The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma
Open accessAbstract
Neurotrophin-3 (Ntf3) and brain derived neurotrophic factor (Bdnf) are critical for sensory neuron survival and establishment of neuronal projections to sensory epithelia in the embryonic inner ear, but their postnatal functions remain poorly understood. Using cell-specific inducible gene recombination in mice we found that, in the postnatal inner ear, Bbnf and Ntf3 are required for the formation and maintenance of hair cell ribbon synapses in the vestibular and cochlear epithelia, respectively. We also show that supporting cells in these epithelia are the key endogenous source of the neurotrophins. Using a new hair cell CreERT line with mosaic expression, we also found that Ntf3's effect on cochlear synaptogenesis is highly localized. Moreover, supporting cell-derived Ntf3, but not Bbnf, promoted recovery of cochlear function and ribbon synapse regeneration after acoustic trauma. These results indicate that glial-derived neurotrophins play critical roles in inner ear synapse density and synaptic regeneration after injury.
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Cited by
Al‐Moyed, H., Cepeda, A. P., Jung, S., Moser, T., Kügler, S., & Reisinger, E. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809396 · Cited by 230
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Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain
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One, Two, Three, Four! How Multiple RRMs Read the Genome Sequence
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Neurotrophic Factors and Their Potential Applications in Tissue Regeneration
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Metadata
- Authors
- Wan, G., Gómez-Casati, M. E., Gigliello, A. R., Liberman, M. C., & Corfas, G.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2014-10-20
- Volume
- 3
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2112722770
- Cited by
- 264
- References
- 45
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. https://app.cochat.ai/papers/10.7554/elife.03564
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- Wan, G., Gómez-Casati, M. E., Gigliello, A. R., Liberman, M. C., & Corfas, G. (2014). Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. eLife. https://doi.org/10.7554/elife.03564
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