The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hypopituitarism After External Irradiation: Evidence for Both Hypothalamic and Pituitary Origin
Abstract
Endocrine complications after radiotherapy for tumors of the head and neck are thought to be relatively rare. The availability of synthetic hypothalamic hormones for clinical investigations and the radioimmunoassay of hormones have enabled us to study function of the hypothalamic pituitary axis in 15 patients who had radiotherapy for nasopharyngeal cancer. Fourteen had evidence of endocrine deficiency. Twelve patients had evidence of hypothalamic dysfunction, 7 developed primary pituitary hormone deficiencies, and 3 developed primary hypothyroidism. These results indicate that [1] secondary hypopituitarism due to a hypothalamic lesion after radiotherapy for nasopharyngeal cancer may be more common than suspected in the past; [2] primary hypopituitarism after irradiation of extracranial tumors can occur; and [3[ primary hypothyroidism may result from irradiation of regional neck nodes.
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Citations
Cites
A Radioimmunoassay for Human Prolactin
Hwang, P., Guyda, H., & Friesen, H. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.8.1902 · Cited by 752
Landon, J., Greenwood, F. C., Stamp, T. C., & Wynn, V (1966) · Journal of Clinical Investigation · doi:10.1172/jci105358 · Cited by 262
Cited by
Darzy, K. H., Aimaretti, G., Wieringa, G., Gattamaneni, H. R., Ghigo, E., & Shalet, S. M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021094 · Cited by 182
Hypopituitarism following radiation therapy of pituitary adenomas
Snyder, P. J., Fowble, B. F., Schatz, N. J., Savino, P. J., & Gennarelli, T. A. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90299-8 · Cited by 167
Appelman-Dijkstra, N. M., Kokshoorn, N. E., Dekkers, O. M., Neelis, K. J., Biermasz, N. R., Romijn, J. A., Smit, J. W. A., & Pereira, A. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0306 · Cited by 162
Endocrine and neurophysiologic responses of the pituitary to insulin-induced hypoglycemia: A review
Fish, H. R., Chernow, B., & O'Brian, J. T. (1986) · Metabolism · doi:10.1016/0026-0495(86)90245-3 · Cited by 117
Romshe, C. A., Zipf, W. B., Miser, A., Miser, J., Sotos, J. F., & Newton, W. A. (1984) · The Journal of Pediatrics · doi:10.1016/s0022-3476(84)80988-9 · Cited by 96
Metadata
- Authors
- SAMAAN, N. A., BAKDASH, M. M., CADERAO, J. B., CANGIR, A., JESSE, R. H., & BALLANTYNE, A. J.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1975-12-01
- Volume
- 83
- Issue
- 6
- Pages
- 771-777
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W1979911737
- Cited by
- 168
- References
- 2
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hypopituitarism After External Irradiation: Evidence for Both Hypothalamic and Pituitary Origin. https://app.cochat.ai/papers/10.7326/0003-4819-83-6-771
- The paper
- SAMAAN, N. A., BAKDASH, M. M., CADERAO, J. B., CANGIR, A., JESSE, R. H., & BALLANTYNE, A. J. (1975). Hypopituitarism After External Irradiation: Evidence for Both Hypothalamic and Pituitary Origin. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-83-6-771
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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