Effects of Induced Hyperthyroidism on Steroid Metabolism in Man
Abstract
Five normal men were made clinically hyperthyroid by administration of T3, 300 μg daily for three weeks. In 3 men, estradiol metabolic clearance rates and plasma concentration of testosterone-estradiol binding globulin (TeBG) were measured during the control periods, during fluoxymesterone administration, and during hyperthyroidism. Plasma LH and testosterone concentrations were determined throughout all studies in 5 men. Treatment with T3 caused a 7–8 fold increase in TeBG; a 2–3 fold increase in plasma testosterone; no change in CBG, and no change in in 2 patients and a 25% decrease in the third. The marked rise in TeBG during T3 treatment was not accompanied by a corresponding large fall in hence it is most likely that hyperthyroidism increased the rate of metabolism of estradiol. In spite of a 2–3 fold increase in plasma testosterone, plasma LH increased during T3 treatment, indicating that it is the non-TeBG-bound testosterone that determines LH release. The plasma half-life of TeBG was esti...
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Thyrotoxicosis is featured by an increase in SHBG as well as increased total T concentrations.
“Thyrotoxicosis is also featured by an increase in SHBG as well as increased total T concentrations [97].”
From Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology (2022) · cites this paper as [97]
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- Authors
- RUDER, H., CORVOL, P., MAHOUDEAU, J. A., ROSS, G. T., & LIPSETT, M. B.
- Affiliations
- National Institutes of Health (US)
- ORCID
- LIPSETT, M. B.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1971-09
- Volume
- 33
- Issue
- 3
- Pages
- 382-387
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2045767288
- Cited by
- 139
- References
- 0
- Citations by year
- 2025: 1 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2013: 2 · 2012: 4
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- triiodothyronine, steroid metabolism, estradiol, testosterone, sex hormone-binding globulin, luteinizing hormone, LH release, plasma testosterone
- MeSH terms
- Adult, Beta-Globulins, Chromatography, Chromatography, Thin Layer, Estradiol, Estrone, Fluoxymesterone, Half-Life, Humans, Hyperthyroidism, Hypothalamo-Hypophyseal System, Luteinizing Hormone, Male, Metabolic Clearance Rate, Testosterone, Triiodothyronine, Tritium
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