The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Estrogen-Androgen Imbalance in Hepatic Cirrhosis: Studies in 13 Male Patients
Abstract
Serum concentrations of testosterone, dihydrotestosterone, estradiol-17β (E2), and gonadotrophins were studied in 13 male patients with hepatic cirrhosis. The mean serum total and unbound testosterone concentrations were significantly lower in the cirrhotic patients than in normal men. Serum dihydrotestosterone levels were also subnormal in five of six patients studied. On the other hand, the mean serum total and unbound E2 concentrations were significantly higher in patients with cirrhosis than in normal men. The most consistent abnormality and the one uniformly present was a supranormal E2 to testosterone ratio, as calculated from serum concentration of total or unbound steroids. These findings suggest that changes in the relative balance between circulating estrogen and androgen may play some part in the pathogenesis of gynecomastia in hepatic cirrhosis. The mean serum luteinizing hormone concentration was elevated in patients with cirrhosis, whereas that of follicle-stimulating hormone did not differ from normal.
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Cites
Effects of Induced Hyperthyroidism on Steroid Metabolism in Man
RUDER, H., CORVOL, P., MAHOUDEAU, J. A., ROSS, G. T., & LIPSETT, M. B. (1971) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-33-3-382 · Cited by 139
Cited by
Effect of Alcohol (Ethanol) Administration on Sex-Hormone Metabolism in Normal Men
Gordon, G. G., Altman, K., Southren, A. L., Rubin, E., & Lieber, C. S. (1976) · New England Journal of Medicine · doi:10.1056/nejm197610072951501 · Cited by 364
Sex hormones and coronary disease: a review of the clinical studies
Kalin, M. F., & Zumoff, B. (1990) · Steroids · doi:10.1016/0039-128x(90)90058-j · Cited by 271
Effects of Acute Alcohol Administration on Reproductive Endocrinology in the Male Rat
Cicero, T. J., Bernstein, D., & Badger, T. M. (1978) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1978.tb05807.x · Cited by 82
Metadata
- Authors
- CHOPRA, I. J., TULCHINSKY, D., & GREENWAY, F. L.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1973-08-01
- Volume
- 79
- Issue
- 2
- Pages
- 198-203
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1993308904
- Cited by
- 176
- References
- 1
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CHOPRA, I. J., TULCHINSKY, D., & GREENWAY, F. L. (1973). Estrogen-Androgen Imbalance in Hepatic Cirrhosis: Studies in 13 Male Patients. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-79-2-198
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
