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Cited by 281Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysAbdominal Surgery and Complications

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis

Fernando, Shannon M., Tran, Alexandre, Taljaard, Monica, Cheng, Wei, Rochwerg, Bram, Seely, Andrew J.E., Perry, Jeffrey J.·2018·Annals of Internal Medicine
DOI 10.7326/m17-2820
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Abstract

Background: The quick Sequential Organ Failure Assessment (qSOFA) has been proposed for prediction of mortality in patients with suspected infection. Purpose: To summarize and compare the prognostic accuracy of qSOFA and the systemic inflammatory response syndrome (SIRS) criteria for prediction of mortality in adult patients with suspected infection. Data Sources: Four databases from inception through November 2017. Study Selection: English-language studies using qSOFA for prediction of mortality (in-hospital, 28-day, or 30-day) in adult patients with suspected infection in the intensive care unit (ICU), emergency department (ED), or hospital wards. Data Extraction: Two investigators independently extracted data and assessed study quality using standard criteria. Data Synthesis: Thirty-eight studies were included (n = 385 333). qSOFA was associated with a pooled sensitivity of 60.8% (95% CI, 51.4% to 69.4%) and a pooled specificity of 72.0% (CI, 63.4% to 79.2%) for mortality. The SIRS criteria were associated with a pooled sensitivity of 88.1% (CI, 82.3% to 92.1%) and a pooled specificity of 25.8% (CI, 17.1% to 36.9%). The pooled sensitivity of qSOFA was higher in the ICU population (87.2% [CI, 75.8% to 93.7%]) than the non-ICU population (51.2% [CI, 43.6% to 58.7%]). The pooled specificity of qSOFA was higher in the non-ICU population (79.6% [CI, 73.3% to 84.7%]) than the ICU population (33.3% [CI, 23.8% to 44.4%]). Limitation: Potential risk of bias in included studies due to qSOFA interpretation and patient selection. Conclusion: qSOFA had poor sensitivity and moderate specificity for short-term mortality. The SIRS criteria had sensitivity superior to that of qSOFA, supporting their use for screening of patients and as a prompt for treatment initiation. Primary Funding Source: Canadian Association of Emergency Physicians. (PROSPERO: CRD42017075964).

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  1. Takwoingi Y, 2010, User Guide Version 1.3
  2. 10.1001/jama.1995.03520260039030 · DOI

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Metadata

Authors
Fernando, S. M., Tran, A., Taljaard, M., Cheng, W., Rochwerg, B., Seely, A. J. E., & Perry, J. J.
Affiliations
  • University of Ottawa (CA)
  • Ottawa Hospital Research Institute (CA)
  • McMaster University (CA)
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2018-02-20
Volume
168
Issue
4
Pages
266-275
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/m17-2820
OpenAlex
W2788736459
Cited by
281
References
69
Citations by year
2026: 24 · 2025: 18 · 2024: 23 · 2023: 36 · 2022: 34 · 2021: 33 · 2020: 38 · 2019: 49 · 2018: 25
FWCI
5.18
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
  • Health Sciences › Medicine › Surgery › Abdominal Surgery and Complications
Keywords
qSOFA, systemic inflammatory response syndrome, mortality prediction, suspected infection, prognostic accuracy, sensitivity and specificity, intensive care unit, emergency department, sepsis screening
MeSH terms
Decision Support Techniques, Emergency Service, Hospital, Humans, Intensive Care Units, Predictive Value of Tests, Prognosis, Hospital Mortality, Systemic Inflammatory Response Syndrome, Sepsis, Organ Dysfunction Scores

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