Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients

GOMEZ-SANCHEZf, CELSO E.; HOLLAND, BRYAN

doi:10.1210/jcem-52-2-214

Cited by 58Hormonal Regulation and HypertensionRenin-Angiotensin System StudiesAdrenal Hormones and Disorders

Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients

GOMEZ-SANCHEZf, CELSO E., HOLLAND, BRYAN·1981·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-52-2-214

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Abstract

Urinary aldosterone excretion is commonly determined by assay of aldosterone liberated from the acid-labile metabolite, aldosterone-18-glucuronide (Aldo-18-G), which reflects 5-15% of aldosterone secretion. However, since 3alpha, 5beta-tetrahydroaldosterone (TH-Aldo), the major metabolite, reflects 15-40% of aldosterone excretion, determination of its excretion should usually provide a more accurate index of aldosterone secretion. We have validated a RIA for urinary TH-Aldo and compared its excretion in black and white normal subjects and patients with essential hypertension and primary aldosteronism during consumption of low, normal, and high sodium diets. Urinary TH-Aldo excretion averaged 4.5 +/- 2.0 (mean +/- SD) times that of Aldo-18-G. The ratio of excretion of the two remained relatively constant during low, normal, and high sodium diets. There was no difference in the excretion of TH-Aldo or Aldo-18-G in black vs. white normal subjects or hypertensive patients and no age-related changes in the excretion of either metabolite from 20-60 yr of age. Two of nine patients with primary aldosteronism had normal Also-18-G excretion but elevated TH-Aldo excretion. We conclude that determination of both metabolites increases the diagnostic accuracy for primary aldosteronism.

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THAldo-glucuronides are consistently five-fold more prevalent than aldosterone-18β-glucuronide irrespective of sodium intake.
“THAldo-glucuronides are consistently five-fold more prevalent than aldosterone-18β-glucuronide irrespective of sodium intake [221].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [221]
Aldosterone-18β-glucuronide and THAldo-glucuronides contribute 5-15% and 15-40% towards the daily urinary excretion of aldosterone.
“aldosterone-18β-glucuronide and THAldo-glucuronides contribute 5–15% and 15–40% towards the daily urinary excretion of aldosterone [221,226].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [221]

