The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor
Open accessAbstract
Innate lymphoid cells (ILCs) are recently identified lymphocytes that limit infection and promote tissue repair at mucosal surfaces. However, the pathways underlying ILC development remain unclear. Here we show that the transcription factor NFIL3 directs the development of a committed bone marrow precursor that differentiates into all known ILC lineages. NFIL3 was required in the common lymphoid progenitor (CLP), and was essential for the differentiation of αLP, a bone marrow cell population that gives rise to all known ILC lineages. Clonal differentiation studies revealed that CXCR6+ cells within the αLP population differentiate into all ILC lineages but not T- and B-cells. We further show that NFIL3 governs ILC development by directly regulating expression of the transcription factor TOX. These findings establish that NFIL3 directs the differentiation of a committed ILC precursor that gives rise to all ILC lineages and provide insight into the defining role of NFIL3 in ILC development.
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Citations
Cites
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity
Spencer, S. P., Wilhelm, C., Yang, Q., Hall, J. A., Bouladoux, N., Boyd, A., Nutman, T. B., Urban, J. F., Wang, J., Ramalingam, T. R., et al. (2014) · Science · doi:10.1126/science.1247606 · Cited by 447
Cited by
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
Sonnenberg, G. F., & Artis, D. (2015) · Nature Medicine · doi:10.1038/nm.3892 · Cited by 503
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
Wang, Y., Kuang, Z., Yu, X., Ruhn, K. A., Kubo, M., & Hooper, L. V. (2017) · Science · doi:10.1126/science.aan0677 · Cited by 456
Self-citationSingle-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway
Yu, Y., Tsang, J. C. H., Wang, C., Clare, S., Wang, J., Chen, X., Brandt, C., Kane, L., Campos, L. S., Lu, L., et al. (2016) · Nature · doi:10.1038/nature20105 · Cited by 306
Innate Lymphoid Cell Development: A T Cell Perspective
Cherrier, D. E., Serafini, N., & Di Santo, J. P. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.010 · Cited by 181
The origin and role of innate lymphoid cells in the lung
Lai, D.-M., Shu, Q., & Fan, J. (2016) · Military Medical Research · doi:10.1186/s40779-016-0093-2 · Cited by 45
Metadata
- Authors
- Yu, X., Wang, Y., Deng, M., Li, Y., Ruhn, K. A., Zhang, C. C., & Hooper, L. V.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2014-10-13
- Volume
- 3
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2155358087
- Cited by
- 244
- References
- 2
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- gold
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- Yu, X., Wang, Y., Deng, M., Li, Y., Ruhn, K. A., Zhang, C. C., & Hooper, L. V. (2014). The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. eLife. https://doi.org/10.7554/elife.04406
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