The history of African trypanosomiasis
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The prehistory of African trypanosomiasis indicates that the disease may have been an important selective factor in the evolution of hominids. Ancient history and medieval history reveal that African trypanosomiasis affected the lives of people living in sub-Saharan African at all times. Modern history of African trypanosomiasis revolves around the identification of the causative agents and the mode of transmission of the infection, and the development of drugs for treatment and methods for control of the disease. From the recent history of sleeping sickness we can learn that the disease can be controlled but probably not be eradicated. Current history of human African trypanosomiasis has shown that the production of anti-sleeping sickness drugs is not always guaranteed, and therefore, new, better and cheaper drugs are urgently required.
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During trypanosome infection, listlessness and emaciation are clinical signs of the infection.
“Furthermore, during trypanosome infection, listlessness and emaciation are some of the clinical signs of the infection (Nantulya, 1986; Steverding, 2008; Noyes et al., 2011).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Steverding, 2008
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Cites
(1973) · Annals of Internal Medicine · doi:10.7326/0003-4819-79-2-324_1 · Cited by 997 · see citing works
Vreysen, M. J. B., Saleh, K. M., Ali, M. Y., Abdulla, A. M., Zhu, Z.-R., Juma, K. G., Dyck, V. A., Msangi, A. R., Mkonyi, P. A., & Feldmann, H. U. (2000) · Journal of Economic Entomology · doi:10.1603/0022-0493-93.1.123 · Cited by 477 · see citing works
(1954) · Leprosy Review · doi:10.5935/0305-7518.19540020 · Cited by 412 · see citing works
Development of difluoromethylornithine (DFMO) as a chemoprevention agent.
Meyskens, F. L., & Gerner, E. W. (1999) · PubMed · Cited by 337 · see citing works
Jolly, D., Prentice, I. C., Bonnefille, R., Ballouche, A., Bengo, M. D., Brénac, P., Buchet, G., Burney, D. A., Cazet, J.-P., Cheddadi, R., et al. (1998) · Journal of Biogeography · doi:10.1046/j.1365-2699.1998.00238.x · Cited by 332 · see citing works
Drugs and drug resistance in African trypanosomiasis
Delespaux, V., & de Koning, H. P. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.02.004 · Cited by 287 · see citing works
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future
Bray, P. G., Barrett, M. P., Ward, S. A., & de Koning, H. P. (2003) · Trends in Parasitology · doi:10.1016/s1471-4922(03)00069-2 · Cited by 261 · see citing works
The Papyrus Ebers; The Greatest Egyptian Medical Document
Dawson, W. R., & EBBELL, Β. (1938) · The Journal of Egyptian Archaeology · doi:10.2307/3854804 · Cited by 224 · see citing works
The molecular phylogeny of trypanosomes: evidence for an early divergence of the Salivaria
Haag, J. (1998) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(97)00185-0 · Cited by 185 · see citing works
Peet, T. E. (1931) · The Journal of Egyptian Archaeology · doi:10.1177/030751333101700126 · Cited by 183 · see citing works
Wild fauna as a probable animal reservoir for Trypanosoma brucei gambiense in Cameroon
Njiokou, F., Laveissière, C., Simo, G., Nkinin, S. W., Grébaut, P., Cuny, G., & Herder, S. (2005) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2005.04.003 · Cited by 150 · see citing works
Aiming to eliminate tsetse from Africa
Kabayo, J. P. (2002) · Trends in Parasitology · doi:10.1016/s1471-4922(02)02371-1 · Cited by 149 · see citing works
History of Sleeping Sickness in East Africa
Hide, G. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.1.112 · Cited by 136 · see citing works
Human African trypanosomiasis (sleeping sickness): epidemiological update.
