The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Dimorphic Cardiac Adaptation to Obesity and Arterial Hypertension
Abstract
Cardiovascular function and structure were evaluated by M-mode echocardiography and systemic hemodynamics in paired lean and obese patients, either hypertensive or normotensive. Compared to lean patients, obese patients had greater left atrial (p less than 0.0001), ventricular (p less than 0.001), and aortic root (p less than 0.002) diameters; posterior and septal wall thickness (p less than 0.001); and ventricular mass, cardiac output, stroke volume, and stroke work (all p less than 0.0001). Hypertensive patients had increased posterior wall thickness, end diastolic wall stress, stroke work (p less than 0.01), and a lower radius to posterior wall thickness ratio indicating concentric hypertrophy (p less than 0.001) when compared to normotensive patients. Cardiac adaptation to obesity consists of left ventricular dilatation and hypertrophy (eccentric hypertrophy) irrespective of arterial pressure levels. In contrast, essential hypertension solely produces concentric hypertrophy. Both obesity and hypertension increase left ventricular stroke work by disparate hemodynamic mechanisms; their presence in the same patient will tax the heart and increase the long-term risk of congestive failure.
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Cites
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Pathophysiologic assessment of hypertensive heart disease with echocardiography
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Self-citationIs arterial pressure the sole factor responsible for hypertensive cardiac hypertrophy?
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Self-citationBlood volume, cardiac output, and distribution of systemic blood flow in extreme obesity.
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Cited by
Poirier, P., Giles, T. D., Bray, G. A., Hong, Y., Stern, J. S., Pi-Sunyer, F. X., & Eckel, R. H. (2006) · Circulation · doi:10.1161/circulationaha.106.171016 · Cited by 3,165
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
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Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension
Ganau, A., Devereux, R. B., Roman, M. J., de Simone, G., Pickering, T. G., Saba, P. S., Vargiu, P., Simongini, I., & Laragh, J. H. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90617-v · Cited by 1,605
Metadata
- Authors
- MESSERLI, F. H., SUNDGAARD-RIISE, K., REISIN, E. D., DRESLINSKI, G. R., VENTURA, H. O., OIGMAN, W., FROHLICH, E. D., & DUNN, F. G.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1983-12-01
- Volume
- 99
- Issue
- 6
- Pages
- 757-761
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2036845216
- Cited by
- 338
- References
- 21
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- MESSERLI, F. H., SUNDGAARD-RIISE, K., REISIN, E. D., DRESLINSKI, G. R., VENTURA, H. O., OIGMAN, W., FROHLICH, E. D., & DUNN, F. G. (1983). Dimorphic Cardiac Adaptation to Obesity and Arterial Hypertension. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-99-6-757
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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