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Cited by 2,057

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease: The Framingham Study

KANNEL, WILLIAM B., CASTELLI, WILLIAM P., GORDON, TAVIA, MCNAMARA, PATRICIA M.·1971·Annals of Internal Medicine

Abstract

Risk of coronary heart disease over 14 years was examined prospectively in 2,282 men and 2,845 women according to their antecedent cholesterol and lipoprotein status. An increased risk proportional to antecedent serum cholesterol was found whether or not it was associated with elevated Sf20-400 prebeta lipoprotein. When adjustment was made for the concomitant prebeta lipoprotein concentration and other factors related both to coronary heart disease risk and to blood lipids, a residual gradient of coronary heart disease risk proportional to the serum cholesterol was still evident. On the other hand, when risk of coronary heart disease was examined according to prebeta lipoprotein concentration, adjusting for cholesterol, no residual risk gradient remained in men. In women over 50, however, prebeta lipoprotein was superior to cholesterol in discriminating potential coronary heart disease cases. Risk of coronary heart disease in men can be estimated using any of the lipids evaluated: however, none proved more useful than an accurate total serum cholesterol.

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Metadata

Authors
KANNEL, W. B., CASTELLI, W. P., GORDON, T., & MCNAMARA, P. M.
Venue
Annals of Internal Medicine
Published
1971-01-01
Volume
74
Issue
1
Pages
1-12
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
OpenAlex
W2112698709
Cited by
2,057
References
1
FWCI
82.43
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease: The Framingham Study. https://app.cochat.ai/papers/10.7326/0003-4819-74-1-1
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KANNEL, W. B., CASTELLI, W. P., GORDON, T., & MCNAMARA, P. M. (1971). Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease: The Framingham Study. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-74-1-1

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.