A METHOD FOR PRODUCING SPECIFIC ANTISERA WITH SMALL DOSES OF IMMUNOGEN
Vaitukaitis, J. L., Robbins, J. B., Nieschlag, E., & ROSS, G. T. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-6-988 · Cited by 1,354 · see citing works
STEROID-PROTEIN CONJUGATES
Erlanger, B. F., Borek, F., Beiser, S. M., & Lieberman, S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70654-6 · Cited by 790 · see citing works
Reliability of screening methods for the diagnosis of primary aldosteronism
Streeten, D. H. P., Tomycz, N. D., & Anderson, G. H. (1979) · The American Journal of Medicine · doi:10.1016/0002-9343(79)90786-1 · Cited by 215 · see citing works
The Intravenous Furosemide Test: A Simple Way to Evaluate Renin Responsiveness
Kaplan, N. M., Kem, D. C., HOLLAND, O. B., Kramer, N. J., HIGGINS, J., & Gómez-Sánchez, C. E. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-6-639 · Cited by 141 · see citing works
Aldosterone Excretion: PHYSIOLOGICAL VARIATIONS IN MAN MEASURED BY RADIOIMMUNOASSAY OR DOUBLE-ISOTOPE DILUTION
Sealey, J. E., Bühler, F. R., Laragh, J. H., Manning, E. L., & Brunner, H. R. (1972) · Circulation Research · doi:10.1161/01.res.31.3.367 · Cited by 141 · see citing works
Racial differences in pressure, volume and renin interrelationships in essential hypertension.
Chrysant, S. G., Danisa, K., Kem, D. C., Dillard, B., Smith, W. J., & Frohlich, E. D. (1979) · Hypertension · doi:10.1161/01.hyp.1.2.136 · Cited by 131 · see citing works
AN INVESTIGATION OF THE URINARY METABOLITES AND SECRETION RATES OF ALDOSTERONE AND CORTISOL IN MAN AND A DESCRIPTION OF METHODS FOR THEIR MEASUREMENT
Flood, C., Layne, D. S., Ramcharan, S., Rossipal, E., Tait, J. F., & Tait, S. A. S. (1961) · European Journal of Endocrinology · doi:10.1530/acta.0.0360237 · Cited by 114 · see citing works
Urinary Kallikrein Excretion in Essential and Mineralocorticoid Hypertension
Holland, O. B., Chud, J. M., & Braunstein, H. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109678 · Cited by 108 · see citing works
The isolation of a urinary metabolite of aldosterone and its use to measure the rate of secretion of aldosterone by the adrenal cortex of man.
Ulick, S., Jh, L., & Lieberman, S. A. (1958) · PubMed · Cited by 107 · see citing works
A RADIOIMMUNOASSAY FOR PLASMA ALDOSTERONE BY IMMUNOLOGIC PURIFICATION
Gómez-Sánchez, C. E., Kern, D. C., & Kaplan, N. M. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-36-4-795 · Cited by 86 · see citing works
Racial Disparity of Plasma Volume in Hypertensive Man
LILLEY, J. J., HSU, L., & STONE, R. A. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-6-707 · Cited by 67 · see citing works
A Simple Radioimmunoassay for Urinary Aldosterone
Langan, J., JACKSON, R., Adlin, E. V., & Channick, B. J. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-2-189 · Cited by 61 · see citing works
ALDOSTERONE SECRETION IN SEVERE RENAL FAILURE.
Cl, C., & PEARSON, J. (1963) · PubMed · Cited by 48 · see citing works
Conjugation of 1,2-3H-Aldosterone in Human Liver and Kidneys and Renal Extraction of Aldosterone and Labeled Conjugates from Blood Plasma
Luetscher, J. A., Hancock, E. W., CAMARGO, C. A., Dowdy, A. J., & Nokes, G. W. (1965) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-25-5-628 · Cited by 43 · see citing works
ALDOSTERONE METABOLISM IN LIVER DISEASE
Hurter, R., & Nabarro, J. D. N. (1960) · European Journal of Endocrinology · doi:10.1530/acta.0.xxxiii0168 · Cited by 36 · see citing works
Observations on metabolism of aldosterone in man
LUETSCHER, J. A., CAMARGO, C. A., COHN, A. P., DOWDY, A. J., & CALLAGHAN, A. M. (1963) · Annals of Internal Medicine · doi:10.7326/0003-4819-59-1-1 · Cited by 30 · see citing works
Measurement of aldosterone secretion rate in man by the use of a metabolite.
Cl, C., NICOLIS, G. L., & FRASER, B. (1961) · PubMed · Cited by 29 · see citing works
RADIOIMMUNOASSAYS OF TETRAHYDROALDOSTERONE (TH-ALDO) IN HUMAN URINE
Kohl, K., Vecsei, P., & Abdelhamid, S. (1978) · European Journal of Endocrinology · doi:10.1530/acta.0.0870596 · Cited by 27 · see citing works
[45] Isolation and synthesis of the major metabolites of aldosterone and 18-hydroxycorticosterone
Ulick, S., & Ramirez, L. C. (1975) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(75)36048-5 · Cited by 21 · see citing works
Dissociation in the Excretion of Different Aldosterone Metabolites and Unmetabolized (‘Free’) Aldosterone in Hypertension
Abdelhamid, S., Vecsei, P., Haack, D., Gless, K.-H., Walb, D., LICHTWALD, K., & Fiegel, P. (1979) · Clinical Science · doi:10.1042/cs0570409 · Cited by 17 · see citing works
Simplification of urinary aldosterone measurement by radioimmunoassay
Cope, C. L., & Loizou, S. (1973) · Journal of Clinical Pathology · doi:10.1136/jcp.26.8.628 · Cited by 16 · see citing works
The effect of extremely high sodium intake on plasma renin activity, plasma aldosterone concentration, and urinary excretion of aldosterone metabolites.
Pratt, J. H., & Luft, F. C. (1979) · PubMed · Cited by 14 · see citing works
The measurement of urinary tetrahydroaldosterone by gas-liquid partition chromatography
Carr, H., & Wotiz, H. H. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)90997-1 · Cited by 8 · see citing works