(2006) · PubMed · Cited by 134 · see citing works
A gene expressed only in serum-resistant variants of Trypanosoma brucei rhodesiense
Greef, C. D., Imberechts, H., Matthyssens, G. E., Meirvenne, N. V., & HAMERS, R. (1989) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(89)90189-8 · Cited by 116 · see citing works
Simo, G., Asonganyi, T., Nkinin, S. W., Njiokou, F., & Herder, S. (2006) · Veterinary Parasitology · doi:10.1016/j.vetpar.2006.02.026 · Cited by 116 · see citing works
Priotto, G., Fogg, C., Balasegaram, M., Erphas, O., Louga, A., Checchi, F., Ghabri, S., & Piola, P. (2006) · PLoS Clinical Trials · doi:10.1371/journal.pctr.0010039 · Cited by 108 · see citing works
Bisser, S., N’Siesi, F., Lejon, V., Preux, P., Nieuwenhove, S. V., Bilenge, C. M. M., & Büscher, P. (2007) · The Journal of Infectious Diseases · doi:10.1086/510534 · Cited by 105 · see citing works
The Colonial Disease: A Social History of Sleeping Sickness in Northern Zaire, 1900-1940
Wylie, D., & Lyons, M. (1994) · Canadian Journal of African Studies / Revue canadienne des études africaines · doi:10.2307/485358 · Cited by 98 · see citing works
African Trypanosomiasis (Sleeping Sickness)
(2024) · doi:10.1542/9781610027359-s3_019_013 · Cited by 91 · see citing works
History of sleeping sickness (African trypanosomiasis)
Cox, F. E. G. (2004) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2004.01.004 · Cited by 82 · see citing works
Trypanosomiasis and leishmaniasis.
Pd, M., & Wh, L. (1971) · PubMed · Cited by 72 · see citing works
Stephens, J. W. W., & Fantham, H. B. (1910) · Proceedings of the Royal Society of London Series B Containing Papers of a Biological Character · doi:10.1098/rspb.1910.0064 · Cited by 58 · see citing works
The Wellcome Trust Illustrated History of Tropical Diseases
Cox, F. (1996) · Cited by 48 · see citing works
Pharmacology of existing drugs for animal trypanosomiasis
Kinabo, L. D. B. (1993) · Acta Tropica · doi:10.1016/0001-706x(93)90091-o · Cited by 47 · see citing works
Castellani, A. (1903) · Proceedings of the Royal Society of London · doi:10.1098/rspl.1902.0134 · Cited by 40 · see citing works
TheSRAgene: the key to understanding the nature ofTrypanosoma brucei rhodesiense
Gibson, W. (2005) · Parasitology · doi:10.1017/s0031182005007560 · Cited by 38 · see citing works
The Colonial Disease: A Social History of Sleeping Sickness in Northern Zaire, 1900-1940.
Packard, R. M., & Lyons, M. (1993) · The American Historical Review · doi:10.2307/2167672 · Cited by 28 · see citing works
Trypanosomes and Hominid Evolution
Lambrecht, F. L. (1985) · BioScience · doi:10.2307/1309990 · Cited by 25 · see citing works
Kea, R. A. (2004) · Journal of World-Systems Research · doi:10.5195/jwsr.2004.286 · Cited by 22 · see citing works
Manson's tropical diseases. 18th Edition.
Manson‐Bahr, P., & Apted, F. I. C. (1982) · Cited by 22 · see citing works
Landmarks in trypanosome research.
