Cited by 93Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsNuclear Receptors and Signaling

Neurotrophic Factors and Their Potential Applications in Tissue Regeneration

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Xiao, Nan, Le, Quynh-Thu·2016·Archivum Immunologiae et Therapiae Experimentalis

Abstract

Neurotrophic factors are growth factors that can nourish neurons and promote neuron survival and regeneration. They have been studied as potential drug candidates for treating neurodegenerative diseases. Since their identification, there are more and more evidences to indicate that neurotrophic factors are also expressed in non-neuronal tissues and regulate the survival, anti-inflammation, proliferation and differentiation in these tissues. This mini review summarizes the characteristics of the neurotrophic factors and their potential clinical applications in the regeneration of neuronal and non-neuronal tissues.

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  1. Meng FF Xu Y Dan QQ 2015 Intrathecal injection of lentivirus-mediated GDNF interference RNA relieves bone cancer induced pain in rats Cancer Sci 106 430 437 25611164 PMC4409887

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Authors
Xiao, N., & Le, Q.-T.
Affiliations
  • University of the Pacific (US)
  • Stanford Medicine (US)
Corresponding author
Xiao, Nan
Venue
Archivum Immunologiae et Therapiae Experimentalis
Published
2015-11-26
Volume
64
Issue
2
Pages
89-99
ISSN
  • 0004-069X (ISSN-L)
  • 1661-4917
OpenAlex
W2180157788
Cited by
93
References
212
Citations by year
2026: 5 · 2025: 11 · 2024: 13 · 2023: 7 · 2022: 15 · 2021: 8 · 2020: 17 · 2019: 10 · 2018: 5 · 2016: 2
FWCI
0.28
Type
journal article
Language
en
Open access
Locations
  • Archivum Immunologiae et Therapiae Experimentalis (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Scholarly Commons (University of the Pacific) (submittedVersion)
Funders
National Institute of Dental and Craniofacial Research (R01DE025227)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
neurotrophic factors, tissue regeneration, neurodegenerative diseases, neuronal survival, neuronal regeneration, non-neuronal tissues, anti-inflammation, cell proliferation, cell differentiation, growth factors, clinical application
MeSH terms
Animals, Anti-Inflammatory Agents, Cell Differentiation, Cell Survival, Humans, Nerve Growth Factors, Neurons, Neurodegenerative Diseases, Guided Tissue Regeneration, Cell Proliferation

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