Observations on metabolism of aldosterone in man

EVIDENCE FOR SECRETION OF AN ALDOSTERONE-STIMULATING HORMONE BY THE KIDNEY*

Davis, J. O., Carpenter, C. C. J., Ayers, C. R., Holman, J. E., & Bahn, R. C. (1961) · Journal of Clinical Investigation · doi:10.1172/jci104301 · Cited by 169 · see citing works

THE METABOLIC CLEARANCE RATE OF ALDOSTERONE IN PREGNANT AND NONPREGNANT SUBJECTS ESTIMATED BY BOTH SINGLE-INJECTION AND CONSTANT-INFUSION METHODS*

Tait, J. F., Little, B., Tait, S. A. S., & Flood, C. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104667 · Cited by 157 · see citing works

THE METABOLISM OF ALDOSTERONE IN NORMAL SUBJECTS AND IN PATIENTS WITH HEPATIC CIRRHOSIS*

Coppage, W. S., Island, D. P., Cooner, A. E., & Liddle, G. W. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104624 · Cited by 151 · see citing works

THE EFFECT OF THE UPRIGHT POSTURE UPON HEPATIC BLOOD FLOW IN NORMOTENSIVE AND HYPERTENSIVE SUBJECTS 1

Culbertson, J. W., Wilkins, R. W., Ingelfinger, F. J., & Bradley, S. E. (1951) · Journal of Clinical Investigation · doi:10.1172/jci102445 · Cited by 131 · see citing works

AN ESTIMATION OF THE HEPATIC BLOOD FLOW AND SPLANCHNIC OXYGEN CONSUMPTION IN HEART FAILURE 1

Myers, J. D., & Hickam, J. B. (1948) · Journal of Clinical Investigation · doi:10.1172/jci102008 · Cited by 126 · see citing works

ALDOSTERONE SECRETION AND METABOLISM IN NORMAL MEN AND WOMEN AND IN PREGNANCY

Jones, K. M., Lloyd‐Jones, R. L., Riondel, A. M., Tait, J. F., Tait, S. A. S., Bulbrook, R. D., & Greenwood, F. C. (1959) · European Journal of Endocrinology · doi:10.1530/acta.0.0300321 · Cited by 125 · see citing works

Interrelationships Between Angiotensin, Norepinephrine, Epinephrine, Aldosterone Secretion, and Electrolyte Metabolism in Man

Laragh, J. H. (1962) · Circulation · doi:10.1161/01.cir.25.1.203 · Cited by 124 · see citing works

The Secretion and Metabolism of Cortisol and Aldosterone in Normal and in Steroid-Treated Women*

LAYNE, D., Meyer, C. J., VAISHWANAR, P. S., & Pincus, G. (1962) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-22-2-107 · Cited by 120 · see citing works

Isolation of crystalline aldosterone from the urine of a nephrotic patient

Luetscher, J. A., Neher, R., & Wettstein, A. (1954) · Cellular and Molecular Life Sciences · doi:10.1007/bf02170397 · Cited by 117 · see citing works

AN INVESTIGATION OF THE URINARY METABOLITES AND SECRETION RATES OF ALDOSTERONE AND CORTISOL IN MAN AND A DESCRIPTION OF METHODS FOR THEIR MEASUREMENT

Flood, C., Layne, D. S., Ramcharan, S., Rossipal, E., Tait, J. F., & Tait, S. A. S. (1961) · European Journal of Endocrinology · doi:10.1530/acta.0.0360237 · Cited by 114 · see citing works

METABOLISM OF FREE AND CONJUGATED 17-HYDROXYCORTICOSTEROIDS IN SUBJECTS WITH THYROID DISEASE*

Brown, H., Englert, E., & Wallach, S. (1958) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-18-2-167 · Cited by 88 · see citing works