Vickerman, K., Hide, G., Mottram, J. C., Coombs, G. H., & Holmes, P. H. (1997) · Cited by 20 · see citing works
A new initiative for the development of new diagnostic tests for human African trypanosomiasis
Steverding, D. (2006) · Kinetoplastid Biology and Disease · doi:10.1186/1475-9292-5-1 · Cited by 17 · see citing works
Self-citationCastellani, A. (1903) · The Lancet · doi:10.1016/s0140-6736(01)70338-8 · Cited by 17 · see citing works
Geißeln der Menschheit – Kulturgeschichte der Seuchen
Winkle, S. (2007) · Pflege · doi:10.1024/1012-5302.20.2.119b · Cited by 15 · see citing works
African Trypanosomiasis (Sleeping Sickness)
Pépin, J., & Donelson, J. E. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3935-5.00098-7 · Cited by 9 · see citing works
Pan African group takes lead against the tsetse fly
Bhalla, N. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07843-1 · Cited by 9 · see citing works
Die Rückkehr einer Seuche: Trypanosomen
Stich, A., & Steverding, D. (2002) · Biologie in unserer Zeit · doi:10.1002/1521-415x(200209)32:5 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- WHO/CDS/CSR/ISR/2000.1 Chapter 8 – African trypanosomiasis WHO Report on Global Surveillance of Epidemic-prone Infectious Diseases 2000 World Health Organization 95 106
Cited by
Sorted by citations
Brun, R., Blum, J., Chappuis, F., & Burri, C. (2010) · The Lancet · doi:10.1016/s0140-6736(09)60829-1 · Cited by 926 · see citing works
The importance of vector control for the control and elimination of vector-borne diseases
Wilson, A. L., Courtenay, O., Kelly‐Hope, L. A., Scott, T. W., Takken, W., Torr, S. J., & Lindsay, S. W. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007831 · Cited by 894 · see citing works
Büscher, P., Cecchi, G., Jamonneau, V., & Priotto, G. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31510-6 · Cited by 711 · see citing works
Steverding, D. (2017) · Parasites & Vectors · doi:10.1186/s13071-017-2028-5 · Cited by 502 · see citing works
Self-citationThe animal trypanosomiases and their chemotherapy: a review
Giordani, F., Morrison, L. J., ROWAN, T. G., de Koning, H. P., & Barrett, M. P. (2016) · Parasitology · doi:10.1017/s0031182016001268 · Cited by 449 · see citing works
The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery
Wright, P. M., Seiple, I. B., & Myers, A. G. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201310843 · Cited by 427 · see citing works
Epidemiology of human African trypanosomiasis
Simarro, P. P., Franco, J., Diarra, A., & Jannin, J. G. (2014) · Clinical Epidemiology · doi:10.2147/clep.s39728 · Cited by 413 · see citing works
Recent Developments in Drug Discovery for Leishmaniasis and Human African Trypanosomiasis
Nagle, A. S., Khare, S., Kumar, A. B., Supek, F., Buchynskyy, A., Mathison, C. J. N., Chennamaneni, N. K., Pendem, N., C, F. S. B. A., Gelb, M. H., et al. (2014) · Chemical Reviews · doi:10.1021/cr500365f · Cited by 352 · see citing works
The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes
Capewell, P., Travaillé, C., Marchesi, F., Johnston, P., Clucas, C., Benson, R. A., Gorman, T.-A., Alvarez, E. C., Crouzols, A., Jouvion, G., et al. (2016) · eLife · doi:10.7554/elife.17716 · Cited by 289 · see citing works
The development of drugs for treatment of sleeping sickness: a historical review
Steverding, D. (2010) · Parasites & Vectors · doi:10.1186/1756-3305-3-15 · Cited by 276 · see citing works
Self-citationThe Genome Landscape of Indigenous African Cattle
