The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes
Open accessAbstract
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan parasites has been overlooked for decades as these pathogens have been regarded primarily as blood-dwelling organisms. Intriguingly, infections with low or undetected blood parasites are common, particularly in the case of Human African Trypanosomiasis caused by Trypanosoma brucei gambiense. We hypothesise, therefore, the skin represents an anatomic reservoir of infection. Here we definitively show that substantial quantities of trypanosomes exist within the skin following experimental infection, which can be transmitted to the tsetse vector, even in the absence of detectable parasitaemia. Importantly, we demonstrate the presence of extravascular parasites in human skin biopsies from undiagnosed individuals. The identification of this novel reservoir requires a re-evaluation of current diagnostic methods and control policies. More broadly, our results indicate that transmission is a key evolutionary force driving parasite extravasation that could further result in tissue invasion-dependent pathology.
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Cites
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Cited by
Tissue tropism in parasitic diseases
Silva Pereira, S., Trindade, S., De Niz, M., & Figueiredo, L. M. (2019) · Open Biology · doi:10.1098/rsob.190036 · Cited by 85
Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody
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Metadata
- Authors
- Capewell, P., Cren-Travaillé, C., Marchesi, F., Johnston, P., Clucas, C., Benson, R. A., Gorman, T.-A., Calvo-Alvarez, E., Crouzols, A., Jouvion, G., Jamonneau, V., Weir, W., Stevenson, M. L., O'Neill, K., Cooper, A., Swar, N.-R. K., Bucheton, B., Ngoyi, D. M., Garside, P., Rotureau, B., & MacLeod, A.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-09-22
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2522471325
- Cited by
- 286
- References
- 28
- FWCI
- 25.08
- Type
- journal article
- Language
- en
- Open access
- gold
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- Capewell, P., Cren-Travaillé, C., Marchesi, F., Johnston, P., Clucas, C., Benson, R. A., Gorman, T.-A., Calvo-Alvarez, E., Crouzols, A., Jouvion, G., Jamonneau, V., Weir, W., Stevenson, M. L., O'Neill, K., Cooper, A., Swar, N.-R. K., Bucheton, B., Ngoyi, D. M., Garside, P., . . . MacLeod, A. (2016). The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife. https://doi.org/10.7554/elife.17716
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