic acid, vitamin A, vitamin C, vitamin D
MeSH terms
Cardiovascular Diseases, Humans, Minerals, Neoplasms, Primary Prevention, Vitamins, Incidence, Dietary Supplements

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