Kim, J., Hanotte, O., Mwai, O. A., Dessie, T., Bashir, S., Diallo, B., Agaba, M., Kim, K., Kwak, W., Sung, S., et al. (2017) · Genome biology · doi:10.1186/s13059-017-1153-y · Cited by 271 · see citing works
Trypanocidal drugs: mechanisms, resistance and new targets
Wilkinson, S. R., & Kelly, J. M. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001252 · Cited by 240 · see citing works
Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal
Jamonneau, V., Ilboudo, H., Kaboré, J., Kaba, D., Koffi, M., Solano, P., Garcia, A., Courtin, D., Laveissière, C., Kouakou, L., et al. (2012) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001691 · Cited by 204 · see citing works
Steverding, D. (2014) · Parasites & Vectors · doi:10.1186/1756-3305-7-317 · Cited by 171 · see citing works
Self-citationDevelopment of Novel Drugs for Human African Trypanosomiasis
Brun, R., Don, R., Jacobs, R. T., Wang, M. Z., & Barrett, M. P. (2011) · Future Microbiology · doi:10.2217/fmb.11.44 · Cited by 138 · see citing works
Bushmeat and Emerging Infectious Diseases: Lessons from Africa
Kurpiers, L. A., Schulte‐Herbrüggen, B., Ejotre, I., & Reeder, D. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-22246-2_24 · Cited by 140 · see citing works
Trypanocidal Activity of Nitroaromatic Prodrugs: Current Treatments and Future Perspectives
Wilkinson, S. R., Bot, C., Kelly, J. M., & Hall, B. S. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611796575894 · Cited by 133 · see citing works
Cooper, A., Ilboudo, H., Alibu, V. P., Ravel, S., Enyaru, J., Weir, W., Noyes, H. A., Capewell, P., Camara, M., Milet, J., et al. (2017) · eLife · doi:10.7554/elife.25461 · Cited by 127 · see citing works
Avilán, L., Gualdrón‐López, M., Quiñones, W. A., González-González, L., Hannaert, V., Michels, P. A. M., & Concepción, J. L. (2011) · Enzyme Research · doi:10.4061/2011/932549 · Cited by 125 · see citing works
Wheeler, R. J., Scheumann, N., Wickstead, B., Keith Gull, B., & Vaughan, S. (2013) · Molecular Microbiology · doi:10.1111/mmi.12436 · Cited by 113 · see citing works
The journey towards elimination of gambiense human African trypanosomiasis: not far, nor easy
Franco, J. R., Simarro, P. P., DIARRA, A., Ruiz-Postigo, J. A., & Jannin, J. G. (2014) · Parasitology · doi:10.1017/s0031182013002102 · Cited by 107 · see citing works
Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes
Aphasizheva, I., Alfonzo, J. D., Carnes, J., Cestari, I. D. S., Cruz‐Reyes, J., Göringer, H. U., Hajduk, S. L., Lukeš, J., Madison‐Antenucci, S., Maslov, D. A., et al. (2020) · Trends in Parasitology · doi:10.1016/j.pt.2020.01.006 · Cited by 110 · see citing works
Combatting African Animal Trypanosomiasis (AAT) in livestock: The potential role of trypanotolerance
Yaro, M., Munyard, K. A., Stear, M. J., & Groth, D. M. (2016) · Veterinary Parasitology · doi:10.1016/j.vetpar.2016.05.003 · Cited by 114 · see citing works
Ko, W., Rajan, P., Gomez, F., Scheinfeldt, L., An, P., Winkler, C. A., Froment, A., Nyambo, T., Omar, S. A., Wambebe, C. O., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.05.014 · Cited by 98 · see citing works
The common zoonotic protozoal diseases causing abortion
Shaapan, R. M. (2015) · Journal of Parasitic Diseases · doi:10.1007/s12639-015-0661-5 · Cited by 93 · see citing works
Sleeping Sickness Epidemics and Colonial Responses in East and Central Africa, 1900–1940