Aldosterone in Urine of Normal Man and of Patients with Oedema

Axelrad, B. J., Cates, J. E., Johnson, B. B., & Luetscher, J. A. (1955) · BMJ · doi:10.1136/bmj.1.4907.196 · Cited by 82 · see citing works

THE EFFECTS OF CHRONIC HEPATIC VENOUS CONGESTION ON THE METABOLISM OF d,l-ALDOSTERONE AND d-ALDOSTERONE*

Ayers, C. R., Davis, J. O., Lieberman, F., Carpenter, C. C. J., & Berman, M. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104545 · Cited by 77 · see citing works

Increased Aldosterone Secretion in Response to Blood Loss

FARRELL, G. L., Rosnagle, R. S., Rauschkolb, E. W., Banks, R. C., & Saleliar, M. (1956) · Circulation Research · doi:10.1161/01.res.4.5.606 · Cited by 61 · see citing works

METABOLISM OF FREE AND CONJUGATED 17-HYDROXYCORTICOSTEROIDS IN SUBJECTS WITH LIVER DISEASE*

Englert, E., Brown, H., Wallach, S., & Simons, E. L. (1957) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-17-12-1395 · Cited by 50 · see citing works

ALDOSTERONE METABOLISM IN LIVER DISEASE

Hurter, R., & Nabarro, J. D. N. (1960) · European Journal of Endocrinology · doi:10.1530/acta.0.xxxiii0168 · Cited by 36 · see citing works

Role of the Kidney in Adrenocortical Response to Hemorrhage in Hypophysectomized Dogs

Ganong, W. F., & Mulrow, P. J. (1962) · Endocrinology · doi:10.1210/endo-70-2-182 · Cited by 36 · see citing works

Determination of the Secretion Rate of Aldosterone in Normal Man by Use of 7-H3-d-Aldosterone and Acid Hydrolysis of Urine*

Siegenthaler, W. E., Dowdy, A. J., & Luetscher, J. A. (1962) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-22-2-172 · Cited by 36 · see citing works

Impairment of the Enzymatic Inactivation of Adrenal Cortical Hormones Following Passive Venous Congestion of the Liver

Yates, F. E., Urquhart, J., & Herbst, A. L. (1958) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1958.194.1.65 · Cited by 36 · see citing works

Aldosterone Secretion and Metabolism in Hyperthyroidism and Myxedema1

Luetscher, J. A., Cohn, A., CAMARGO, C. A., Dowdy, A. J., & CALLAGHAN, A. M. (1963) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-23-9-873 · Cited by 34 · see citing works

Measurement of aldosterone secretion rate in man by the use of a metabolite.

Cl, C., NICOLIS, G. L., & FRASER, B. (1961) · PubMed · Cited by 29 · see citing works

Endocrine factors

Wolff, H. P., Koczorek, K. R., Buchborn, E., & Rieker, G. (1959) · Journal of Chronic Diseases · doi:10.1016/0021-9681(59)90179-1 · Cited by 18 · see citing works

[Study of aldosteronuria in normal subjects and edematous cardiacs. I. Effect of varying intakes of sodium chloride].

Rs, M., MANNING, E. L., Af, M., & Am, R. (1956) · PubMed · Cited by 16 · see citing works

Studies of secretion and metabolism of aldosterone and cortisol.

Luetscher, J. A., Dowdy, A. J., CALLAGHAN, A. M., & Ap, C. (1962) · PubMed · Cited by 14 · see citing works

The relationship between urinary aldosterone, plasma volume, extracellular fluid volume and total body water.

Cox, J. R., SINGER, B., & Vérel, D. (1959) · PubMed · Cited by 11 · see citing works

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review

Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works

Primary Aldosteronism

Young, W. F., & Klee, G. G. (1988) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30425-0 · Cited by 192 · see citing works

Diabetic ketoacidosis in pregnancy

Kamalakannan, D., Baskar, V., Barton, D. M., & Abdu, T. A. M. (2003) · Postgraduate Medical Journal · doi:10.1136/pmj.79.934.454 · Cited by 148 · see citing works

Renin and angiotensin. A survey of some aspects

Brown, J. J., Lever, A. F., Davies, D. L., & Robertson, J. I. (1966) · Postgraduate Medical Journal · doi:10.1136/pgmj.42.485.153 · Cited by 115 · see citing works

The adrenal cortex in internal medicine. I.

