The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
Open accessAbstract
Light, fat, and commensals: The gut microbiota facilitates energy harvest from food and transfers it into fat storage. Working in mice, Wang et al. found that an epithelial cell circadian transcription factor, NFIL3, is involved in regulating body composition through lipid uptake. Flagellin and lipopolysaccharide produced by certain microbes tuned the amplitude of oscillation of NFIL3 through innate lymphoid cell (ILC3) signaling, STAT3, and the epithelial cell clock. Such interactions may help to explain why circadian clock disruptions in humans, arising from shift work or international travel, frequently track with metabolic diseases, including obesity, diabetes, and cardiovascular disease. Science , this issue p. 912
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- Authors
- Wang, Y., Kuang, Z., Yu, X., Ruhn, K. A., Kubo, M., & Hooper, L. V.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Tokyo University of Science (JP)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Hooper, Lora V.
- Venue
- Science
- Published
- 2017-09
- Volume
- 357
- Issue
- 6354
- Pages
- 912-916
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5702268
- OpenAlex
- W2751705979
- Cited by
- 456
- References
- 37
- Citations by year
- 2026: 38 · 2025: 51 · 2024: 56 · 2023: 57 · 2022: 67 · 2021: 50 · 2020: 56 · 2019: 48 · 2018: 25 · 2017: 7
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (award303994, DK070855)
- Howard Hughes Medical Institute (award303995)
- Burroughs Wellcome Fund (award303996, 1007035)
- Welch Foundation (award303997, I-1874)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- gut microbiota, body composition, NFIL3, circadian clock, ILC3, STAT3, intestinal epithelial cells, circadian transcription, lipid metabolism, fat absorption, lipid export, host metabolism
- MeSH terms
- Gastrointestinal Microbiome, Animals, Body Composition, Circadian Rhythm, Germ-Free Life, Glucose Tolerance Test, Insulin Resistance, Intestines, Obesity, Promoter Regions, Genetic, Transcription, Genetic, Mice, Knockout, Lipid Metabolism, STAT3 Transcription Factor, Basic-Leucine Zipper Transcription Factors, Mice, Nuclear Receptor Subfamily 1, Group D, Member 1, Circadian Clocks, Diet, High-Fat
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