Headrick, D. R. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002772 · Cited by 91 · see citing works
Munday, J. C., Settimo, L., & de Koning, H. P. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00032 · Cited by 92 · see citing works
Biological Control of Pest and Vector Insects
Shields, V. D. C. (2017) · InTech eBooks · doi:10.5772/63274 · Cited by 87 · see citing works
An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite Interaction
Ponte‐Sucre, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02126 · Cited by 82 · see citing works
Steverding, D., Sexton, D. W., Wang, X., Gehrke, S. S., Wagner, G. K., & Caffrey, C. R. (2012) · International Journal for Parasitology · doi:10.1016/j.ijpara.2012.03.009 · Cited by 80 · see citing works
Self-citationArsenic-Based Drugs: From Fowler’s Solution to Modern Anticancer Chemotherapy
Gibaud, S., & Jaouen, G. (2010) · Topics in organometallic chemistry · doi:10.1007/978-3-642-13185-1_1 · Cited by 71 · see citing works
Extensive Admixture and Selective Pressure Across the Sahel Belt
Tříska, P., Soares, P. A., Patin, É., Fernandes, V., Černý, V., & Pereira, L. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv236 · Cited by 71 · see citing works
Anti-parasitic activity of polyether ionophores
Antoszczak, M., Steverding, D., & Huczyński, A. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.01.035 · Cited by 71 · see citing works
Self-citationThe influence of vector‐borne disease on human history: socio‐ecological mechanisms
Athni, T. S., Shocket, M. S., Couper, L., Nova, N., Caldwell, I. R., Caldwell, J. M., Childress, J. N., Childs, M. L., Leo, G. A. D., Kirk, D., et al. (2021) · Ecology Letters · doi:10.1111/ele.13675 · Cited by 72 · see citing works
Pinto, J. C., Oliveira, S., Teixeira, S., Martins, D., Fehn, A., Aço, T., Gayà‐Vidal, M., & Rocha, J. (2016) · American Journal of Physical Anthropology · doi:10.1002/ajpa.23042 · Cited by 61 · see citing works
The Long Wait for a New Drug for Human African Trypanosomiasis
Baker, C. H., & Welburn, S. C. (2018) · Trends in Parasitology · doi:10.1016/j.pt.2018.08.006 · Cited by 63 · see citing works
Schuster, S., Krüger, T., Subota, I., Thusek, S., Rotureau, B., Beilhack, A., & Engstler, M. (2017) · eLife · doi:10.7554/elife.27656 · Cited by 62 · see citing works
Late Stage Infection in Sleeping Sickness
Wolburg, H., Mogk, S., Acker, S., Frey, C., Meinert, M., Schönfeld, C., Lazarus, M., Urade, Y., Kubata, B. K., & Duszenko, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034304 · Cited by 55 · see citing works
Simwango, M., Ngonyoka, A., Nnko, H. J., Salekwa, L. P., Ole-Neselle, M., Kimera, S. I., & Gwakisa, P. S. (2017) · Parasites & Vectors · doi:10.1186/s13071-017-2411-2 · Cited by 57 · see citing works
Genetic dissection of drug resistance in trypanosomes
Alsford, S., Kelly, J. M., Baker, N., & Horn, D. (2013) · Parasitology · doi:10.1017/s003118201300022x · Cited by 54 · see citing works
Steinmann, P., Stone, C., Sutherland, C. S., Tanner, M., & Tediosi, F. (2015) · Tropical Medicine & International Health · doi:10.1111/tmi.12483 · Cited by 55 · see citing works
Tong, J., Valverde, O., Mahoudeau, C., Yun, O., & Chappuis, F. (2011) · Conflict and Health · doi:10.1186/1752-1505-5-7 · Cited by 55 · see citing works
Vincent, I. M., Daly, R., Courtioux, B., Cattanach, A. M., Biéler, S., Ndung’u, J. M., Bisser, S., & Barrett, M. P. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005140 · Cited by 54 · see citing works