Cope, C. L. (1966) · BMJ · doi:10.1136/bmj.2.5518.847 · Cited by 71 · see citing works

On the pathogenesis of metabolic alkalosis in hyperaldosteronism

Kassirer, J. P., London, A. M., Goldman, D. M., & Schwartz, W. B. (1970) · The American Journal of Medicine · doi:10.1016/s0002-9343(70)80021-3 · Cited by 69 · see citing works

Preoperative diagnosis of primary aldosteronism

Lauler, D. P. (1966) · The American Journal of Medicine · doi:10.1016/0002-9343(66)90045-3 · Cited by 65 · see citing works

Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients

GOMEZ-SANCHEZf, C. E., & HOLLAND, B. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-2-214 · Cited by 58 · see citing works

Decreased Plasma Clearance and Hepatic Extraction of Aldosterone in Patients with Heart Failure*

Camargo, C. A., Dowdy, A. J., Hancock, E. W., & Luetscher, J. A. (1965) · Journal of Clinical Investigation · doi:10.1172/jci105149 · Cited by 56 · see citing works

Maternal Toxicity of Drugs and Metabolic Disorders—A Possible Etiologic Factor in the Intrauterine Death and Congenital Malformation: A Critique on Human Data

Khera, K. S., & Hook, E. B. (1987) · Critical Reviews in Toxicology · doi:10.3109/10408448709029326 · Cited by 50 · see citing works

Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites

Girard, C., Barbier, O., Veilleux, G., El-Alfy, M., & Bélanger, A. (2003) · Endocrinology · doi:10.1210/en.2002-0052 · Cited by 45 · see citing works

Control of Aldosterone Secretion

Ganong, W. F., & Brunt, E. E. V. (1968) · Springer eBooks · doi:10.1007/978-3-642-99938-3_2 · Cited by 40 · see citing works

Aldosteron und Aldosteronismus

Wolff, H. P. (1964) · Journal of Molecular Medicine · doi:10.1007/bf01487806 · Cited by 39 · see citing works

The Effect of Administered ACTH on Aldosterone Metabolism and Secretion

Pratt, J. H., Dale, S. L., & Melby, J. C. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-2-355 · Cited by 33 · see citing works

Metabolism of Aldosterone in Several Experimental Situations with Altered Aldosterone Secretion*

Davis, J. O., Olichney, M. J., Brown, T. C., & Binnion, P. F. (1965) · Journal of Clinical Investigation · doi:10.1172/jci105249 · Cited by 29 · see citing works

Effects of acute, passive hepatic congestion on blood flow and oxygen uptake in the intact liver of the cat.

Lautt, W. W. (1977) · Circulation Research · doi:10.1161/01.res.41.6.787 · Cited by 26 · see citing works

Aldosterone and Angiotensin

Davis, J. O. (1964) · JAMA · doi:10.1001/jama.1964.03060380030008 · Cited by 20 · see citing works

ALDOSTERONE METABOLISM IN CARDIAC FAILURE

Hickie, J. B., & Lazarus, L. (1966) · Australasian Annals of Medicine · doi:10.1111/imj.1966.15.4.289 · Cited by 17 · see citing works

An Abbreviated History of Aldosterone Metabolism, Current and Future Challenges

Gómez-Sánchez, C. E., & Gómez-Sánchez, E. P. (2023) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-2054-1062 · Cited by 14 · see citing works

Recent Advances in Human Steroid Metabolism

HELLMAN, L., Bradlow, H. L., & Zumoff, B. (1970) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)60384-4 · Cited by 14 · see citing works

