Treatment of Dilated Cardiomyopathy With Interleukin-1 Inhibition
Abstract
Letters4 December 2018Treatment of Dilated Cardiomyopathy With Interleukin-1 InhibitionGiacomo De Luca, MD, Corrado Campochiaro, MD, Charles A. Dinarello, MD, Lorenzo Dagna, MD, and Giulio Cavalli, MDGiacomo De Luca, MDVita-Salute San Raffaele University and Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy (G.D., C.C., L.D., G.C.), Corrado Campochiaro, MDVita-Salute San Raffaele University and Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy (G.D., C.C., L.D., G.C.), Charles A. Dinarello, MDUniversity of Colorado Denver, Aurora, Colorado (C.A.D.), Lorenzo Dagna, MDVita-Salute San Raffaele University and Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy (G.D., C.C., L.D., G.C.), and Giulio Cavalli, MDVita-Salute San Raffaele University and Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy (G.D., C.C., L.D., G.C.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L18-0315 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Dilated cardiomyopathy is a severe, irreversible form of heart disease characterized by left ventricular systolic dysfunction and dilation that are not explained by abnormal loading or coronary artery disease. The current mainstay of treatment is symptomatic management of heart failure and arrhythmia. Novel, effective therapeutic options are an unmet clinical need (1). The central role of inflammation in heart failure is now established, and the heart exhibits a stereotyped inflammatory response to injury that is mediated by interleukin-1. Selective inhibition of this cytokine has thus emerged as an intriguing therapeutic opportunity (2).Objective: To report the results of treatment ...References1. Merlo M, Cannatà A, Gobbo M, Stolfo D, Elliott PM, Sinagra G. Evolving concepts in dilated cardiomyopathy. Eur J Heart Fail. 2018;20:228-39. [PMID: 29271570] doi:10.1002/ejhf.1103 CrossrefMedlineGoogle Scholar2. Buckley LF, Abbate A. Interleukin-1 blockade in cardiovascular diseases: a clinical update. Eur Heart J. 2018;39:2063-9. [PMID: 29584915] doi:10.1093/eurheartj/ehy128 CrossrefMedlineGoogle Scholar3. Cavalli G, Dinarello CA. Treating rheumatological diseases and co-morbidities with interleukin-1 blocking therapies. Rheumatology (Oxford). 2015;54:2134-44. [PMID: 26209330] doi:10.1093/rheumatology/kev269 CrossrefMedlineGoogle Scholar4. Cavalli G, Pappalardo F, Mangieri A, Dinarello CA, Dagna L, Tresoldi M. Treating life-threatening myocarditis by blocking interleukin-1. Crit Care Med. 2016;44:e751-4. [PMID: 27031379] doi:10.1097/CCM.0000000000001654 CrossrefMedlineGoogle Scholar5. De Luca G, Cavalli G, Campochiaro C, Tresoldi M, Dagna L. Myocarditis: an interleukin-1-mediated disease? Front Immunol. 2018;9:1335. [PMID: 29951067] doi:10.3389/fimmu.2018.01335 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Vita-Salute San Raffaele University and Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy (G.D., C.C., L.D., G.C.)University of Colorado Denver, Aurora, Colorado (C.A.D.)Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L18-0315.This article was published at Annals.org on 31 July 2018. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Spectrum of COVID-19-Associated Myocarditis: A Patient-Tailored Multidisciplinary ApproachThe Genetic Pathways Underlying Immunotherapy in Dilated CardiomyopathyAnakinra for patients with COVID-19: a meta-analysis of non-randomized cohort studies.Interleukin-1 and Systemic Sclerosis: Getting to the Heart of Cardiac InvolvementCanakinumab injection for the treatment of active Still's disease, including adult-onset Still's diseaseInterleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseasesRepurposing of Biologic and Targeted Synthetic Anti-Rheumatic Drugs in COVID-19 and Hyper-Inflammation: A Comprehensive Review of Available and Emerging Evidence at the Peak of the PandemicCurrent treatment options and safety considerations when treating adult-onset Still's diseaseAntiarrhythmic efficacy of anakinra in a young patient with autoimmune lymphocytic myocarditisSystemic sclerosis myocarditis has unique clinical, histological and prognostic features: a comparative histological analysisTherapeutic strategies for virus-negative myocarditis: a comprehensive reviewTargeting the Immune System for Pulmonary Inflammation and Cardiovascular Complications in COVID-19 PatientsAutophagy and Protein SecretionAutophagy in the regulation of protein secretion in immune cellsEfficacy and safety of mycophenolate mofetil in
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Anakinra has demonstrated improvements in symptoms and systolic function in myocarditis and inflammatory cardiomyopathy.
“Anakinra has demonstrated improvements in symptoms and systolic function in myocarditis and inflammatory cardiomyopathy [113,114,115].”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [115]
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- Authors
- De Luca, G., Campochiaro, C., Dinarello, C. A., Dagna, L., & Cavalli, G.
- Affiliations
- Vita-Salute San Raffaele University and Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Scientific Institute, Milan, Italy (G.D., C.C., L.D., G.C.)
- Vita-Salute San Raffaele University (IT)
- University of Colorado Denver (US)
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2018-12-04
- Volume
- 169
- Issue
- 11
- Pages
- 819-820
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2885064222
- Cited by
- 42
- References
- 6
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 3
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- interleukin-1 inhibition, interleukin-1 receptor antagonist, inflammation in heart failure, left ventricular systolic dysfunction, heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, heart failure
- MeSH terms
- Cardiomyopathy, Dilated, Humans, Male, Middle Aged, Treatment Outcome, Interleukin 1 Receptor Antagonist Protein
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