Malabsorption of Thyroid Hormones After Jejunoileal Bypass for Obesity
Abstract
Brief Reports1 June 1979Malabsorption of Thyroid Hormones After Jejunoileal Bypass for ObesityFEREIDOUN AZIZI, M.D., ROY BELUR, M.S., JOSEPHINE ALBANO, M.D.FEREIDOUN AZIZI, M.D., ROY BELUR, M.S., JOSEPHINE ALBANO, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-941 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe malabsorption state caused by small intestinal bypass surgery may result in nutritional deficiencies. The drastic loss of jejunum and ileum interferes with normal absorption of various substances, leading to metabolic derangement, vitamin deficiencies, and even nutritional cirrhosis of the liver (1). We have recently seen a patient with hypothyroidism and obesity who developed severe malabsorption of thyroid hormones after a bypass operation.A 38-year-old white woman was referred for evaluation of hypothyroidism in March 1977. 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Author, Article, and Disclosure InformationAffiliations: St. Elizabeth's Hospital and Tufts University School of Medicine Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvaluation of Thyroid Hormone Replacement Dosing in Morbidly Obese Hypothyroid Patients after Bariatric Surgery-Induced Weight LossChanges of Drug Pharmacokinetics in Patients with Short Bowel Syndrome: A Systematic ReviewHypothyroidism and levothyroxine therapy following bariatric surgery: a systematic review, meta-analysis, network meta-analysis, and meta-regressionLevothyroxine dose adjustment in hypothyroid patients following gastric sleeve surgeryOral levothyroxine therapy postbariatric surgery: Biopharmaceutical aspects and clinical effectsGastrointestinal Malabsorption of ThyroxineThe Effect of the Bariatric Surgery Type on the Levothyroxine Dose of Morbidly Obese Hypothyroid PatientsLevothyroxine pseudo-malabsorption: testing and treatment in the outpatient settingAdvancements in the treatment of hypothyroidism with L-T4 liquid formulation or soft gel capsule: an updateTSH Normalization in Bariatric Surgery Patients After the Switch from l-Thyroxine in Tablet to an Oral Liquid FormulationLevothyroxine Dosing Following Bariatric SurgeryObese Patients with Hypothyroidism May Require Lower Doses of Levothyroxine After Bariatric SurgeryWeight Loss and Variation of Levothyroxine Requirements in Hypothyroid Obese Patients After Bariatric SurgeryRapid Levothyroxine Absorption Testing: A Case Series of Nonadherent PatientsGuidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone ReplacementTreatment With Thyroid HormoneA Benefit–Risk Assessment of the Use of Proton Pump Inhibitors in the ElderlyOral Liquid l-Thyroxine (l-T4) May Be Better Absorbed Compared to l-T4 Tablets Following Bariatric SurgeryThe Influence of Bypass Procedures and Other Anatomical Changes in the Gastrointestinal Tract on the Oral Bioavailability of DrugsImproved Levothyroxine Pharmacokinetics After Bariatric SurgeryTrends in oral drug bioavailability following bariatric surgery: exa
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Although case reports suggest increased LT4 requirements after intestinal bypass surgery, direct study showed LT4 absorption appeared preserved after Roux-en-Y surgery and in 32 patients undergoing other gastric bypass procedures.
“Although there are case reports of increased LT4 requirements after intestinal bypass surgery (164-166), when studied directly LT4 absorption appeared to be preserved after Roux-en-Y surgery (167) and in 32 patients undergoing various other gastric bypass procedures (168).”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [164]
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Effect of bariatric surgery on TSH levels and levothyroxine dosage in patients with thyroid diseasePreprint
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- Authors
- AZIZI, F., BELUR, R., & ALBANO, J.
- Affiliations
- Tufts University (US)
- Corresponding author
- AZIZI, FEREIDOUN
- ORCID
- AZIZI, FEREIDOUN
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1979-06-01
- Volume
- 90
- Issue
- 6
- Pages
- 941-942
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2015093529
- Cited by
- 61
- References
- 12
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- jejunoileal bypass, morbid obesity, hypothyroidism, nutritional deficiency, thyroid hormone absorption, thyroid-stimulating hormone, postoperative complications, bariatric surgery complications, vitamin deficiency, liver cirrhosis
- MeSH terms
- Adult, Biological Transport, Female, Humans, Ileum, Intestinal Absorption, Jejunum, Malabsorption Syndromes, Obesity, Thyroxine, Triiodothyronine
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