Enzymatic hydrolysis combined with chemiluminescence immunoassay: Foresight for automated and rapid urinary aldosterone detection

Zhong, J., Li, H., Yin, Y., Luo, W., Guo, X., Wang, D., Yu, S., & Qiu, L. (2025) · Analytica Chimica Acta · doi:10.1016/j.aca.2025.344403 · Cited by 6 · see citing works

Optimisation of total urinary aldosterone estimation: Comparison with other laboratory methods for assessment of mineralocorticoid status

Cunningham, S. K., Sequeira, S. J., Chambers, J., Heffernan, A., & McKenna, T. J. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90215-4 · Cited by 6 · see citing works

Primary Aldosteronism: Diagnosis and Treatment

Greenlee, H. B., Katz, F. H., & Sparagana, M. (1969) · Surgical Clinics of North America · doi:10.1016/s0039-6109(16)38737-0 · Cited by 5 · see citing works

Aldosteronism

Luetscher, J. A. (1964) · Disease-a-Month · doi:10.1016/s0011-5029(64)80003-1 · Cited by 4 · see citing works

Nutrition-Endocrine Relationships

Brown, J. N. (1964) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)33397-1 · Cited by 3 · see citing works

The metabolism of aldosterone and 3.ALPHA., 5.BETA.-tetrahydroaldosterone in the rabbit.

Miyazaki, T., & MIZUKOSHI, H. (1985) · Endocrinologia Japonica · doi:10.1507/endocrj1954.32.53 · Cited by 2 · see citing works

Vergleichende Untersuchungen zum diagnostischen Stellenwert der Urin-Steroide Aldosteron, Aldosteron-18-Glucuronid und Tetrahydro-Aldosteron in der Diagnostik des primären und sekundären Aldosteronismus

Abdelhamid, S., Thomas, L., Walb, D., Röckel, A., & Fiegel, P. (1992) · Journal of Laboratory Medicine · doi:10.1515/labm.1992.16.10.332

Neonatology Review : Infants of Diabetic Mothers

Leeuwen, G. V., & Jackson, R. L. (1965) · Clinical Pediatrics · doi:10.1177/000992286500400604

Dopaminergic Control of Aldosterone Secretion in Man

Suzuki, H., Kasai, K., Naitoh, T., Nakamura, T., Shiina, H., Ieiri, T., Takemura, Y., & Shimoda, S.-I. (1980) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.56.7_973

REFERENCES

(1971) · Elsevier eBooks · doi:10.1016/b978-0-08-013368-3.50014-5

The isolation of a urinary metabolite of aldosterone and its use to measure the rate of secretion of aldosterone by the adrenal cortex of man.

Ulick, S., Jh, L., & Lieberman, S. A. (1958) · PubMed · Cited by 107 · see citing works

Clinical Studies on the Secretion and Metabolism of Cortisol and Aldosterone

Yoshimi, T. (1965) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.41.1_51

Assay of Aldosterone and Metabolites

Tait, S. A. S., & Tait, J. F. (1962) · Elsevier eBooks · doi:10.1016/b978-1-4832-3033-7.50013-1 · Cited by 9 · see citing works

AN INVESTIGATION OF THE URINARY METABOLITES AND SECRETION RATES OF ALDOSTERONE AND CORTISOL IN MAN AND A DESCRIPTION OF METHODS FOR THEIR MEASUREMENT

Flood, C., Layne, D. S., Ramcharan, S., Rossipal, E., Tait, J. F., & Tait, S. A. S. (1961) · European Journal of Endocrinology · doi:10.1530/acta.0.0360237 · Cited by 114 · see citing works

Evaluation of adrenal function in rats by the measurement of urinary free corticosterone, free aldosterone and free 11-Deoxycorticosterone

Kley, H. K., Elsässer, W., Dehnen, H., & Krüskemper, H. L. (1978) · Steroids · doi:10.1016/0039-128x(78)90007-7 · Cited by 19 · see citing works