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Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review
Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
“It has also been found that THAldo-glucuronides are consistently five-fold more prevalent than aldosterone-18β-glucuronide irrespective of sodium intake [221].”
Profiling steroid hormones and urinary steroids
Shackleton, C. H. L. (1986) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)80683-0 · Cited by 291 · see citing works
Further evaluation of saline infusion for the diagnosis of primary aldosteronism.
Holland, O. B., Brown, H., Kuhnert, L., Fairchild, C., Risk, M., & Gómez-Sánchez, C. E. (1984) · Hypertension · doi:10.1161/01.hyp.6.5.717 · Cited by 176 · see citing works
Racial Differences in Aldosterone Excretion and Plasma Aldosterone Concentrations in Children
Pratt, J. H., Jones, J. J., Miller, J. Z., Wagner, M. A., & Fineberg, N. S. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910263211703 · Cited by 135 · see citing works
Aging and aldosterone
Hegstad, R. L., Brown, R. D., Jiang, N., Kao, P. C., Weinshilboum, R. M., Strong, C. G., & Wisgerhof, M. V. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)90971-3 · Cited by 103 · see citing works
Laboratory challenges in primary aldosteronism screening and diagnosis
Rehan, M., Raizman, J. E., Cavalier, E., Don-Wauchope, A. C., & Holmes, D. T. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.01.003 · Cited by 89 · see citing works
Confirmatory testing in normokalaemic primary aldosteronism: the value of the saline infusion test and urinary aldosterone metabolites
Schirpenbach, C., Seiler, L., Maser‐Gluth, C., Rüdiger, F., Nickel, C. H., Beuschlein, F., & Reincke, M. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02164 · Cited by 66 · see citing works
Body Mass Index Predicts 24-Hour Urinary Aldosterone Levels in Patients With Resistant Hypertension
Dudenbostel, T., Ghazi, L., Liu, M., Li, P., Oparil, S., & Calhoun, D. A. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07806 · Cited by 58 · see citing works
Clinical Use of Laboratory Tests for the Identification of Secondary Forms of Arterial Hypertension
Rossi, G. P., Seccia, T. M., & Pessina, A. C. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360600931831 · Cited by 58 · see citing works
Urinary tetrahydroaldosterone as a screening method for primary aldosteronism: a comparative study
Abdelhamid, S. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(03)00858-6 · Cited by 57 · see citing works
Safety and efficacy of once-daily dexfadrostat phosphate in patients with primary aldosteronism: a randomised, parallel group, multicentre, phase 2 trial
Mulatero, P., Wuerzner, G., Groessl, M., Sconfienza, E., Damianaki, A., Forestiero, V., Vogt, B., Brunner, H. R., Gerlock, T. E., Steele, R., et al. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102576 · Cited by 54 · see citing works
Glucocorticoid-Suppressible Aldosteronism: A Disorder of the Adrenal Transitional Zone*
Gómez-Sánchez, C. E., Gill, J. R., Ganguly, A., & Gordon, R. D. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-444 · Cited by 46 · see citing works
Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites
Girard, C., Barbier, O., Veilleux, G., El-Alfy, M., & Bélanger, A. (2003) · Endocrinology · doi:10.1210/en.2002-0052 · Cited by 45 · see citing works
Racial Difference in the Activity of the Amiloride-Sensitive Epithelial Sodium Channel
Pratt, J. H., Ambrosius, W. T., Agarwal, R., Eckert, G. J., & Newman, S. A. (2002) · Hypertension · doi:10.1161/01.hyp.0000039749.75068.f4 · Cited by 43 · see citing works
Recalibrating Interpretations of Aldosterone Assays Across the Physiologic Range: Immunoassay and Liquid Chromatography–Tandem Mass Spectrometry Measurements Under Multiple Controlled Conditions
Brown, J. M., Auchus, R. J., Honzel, B., Luther, J. M., Yozamp, N. S., & Vaidya, A. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac049 · Cited by 41 · see citing works
The renin-angiotensin system in blacks: Active, passive, or what?
Price, D. A., & Fisher, N. D. L. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0025-x · Cited by 41 · see citing works
The cynomolgus monkey (Macaca fascicularis) is the best animal model for the study of steroid glucuronidation
Barbier, O., & Bélanger, A. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00235-8 · Cited by 39 · see citing works
Aldosterone metabolites and possible aldosterone precursors in hypertension
Vecsei, P., Abdelhamid, S., Mittelstadt, G. V., LICHTWALD, K., Haack, D., & Lewicka, S. (1983) · Journal of Steroid Biochemistry · doi:10.1016/s0022-4731(83)80046-6 · Cited by 36 · see citing works
Alterations in Aldosterone Secretion and Metabolism in Low Renin Hypertension*
Griffing, G. T., WILSON, T. E., & Melby, J. C. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1454 · Cited by 30 · see citing works
