The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Conservation of transcription factor binding specificities across 600 million years of bilateria evolution
Open accessAbstract
Divergent morphology of species has largely been ascribed to genetic differences in the tissue-specific expression of proteins, which could be achieved by divergence in cis-regulatory elements or by altering the binding specificity of transcription factors (TFs). The relative importance of the latter has been difficult to assess, as previous systematic analyses of TF binding specificity have been performed using different methods in different species. To address this, we determined the binding specificities of 242 Drosophila TFs, and compared them to human and mouse data. This analysis revealed that TF binding specificities are highly conserved between Drosophila and mammals, and that for orthologous TFs, the similarity extends even to the level of very subtle dinucleotide binding preferences. The few human TFs with divergent specificities function in cell types not found in fruit flies, suggesting that evolution of TF specificities contributes to emergence of novel types of differentiated cells.
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Cited by
The Human Transcription Factors
Lambert, S. A., Jolma, A., Campitelli, L. F., Das, P. K., Yin, Y., Albu, M., Chen, X., Taipale, J., Hughes, T. R., & Weirauch, M. T. (2018) · Cell · doi:10.1016/j.cell.2018.01.029 · Cited by 3,399
Self-citationImpact of cytosine methylation on DNA binding specificities of human transcription factors
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Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution
Long, H. K., Prescott, S. L., & Wysocka, J. (2016) · Cell · doi:10.1016/j.cell.2016.09.018 · Cited by 945
The origin and evolution of cell types
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Metadata
- Authors
- Nitta, K. R., Jolma, A., Yin, Y., Morgunova, E., Kivioja, T., Akhtar, J., Hens, K., Toivonen, J., Deplancke, B., Furlong, E. E. M., & Taipale, J.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2015-03-17
- Volume
- 4
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2170964754
- Cited by
- 365
- References
- 70
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Nitta, K. R., Jolma, A., Yin, Y., Morgunova, E., Kivioja, T., Akhtar, J., Hens, K., Toivonen, J., Deplancke, B., Furlong, E. E. M., & Taipale, J. (2015). Conservation of transcription factor binding specificities across 600 million years of bilateria evolution. eLife. https://doi.org/10.7554/elife.04837
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