Neuroinflammation and brain infections: Historical context and current perspectives
Bentivoglio, M., Mariotti, R., & Bertini, G. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.09.008 · Cited by 53 · see citing works
Mubemba, B., Mburu, M. M., Changula, K., Muleya, W., Moonga, L. C., Chambaro, H. M., Kajihara, M., Qiu, Y., Orba, Y., Hayashida, K., et al. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010193 · Cited by 51 · see citing works
Šubrtová, K., Panicucci, B., & Zı́ková, A. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004660 · Cited by 47 · see citing works
Muhanguzi, D., Picozzi, K., Hattendorf, J., Thrusfield, M. V., Welburn, S. C., Kabasa, J. D., & Waiswa, C. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003284 · Cited by 49 · see citing works
Thompson, C. K., Botero, A., Wayne, A. F., Godfrey, S. S., Lymbery, A. J., & Thompson, R. C. A. (2013) · Parasites & Vectors · doi:10.1186/1756-3305-6-121 · Cited by 49 · see citing works
Hantgan, A., Babiker, H. M. A., & List, J. (2022) · Open Research Europe · doi:10.12688/openreseurope.14339.1 · Cited by 48 · see citing works
Gibson, W. C. (2012) · Parasites & Vectors · doi:10.1186/1756-3305-5-71 · Cited by 48 · see citing works
Binding to Large Enzyme Pockets: Small‐Molecule Inhibitors of Trypanothione Reductase
Persch, E., Bryson, S., Todoroff, N. K., Eberle, C., Thelemann, J., Dirdjaja, N., Kaiser, M., Weber, M., Derbani, H., Brun, R., et al. (2014) · ChemMedChem · doi:10.1002/cmdc.201402032 · Cited by 48 · see citing works
Kansiime, F., Adibaku, S., Wamboga, C., Idi, F., Kato, C. D., Yamuah, L. K., Vaillant, M., Kioy, D. W., Olliaro, P., & Matovu, E. (2018) · Parasites & Vectors · doi:10.1186/s13071-018-2634-x · Cited by 48 · see citing works
Ebiloma, G. U., Balogun, E. O., Cueto-Diaz, E. J., de Koning, H. P., & Dardonville, C. Y. (2019) · Medicinal Research Reviews · doi:10.1002/med.21560 · Cited by 48 · see citing works
Albisetti, A., Florimond, C., Landrein, N., Vidilaseris, K., Eggenspieler, M., Lesigang, J., Dong, G., Robinson, D. R., & Bonhivers, M. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006710 · Cited by 42 · see citing works
The effect of chitosan nanospheres on the immunogenicity of Toxoplasma lysate vaccine in mice
El-Temsahy, M. M., Elkerdany, E. D., Eissa, M. M., Shalaby, T. I. A., Talaat, I. M., & Mogahed, N. M. F. H. (2014) · Journal of Parasitic Diseases · doi:10.1007/s12639-014-0546-z · Cited by 46 · see citing works
Evaluating long-term effectiveness of sleeping sickness control measures in Guinea
Pandey, A., Atkins, K. E., Bucheton, B., Camara, M., Aksoy, S., Galvani, A. P., & Ndeffo-Mbah, M. L. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-1121-x · Cited by 45 · see citing works
Brun, R., & Blum, J. A. (2012) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2012.03.003 · Cited by 45 · see citing works
The lane to the brain: how African trypanosomes invade the CNS
Mogk, S., Meiwes, A., Boßelmann, C. M., Wolburg, H., & Duszenko, M. (2014) · Trends in Parasitology · doi:10.1016/j.pt.2014.08.002 · Cited by 44 · see citing works
Liu, G., Fu, Y., Yosri, M., Chen, Y., Sun, P., Xu, J., Zhang, M., Sun, D., Strickland, A. B., Mackey, Z. B., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913443116 · Cited by 43 · see citing works
Okello, I., Mafie, E. M., Eastwood, G., Nzalawahe, J. S., & Mboera, L. E. G. (2022) · Journal of Medical Entomology · doi:10.1093/jme/tjac018 · Cited by 45 · see citing works
