The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Mitochondrial DNA copy number variation across human cancers
Open accessAbstract
Mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), are observed throughout cancers. Here, we survey mtDNA copy number variation across 22 tumor types profiled by The Cancer Genome Atlas project. We observe a tendency for some cancers, especially of the bladder, breast, and kidney, to be depleted of mtDNA, relative to matched normal tissue. Analysis of genetic context reveals an association between incidence of several somatic alterations, including IDH1 mutations in gliomas, and mtDNA content. In some but not all cancer types, mtDNA content is correlated with the expression of respiratory genes, and anti-correlated to the expression of immune response and cell-cycle genes. In tandem with immunohistochemical evidence, we find that some tumors may compensate for mtDNA depletion to sustain levels of respiratory proteins. Our results highlight the extent of mtDNA copy number variation in tumors and point to related therapeutic opportunities.
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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
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Self-citationMetabolic landscape of the tumor microenvironment at single cell resolution
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Mitochondrial DNA copy number in human disease: the more the better?
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Mitochondrial DNA variation and cancer
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Metadata
- Authors
- Reznik, E., Miller, M. L., Şenbabaoğlu, Y., Riaz, N., Sarungbam, J., Tickoo, S. K., Al-Ahmadie, H. A., Lee, W., Seshan, V. E., Hakimi, A. A., & Sander, C.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-02-22
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2280727461
- Cited by
- 530
- References
- 18
- FWCI
- 23.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- Reznik, E., Miller, M. L., Şenbabaoğlu, Y., Riaz, N., Sarungbam, J., Tickoo, S. K., Al-Ahmadie, H. A., Lee, W., Seshan, V. E., Hakimi, A. A., & Sander, C. (2016). Mitochondrial DNA copy number variation across human cancers. eLife. https://doi.org/10.7554/elife.10769
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