The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
A platform for brain-wide imaging and reconstruction of individual neurons
Open accessAbstract
The structure of axonal arbors controls how signals from individual neurons are routed within the mammalian brain. However, the arbors of very few long-range projection neurons have been reconstructed in their entirety, as axons with diameters as small as 100 nm arborize in target regions dispersed over many millimeters of tissue. We introduce a platform for high-resolution, three-dimensional fluorescence imaging of complete tissue volumes that enables the visualization and reconstruction of long-range axonal arbors. This platform relies on a high-speed two-photon microscope integrated with a tissue vibratome and a suite of computational tools for large-scale image data. We demonstrate the power of this approach by reconstructing the axonal arbors of multiple neurons in the motor cortex across a single mouse brain.
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Cites
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Self-citationOptical Sectioning Deep Inside Live Embryos by Selective Plane Illumination Microscopy
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Self-citationUltramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain
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Hierarchical organization of cortical and thalamic connectivity
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Self-citationNeuronal cell-type classification: challenges, opportunities and the path forward
Zeng, H., & Sanes, J. R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.85 · Cited by 841
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Self-citationHigh-throughput mapping of single-neuron projections by sequencing of barcoded RNA
Kebschull, J. M., Garcia da Silva, P., Reid, A. P., Peikon, I. D., Albeanu, D. F., & Zador, A. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.036 · Cited by 376
Metadata
- Authors
- Economo, M. N., Clack, N. G., Lavis, L. D., Gerfen, C. R., Svoboda, K., Myers, E. W., & Chandrashekar, J.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-01-20
- Volume
- 5
- Pages
- e10566-e10566
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2279851379
- Cited by
- 409
- References
- 68
- FWCI
- 32.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- Economo, M. N., Clack, N. G., Lavis, L. D., Gerfen, C. R., Svoboda, K., Myers, E. W., & Chandrashekar, J. (2016). A platform for brain-wide imaging and reconstruction of individual neurons. eLife. https://doi.org/10.7554/elife.10566
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