Biselli, R., Nisini, R., Lista, F. R., Autore, A., Lastilla, M., Lorenzo, G. D., Peragallo, M. S., Stroffolini, T., & D’Amelio, R. (2022) · Biomedicines · doi:10.3390/biomedicines10082050 · Cited by 48 · see citing works
Zur Rolle der chemischen Synthese in der Entwicklung antibakterieller Wirkstoffe
Wright, P. M., Seiple, I. B., & Myers, A. G. (2014) · Angewandte Chemie · doi:10.1002/ange.201310843 · Cited by 43 · see citing works
Pohlig, G., Bernhard, S., Blum, J. A., Burri, C., Mpanya, A., Lubaki, J.-P. F., Mpoto, A. M., Munungu, B. F., Mangoni, P., Deo, G. K. M., et al. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004363 · Cited by 43 · see citing works
Alsford, S., Field, M. C., & Horn, D. (2013) · Trends in Parasitology · doi:10.1016/j.pt.2013.03.004 · Cited by 42 · see citing works
Niosome as an Effective Nanoscale Solution for the Treatment of Microbial Infections
Barani, M., Paknia, F., Roostaee, M., Kavyani, B., Kalantar-Neyestanaki, D., Ajalli, N., & Amirbeigi, A. (2023) · BioMed Research International · doi:10.1155/2023/9933283 · Cited by 41 · see citing works
Alfituri, O. A., Quintana, J. F., MacLeod, A., Garside, P., Benson, R. A., Brewer, J. M., Mabbott, N. A., Morrison, L. J., & Capewell, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01250 · Cited by 41 · see citing works
Kaplan, B. E., Kahn, L. H., Monath, T. P. C., & Woodall, J. (2009) · Parasites & Vectors · doi:10.1186/1756-3305-2-36 · Cited by 41 · see citing works
Chtita, S., Ghamali, M., Ousaa, A., Aouidate, A., Belhassan, A., Taourati, A. I., Masand, V. H., Bouachrıne, M., & Lakhlifi, T. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01304 · Cited by 40 · see citing works
Mathematical Models of Human African Trypanosomiasis Epidemiology
Rock, K. S., Stone, C., Hastings, I. M., Keeling, M. J., Torr, S. J., & Chitnis, N. (2015) · Advances in Parasitology/Advances in parasitology · doi:10.1016/bs.apar.2014.12.003 · Cited by 39 · see citing works
Could violent conflict derail the London Declaration on NTDs?
Du, R. Y., Stanaway, J. D., & Hotez, P. J. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006136 · Cited by 39 · see citing works
MEDICAL AUXILIARIES AND THE NEGOTIATION OF PUBLIC HEALTH IN COLONIAL NORTH-WESTERN TANZANIA
Webel, M. (2013) · The Journal of African History · doi:10.1017/s0021853713000716 · Cited by 38 · see citing works
Hardwick, R. J., Ménard, A., Sironi, M., Milet, J., Garcia, A., Sese, C., Yang, F., Fu, B., Courtin, D., & Hollox, E. J. (2013) · Human Genetics · doi:10.1007/s00439-013-1352-x · Cited by 38 · see citing works
Novel lead compounds in pre-clinical development against African sleeping sickness
Berninger, M., Schmidt, I., Ponte‐Sucre, A., & Holzgrabe, U. (2017) · MedChemComm · doi:10.1039/c7md00280g · Cited by 38 · see citing works
An atlas of tsetse and animal African trypanosomiasis in Zimbabwe
Shereni, W., Neves, L., Argilés-Herrero, R., Nyakupinda, L., & Cecchi, G. (2021) · Parasites & Vectors · doi:10.1186/s13071-020-04555-8 · Cited by 38 · see citing works
Mekonnen, Y. A., Gültas, M., Effa, K., Hanotte, O., & Schmitt, A. O. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01095 · Cited by 37 · see citing works
“In previous studies, trypanotolerant animals were reported to switch from innate immune response to adaptive immune response with the induction of active macrophages (M2) following trypanosome infection (Stijlemans et al., 2010; Bosschaerts et al., 2011).”
