Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia
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Neutropenic patients with persistent fever despite broad-spectrum antimicrobial therapy have an approximately 20% risk of developing an overt invasive fungal infection.
“Randomized, prospective clinical trials have demonstrated that neutropenic patients with persistent fever despite receipt of broad-spectrum antimicrobial therapy have an ∼20% risk of developing an overt invasive fungal infection [148, 149].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [148]
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- Authors
- Pizzo, P. A., Robichaud, K. J., Gill, F. A., & Witebsky, F. G.
- Corresponding author
- Pizzo, Philip A.
- ORCID
- Pizzo, Philip A.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1982-01
- Volume
- 72
- Issue
- 1
- Pages
- 101-111
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2114208000
- Cited by
- 859
- References
- 27
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 11 · 2016: 12 · 2015: 7 · 2014: 22 · 2013: 24 · 2012: 26
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- empirical antibiotic therapy, empirical antifungal therapy, persistent fever, granulocytopenia, cancer patients, disseminated fungal infection, amphotericin B, gentamicin, carbenicillin, fungal colonization, opportunistic infections, febrile neutropenia, infection incidence, shock
- MeSH terms
- Adolescent, Adult, Agranulocytosis, Amphotericin B, Anti-Bacterial Agents, Antifungal Agents, Bacterial Infections, Carbenicillin, Cephalothin, Child, Child, Preschool, Drug Therapy, Combination, Fever of Unknown Origin, Gentamicins, Humans, Mycoses, Neoplasms, Prospective Studies, Random Allocation
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