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Treatment of Invasive Aspergillosis: Relation of Early Diagnosis and Treatment to Response
Abstract
Aspergillus infections in patients with cancer are difficult to diagnose, and such diagnoses are frequently made at necropsy. Earlier therapy has been proposed to provide better response. We reviewed 17 consecutive patients with documented aspergillosis to determine the impact of earlier diagnosis and prompt treatment with amphotericin B. Sixteen had hematologic malignancies, and all had marked granulocytopenia. Six were diagnosed and treated within 96 h of the appearance of infiltrates. Three of these six had complete resolution of all signs and symptoms of aspergillus infection. The other three had a partial response to therapy despite continued granulocytopenia. All 11 patients in whom antifungal therapy was either delayed (six) or not given (five) for at least 2 weeks after the infiltrate was present diet with progressive aspergillosis aggressive diagnostic methods to establish the diagnosis of aspergillosis are warranted so that antifungal therapy can be started early, which may then be successful in resolving these potentially fatal infections.
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Cited by
Pizzo, P. A., Robichaud, K. J., Gill, F. A., & Witebsky, F. G. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90594-0 · Cited by 859
Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis
Denning, D. W., Ribaud, P., Milpied, N., Caillot, D., Herbrecht, R., Thiel, E., Haas, A., Ruhnke, M., & Lode, H. (2002) · Clinical Infectious Diseases · doi:10.1086/324620 · Cited by 844
Invasive Aspergillosis: Epidemiology, Diagnosis and Management in Immunocompromised Patients
Maschmeyer, G., Haas, A., & Cornely, O. A. (2007) · Drugs · doi:10.2165/00003495-200767110-00004 · Cited by 366
Segal, B. H., Almyroudis, N. G., Battiwalla, M., Herbrecht, R., Perfect, J. R., Walsh, T. J., & Wingard, J. R. (2007) · Clinical Infectious Diseases · doi:10.1086/510677 · Cited by 168
Viscoli, C., Castagnola, E., Van Lint, M. T., Moroni, C., Garaventa, A., Rossi, M. R., Fanci, R., Menichetti, F., Caselli, D., Giacchino, M., et al. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(95)00619-2 · Cited by 122
Metadata
- Authors
- AISNER, J., SCHIMPFF, S. C., & WIERNIK, P. H.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1977-05-01
- Volume
- 86
- Issue
- 5
- Pages
- 539-543
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2025804022
- Cited by
- 397
- References
- 0
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- AISNER, J., SCHIMPFF, S. C., & WIERNIK, P. H. (1977). Treatment of Invasive Aspergillosis: Relation of Early Diagnosis and Treatment to Response. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-86-5-539
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