Comparison of 24-h Urinary Aldosterone Level and Random Urinary Aldosterone-to-Creatinine Ratio in the Diagnosis of Primary Aldosteronism
Wu, C., Yang, Y., Hu, Y., Tsai, Y., Kuo, K.-L., Lin, Y., Hung, S., Wu, V., Wu, K., & the Taiwan Primary Aldosteronism Investigation (TAIPAI) Study Group (2013) · PLoS ONE · doi:10.1371/journal.pone.0067417 · Cited by 29 · see citing works
Characterizing the Origins of Primary Aldosteronism
Brown, J. M., Honzel, B., Tsai, L. C., Milks, J., Neibuhr, Y., Newman, A. J., Cherney, M. D., Stouffer, D. G., Auchus, R. J., & Vaidya, A. (2024) · Hypertension · doi:10.1161/hypertensionaha.124.24153 · Cited by 30 · see citing works
Urinary 18-Hydroxy cortisol and Its Relationship to the Excretion of Other Adrenal Steroids*
Gómez-Sánchez, C. E., UPCAVAGE, R. J., Zager, P. G., Foecking, M. F., Holland, O. B., & Ganguly, A. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-2-310 · Cited by 28 · see citing works
Primary aldosteronism and its variants
Gómez-Sánchez, C. E. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00230-7 · Cited by 25 · see citing works
Screening for primary aldosteronism
Schirpenbach, C., & Reincke, M. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.07.007 · Cited by 23 · see citing works
Adrenal venous sampling for primary aldosteronism: laboratory medicine best practice
Kline, G. A., & Holmes, D. T. (2017) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2017-204423 · Cited by 22 · see citing works
The involvement of the renin-angiotensin-aldosterone system, the corticotropin-glucocorticoid system, antidiuretic hormone, catecholamines and prostaglandins
Marin-Grez, M. (1982) · Biochemical Pharmacology · doi:10.1016/0006-2952(82)90639-6 · Cited by 18 · see citing works
Effect of Chronic Adrenocorticotropin Stimulation on the Excretion of 18-Hydroxycortisol and 18-Oxocortisol*
Gómez-Sánchez, C. E., Clore, J. N., Estep, H. L., & Watlington, C. O. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-2-322 · Cited by 19 · see citing works
High-performance liquid chromatographic determination of 3α,5β- tetrahydroaldosterone in human urine with chemiluminescence detection
Ishida, J., Sonezaki, S., Yamaguchi, M., & Yoshitake, T. (1992) · The Analyst · doi:10.1039/an9921701719 · Cited by 17 · see citing works
Role of 18-hydroxylated cortisols in hypertension
Gómez-Sánchez, C. E., Gómez-Sánchez, E. P., & Holland, O. B. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90176-2 · Cited by 16 · see citing works
Are There Beta-Adrenergic Receptor Response Differences between Racial Groups?
Rutledge, D. R. (1991) · DICP · doi:10.1177/106002809102500719 · Cited by 15 · see citing works
An Abbreviated History of Aldosterone Metabolism, Current and Future Challenges
Gómez-Sánchez, C. E., & Gómez-Sánchez, E. P. (2023) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-2054-1062 · Cited by 14 · see citing works
Urinary Free 19–Nor–Deoxycorticosterone and Deoxycorticosterone in Human Hypertension*
Gómez-Sánchez, C. E., Holland, O. B., & UPCAVAGE, R. J. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-2-234 · Cited by 13 · see citing works
18-Oxocortisol: Effect of dexamethasone, ACTH and sodium restriction
Gómez-Sánchez, C. E., Zager, P. G., Foecking, M. F., Holland, O. B., & Ganguly, A. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90214-8 · Cited by 12 · see citing works
A LC-MS/MS method for the simultaneous quantitative determination of aldosterone, its precursor 18-hydroxycorticosterone and its metabolite tetrahydroaldosterone in human urine
Dong, H., Hu, B., Chen, W., Wang, L., Sun, H., Zhou, J., Chen, B., Chen, B., & Du, Z. (2024) · Journal of Chromatography B · doi:10.1016/j.jchromb.2024.124012 · Cited by 10 · see citing works
High performance liquid chromatographic determination of 3α, 5β‐tetrahydroaldosterone and cortisol in human urine with fluorescence detection
Yoshitake, T., Ishida, J., Sonezaki, S., & Yamaguchi, M. (1992) · Biomedical Chromatography · doi:10.1002/bmc.1130060502 · Cited by 9 · see citing works
CLINICAL SIGNIFICANCE OF UNCONJUGATED 3α,5β‐TETRAHYDROALDOSTERONE AND 5β‐DIHYDROALDOSTERONE MEASURED BY RADIOIMMUNOASSAY
Lewicka, S., & Vecsei, P. (1985) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1985.tb01074.x · Cited by 8 · see citing works
Racial Differences in Drug Response: Isoproterenol Effects Before and After Propranolol
Rutledge, D. R., Wallace, A., Steinberg, J. D., Cardozo, L. J., & Lavine, S. J. (1991) · Pharmaceutical Research · doi:10.1023/a:1015806202180 · Cited by 8 · see citing works
Altered Fractional Tetrahydroaldosterone Excretion during Pharmacological Blockade and Activation of the Renin-Aldosterone System*
Griffing, G. T., WILSON, T. E., & Melby, J. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-6-1217 · Cited by 7 · see citing works
Enzymatic hydrolysis combined with chemiluminescence immunoassay: Foresight for automated and rapid urinary aldosterone detection
