Circadian variation of the serum thyrotropin level in normal subjects

Weeke, J.

doi:10.3109/00365517309082440

Cited by 117Thyroid Disorders and TreatmentsCircadian rhythm and melatoninClinical Laboratory Practices and Quality Control

Circadian variation of the serum thyrotropin level in normal subjects

Weeke, J.·1973·Scandinavian Journal of Clinical and Laboratory Investigation

DOI 10.3109/00365517309082440

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Abstract

A circadian rhythm of serum thyrotropin (TSH) has been demonstrated by measurements performed on half-hourly blood samples collected over a 24-hour period from 8 healthy young men and 5 healthy young women. The serum TSH level decreased from 8 a.m. to 11 a.m. There was a low level during the day-time with a mean serum TSH value of 0.85 μU/ml. The level increased in the evening between 8 p.m. and 11 p.m., and a higher TSH level was maintained during the night, with a mean value of 1.34 Ü/ml. The difference between day and night level was highly significant. There was no relation between the meals and the variation of the TSH level. The rise of serum TSH preceded the onset of sleep. The circadian rhythm of serum TSH is not only of physiological interest but has also the practical consequence that blood sample collection for TSH determinations is best performed at 11 a.m., when the TSH level has fallen to the day-time level.

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The suprachiasmatic nucleus is involved in regulation of the circadian TSH rhythm.
“The suprachiasmatic nucleus, which is considered to be the principal circadian pacemaker of the brain, is involved in the regulation of the circadian TSH rhythm (Mariotti and Beck-Peccoz, 2016;Weeke, 1973).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Weeke, 1973
TSH has a circadian rhythm with highest levels between 02:00-04:00 h and lowest between 16:00-20:00 h.
“However, TSH has a circadian rhythm with the highest and lowest levels between 02:00-04:00 h and 16:00-20:00H, respectively (Mariotti and Beck-Peccoz, 2016;Weeke, 1973).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Weeke, 1973

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Authors: Weeke, J.
Affiliations: Aarhus Municipality (DK)
Corresponding author: Weeke, J.
Venue: Scandinavian Journal of Clinical and Laboratory Investigation
Publisher: Informa UK Limited
Published: 1973-01
Volume: 31
Issue: 3
Pages: 337-342
ISSN: 0036-5513 (ISSN-L)
1502-7686
DOI: 10.3109/00365517309082440
OpenAlex: W2028796360
Cited by: 117
References: 22
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 1
FWCI: 6.65
Type: journal article
Language: en
Open access: closed
Locations: Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
Keywords: thyroid-stimulating hormone, circadian rhythm, serum TSH, diurnal variation, sleep onset, blood sampling timing, healthy volunteers
MeSH terms: Adult, Animals, Buffers, Cattle, Chloramines, Chromatography, Gel, Chromatography, Paper, Circadian Rhythm, Female, Humans, Immune Sera, Iodine Radioisotopes, Isotope Labeling, Male, Mercury, Methods, Organometallic Compounds, Rabbits, Radioimmunoassay, Serum Albumin, Bovine, Sulfites, Thyrotropin, Time Factors

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Circadian variation of the serum thyrotropin level in normal subjects

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