Neurotrophic Factors and Their Potential Applications in Tissue Regeneration
Open accessAbstract
Neurotrophic factors are growth factors that can nourish neurons and promote neuron survival and regeneration. They have been studied as potential drug candidates for treating neurodegenerative diseases. Since their identification, there are more and more evidences to indicate that neurotrophic factors are also expressed in non-neuronal tissues and regulate the survival, anti-inflammation, proliferation and differentiation in these tissues. This mini review summarizes the characteristics of the neurotrophic factors and their potential clinical applications in the regeneration of neuronal and non-neuronal tissues.
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In the CNS, plasticity is modulated by neurotrophic factors, which promote neuronal growth, survival, and regeneration.
“In the CNS, this plasticity is modulated by neurotrophic factors, which promote neuronal growth, survival, and regeneration, and are commonly referred to as neurotrophins (Xiao and Le, 2016).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Xiao and Le, 2016
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- Authors
- Xiao, N., & Le, Q.-T.
- Affiliations
- University of the Pacific (US)
- Stanford Medicine (US)
- Corresponding author
- Xiao, Nan
- Venue
- Archivum Immunologiae et Therapiae Experimentalis
- Publisher
- Walter de Gruyter GmbH
- Published
- 2015-11-26
- Volume
- 64
- Issue
- 2
- Pages
- 89-99
- ISSN
- 0004-069X (ISSN-L)
- 1661-4917
- PMC
- PMC4805470
- OpenAlex
- W2180157788
- Cited by
- 93
- References
- 212
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 7 · 2022: 15 · 2021: 8 · 2020: 17 · 2019: 10 · 2018: 5 · 2016: 2
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archivum Immunologiae et Therapiae Experimentalis (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Scholarly Commons (University of the Pacific) (submittedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R01DE025227)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- neurotrophic factors, tissue regeneration, neurodegenerative diseases, neuronal survival, neuronal regeneration, non-neuronal tissues, anti-inflammation, cell proliferation, cell differentiation, growth factors, clinical application
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Differentiation, Cell Survival, Humans, Nerve Growth Factors, Neurons, Neurodegenerative Diseases, Guided Tissue Regeneration, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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