Zhong, J., Li, H., Yin, Y., Luo, W., Guo, X., Wang, D., Yu, S., & Qiu, L. (2025) · Analytica Chimica Acta · doi:10.1016/j.aca.2025.344403 · Cited by 6 · see citing works
Optimisation of total urinary aldosterone estimation: Comparison with other laboratory methods for assessment of mineralocorticoid status
Cunningham, S. K., Sequeira, S. J., Chambers, J., Heffernan, A., & McKenna, T. J. (1988) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(88)90215-4 · Cited by 6 · see citing works
Radioimmunoassay of urinary 21-deoxytetrahydroaldosterone in primary aldosteronism and 21-hydroxylase deficiency
Lewicka, S., Winter, J., Bokkenheuser, V. D., Vecsei, P., Abdelhamid, S., & Heinrich, U. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90123-8 · Cited by 6 · see citing works
Estimation of urinary aldosterone using thin-layer chromatography and fluorimetry.
Mattingly, D., Martin, H., & Tyler, C. J. (1993) · Journal of Clinical Pathology · doi:10.1136/jcp.46.12.1109 · Cited by 5 · see citing works
HPLC isolation and GC-MS characterization of a compound strongly cross reacting with tetrahydroaldosterone antiserum
Fisher, T., Vecsei, P., HOYER, G. ‐., LICHTWALD, K., & KIRK, D. N. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90283-9 · Cited by 5 · see citing works
Rapid chromatographic purification of urinary steroid glucuronates for determination of aldosterone secretion rate
Risk, M., Holland, O. B., & Brown, H. (1984) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)91676-0 · Cited by 4 · see citing works
The association of infant urinary adrenal steroids with the risk of childhood asthma development
Turi, K. N., Li, Y., Xu, Y., Gebretsadik, T. S., Rosas‐Salazar, C., Wiggins, D. A., McKennan, C. G., Newcomb, D. C., Gern, J. E., & Hartert, T. V. (2024) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2024.04.008 · Cited by 4 · see citing works
Simultaneous quantitation of urine aldosterone and tetrahydroaldosterone in healthy Chinese subjects using a validated LC–MS/MS method
Cheng, J. Y. K., Lo, C. W. S., Chan, A. S.-L., Luk, Y. K., Tsui, T. K. C., & Ho, C. S. (2023) · Biomedical Chromatography · doi:10.1002/bmc.5694 · Cited by 3 · see citing works
Adrenocorticosteroid excretion in salt-sensitive and salt-resistant spontaneously hypertensive rats
Griffing, G. T., Melby, J. C., Holbrook, M., Wilson, T. C., & Wyss, J. M. (1992) · Steroids · doi:10.1016/0039-128x(92)90036-9 · Cited by 3 · see citing works
Role of 21-deoxyaldosterone in human hypertension
Abdelhamid, S., Lewicka, S., Bige, K., Haack, D., Lorenz, H., Nensel, U., Röckel, A., Fiegel, P., Walb, D., & Vecsei, P. (1994) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(94)90138-4 · Cited by 3 · see citing works
Diagnostic Accuracy of 24‐Hour Urinary Aldosterone for Primary Aldosteronism in Northeast China
Sun, K., Gong, M., Yu, Y., Yang, M., Jiang, Y., Zhang, Y., & Song, W. (2025) · Journal of Clinical Hypertension · doi:10.1111/jch.70130 · Cited by 2 · see citing works
Unmasking primary aldosteronism: Transforming disease management with advanced steroid profiling
Zhong, J., Paljor, T., Yu, S., & Qiu, L. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120186 · Cited by 2 · see citing works
Urinary aldosterone and tetrahydroaldosterone by LC-MS/MS with enzymatic hydrolysis: validation and age-stratified reference intervals
der Kooi, I. W.-V., van Faassen, M. H. J. R., Kerstens, M., Kema, I. P., & Vos, M. J. (2026) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2025-1679 · Cited by 1 · see citing works
Determination of aldosterone secretion rate utilizing mixed mode and high performance liquid chromatography
Holland, O. B., Risk, M., Brown, H., Benedict, C. R., & Hammond, G. S. (1986) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(86)90404-8 · Cited by 1 · see citing works
ALDOSTERONE METABOLITES AND POSSIBLE ALDOSTERONE PRECURSORS IN HYPERTENSION
Vecsei, P., Abdelhamid, S., Mittelstadt, G. V., LICHTWALD, K., Haack, D., & Lewicka, S. (1983) · Elsevier eBooks · doi:10.1016/b978-0-08-030771-8.50049-8 · Cited by 1 · see citing works
Mineralocorticoid Biosynthetic Pathways and Hypertension
Gómez-Sánchez, C. E. (1998) · Endocrine updates · doi:10.1007/978-1-4615-5569-8_16
Solid Phase Radioimmunoassay for the Determination of Aldosterone Excretion
Török, A. (1993) · Journal of Immunoassay · doi:10.1080/15321819308019856
Untersuchungen zum diagnostischen Stellenwert der Aldosteron-Vorstufe 18-Hydroxycorticosteron in der Diagnose und Differentialdiagnose des primären Hyperaldosteronismus
Abdelhamid, S., Thomas, L., Nensel, U., Lorenz, H., Röckel, A., Bönhof, J., & Müller-Lobeck, H. (1994) · Journal of Laboratory Medicine · doi:10.1515/labm.1994.18.6.275
Steroids in urine, other fluids and tissues
Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00007-3
The Renin—Angiotensin—Aldosterone System and Atrial Natriuretic Factor
Atlas, S. A., Sealey, J. E., & Laragh, J. H. (1989) · Springer eBooks · doi:10.1007/978-1-4899-0906-0_15

