Transcription regulation and animal diversity
Abstract
Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.
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Conserved linkage groups representing ancestral vertebrate chromosomes can be defined by comparing fish and mammalian genomes despite modest conserved gene order.
“Conserved linkage groups representing ancestral vertebrate chromosomes can be defined by comparing fish and mammalian genomes and genetic maps, despite the presence of only modest segments of conserved gene order (48,49).”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [49]
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- Authors
- Levine, M., & Tjian, R.
- Affiliations
- University of California, Berkeley (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Levine, Michael
- Tjian, Robert
- Venue
- Nature
- Published
- 2003-07
- Volume
- 424
- Issue
- 6945
- Pages
- 147-151
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2128937741
- Cited by
- 1,309
- References
- 1
- Citations by year
- 2026: 30 · 2025: 35 · 2024: 45 · 2023: 45 · 2022: 35 · 2021: 33 · 2020: 33 · 2019: 40 · 2018: 31 · 2017: 43 · 2016: 40 · 2015: 52 · 2014: 46 · 2013: 71 · 2012: 52
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- transcriptional regulation, gene expression regulation, animal biodiversity, comparative genomics, gene duplication, genome size, organismal complexity, vertebrate genomes, invertebrate genomes, evolution of complexity
- MeSH terms
- Animals, Chromatin, DNA, Gene Expression Regulation, Humans, Regulatory Sequences, Nucleic Acid, Transcription Factors, Transcription, Genetic, Ecosystem
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