Dissociation in the Excretion of Different Aldosterone Metabolites and Unmetabolized (‘Free’) Aldosterone in Hypertension
Abdelhamid, S., Vecsei, P., Haack, D., Gless, K.-H., Walb, D., LICHTWALD, K., & Fiegel, P. (1979) · Clinical Science · doi:10.1042/cs0570409 · Cited by 17 · see citing works
Aldosterone metabolites and possible aldosterone precursors in hypertension
Vecsei, P., Abdelhamid, S., Mittelstadt, G. V., LICHTWALD, K., Haack, D., & Lewicka, S. (1983) · Journal of Steroid Biochemistry · doi:10.1016/s0022-4731(83)80046-6 · Cited by 36 · see citing works
Determination of Urinary 3α, 5β-tetrahydroaldosterone as a Parameter of Aldosterone Secretion in Hypertensive Patients
Shunichi, H. A. T. A. (1981) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.57.1_89
Isolation of aldosterone urinary metabolites, glucuronides and sulfate
Grose, J. H., Nowaczynski, W. J., Kuchel, O., & Genest, J. (1973) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(73)90030-7 · Cited by 17 · see citing works
21-Deoxytetrahydroaldosterone Excretion in Primary Hyperaldosteronism
Abdelhamid, S., Lewick, S., Vecsei, P., & Winter, J. (2008) · Cardiology · doi:10.1159/000173954 · Cited by 1 · see citing works

Authors: GOMEZ-SANCHEZf, C. E., & HOLLAND, B.
Affiliations: University of South Florida (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1981-02
Volume: 52
Issue: 2
Pages: 214-219
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-52-2-214
OpenAlex: W2150331207
Cited by: 58
References: 23
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1
FWCI: 2.98
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hl026856-06)
National Center for Research Resources (M01RR000633)
NIH Clinical Center
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: aldosterone excretion, primary aldosteronism, essential hypertension, sodium intake, racial differences, age-related changes, radioimmunoassay validation, diagnostic accuracy
MeSH terms: Adult, Aldosterone, Diet, Female, Glucuronates, Humans, Hyperaldosteronism, Hypertension, Kinetics, Male, Middle Aged, Radioimmunoassay, Sodium, Black People, White People

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Urinary tetrahydroaldosterone and aldosterone-18-glucuronide excretion in white and black normal subjects and hypertensive patients

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