BackgroundA review on potential therapeutic targets for the treatment of leishmaniasis
Sheikh, S. Y., Hassan, F., Shukla, D., Bala, S., Faruqui, T., Akhter, Y., Khan, A. R., & Nasibullah, M. (2024) · Parasitology International · doi:10.1016/j.parint.2024.102863 · Cited by 36 · see citing works
Campbell, Z. A., Coleman, P., Guest, A., Kushwaha, P., Ramuthivheli, T., Osebe, T., Perry, B. D., & Salt, J. S. (2021) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2021.105279 · Cited by 36 · see citing works
The spreading of parasites by human migratory activities
Steverding, D. (2020) · Virulence · doi:10.1080/21505594.2020.1809963 · Cited by 35 · see citing works
Self-citationStijlemans, B., Vankrunkelsven, A., Caljon, G., Bockstal, V., Guilliams, M., Bosschaerts, T., Beschin, A., Raes, G., Magez, S., & Baetselier, P. (2010) · Endocrine, Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153010790827966 · Cited by 35 · see citing works
Trypanosomes as a magnifying glass for cell and molecular biology
Lukeš, J., Speijer, D., Zı́ková, A., Alfonzo, J. D., Hashimi, H., & Field, M. C. (2023) · Trends in Parasitology · doi:10.1016/j.pt.2023.08.004 · Cited by 38 · see citing works
Bovine trypanosomosis and vector density in Omo-Ghibe tsetse belt, South Ethiopia
Abebe, R., Gute, S., & Simon, I. (2016) · Acta Tropica · doi:10.1016/j.actatropica.2016.12.016 · Cited by 34 · see citing works
Sleep medicine in Africa: past, present, and future
Komolafe, M. A., Sanusi, A. A., Idowu, A. O., Balogun, S. A., Olorunmonteni, O. E., Adebowale, A., Fawale, B., & Mosaku, K. S. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9218 · Cited by 34 · see citing works
Ortiz-Martínez, Y., Kouamé, M. G., Bongomin, F., Lakoh, S., & Henao‐Martínez, A. F. (2023) · Current Tropical Medicine Reports · doi:10.1007/s40475-023-00304-w · Cited by 32 · see citing works
Sleeping Sickness and Nagana Disease Caused by Trypanosoma brucei
Steverding, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-13884-8_18 · Cited by 32 · see citing works
Self-citationShereni, W., Anderson, N. E., Nyakupinda, L., & Cecchi, G. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1879-5 · Cited by 32 · see citing works
Degneh, E., Shibeshi, W., Terefe, G., Asres, K., & Ashenafi, H. (2017) · Acta veterinaria Scandinavica · doi:10.1186/s13028-017-0327-7 · Cited by 32 · see citing works
Coley, A. F., Dodson, H., Morris, M. T., & Morris, J. C. (2011) · Molecular Biology International · doi:10.4061/2011/123702 · Cited by 32 · see citing works
Murray, K. A., Allen, T., Loh, E. H., Machalaba, C. C., & Daszak, P. (2015) · Springer eBooks · doi:10.1007/978-3-319-24442-6_2 · Cited by 34 · see citing works
Kelly, S. L., Ivens, A. C., Mott, G. A., O’Neill, E. C., Emms, D., Macleod, O. J. S., Voorheis, H. P., Tyler, K. M., Clark, M. D., Matthews, J. B., et al. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx152 · Cited by 32 · see citing works
Development and Introduction of Fexinidazole into the Global Human African Trypanosomiasis Program
Mordt, O. V., Tarral, A., & Wourgaft, N. S. (2022) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.21-1176 · Cited by 31 · see citing works
Interferon Gamma in African Trypanosome Infections: Friends or Foes?
Wu, H., Liu, G., & Shi, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01105 · Cited by 31 · see citing works
Tackling Sleeping Sickness: Current and Promising Therapeutics and Treatment Strategies
Jamabo, M., Mahlalela, M. E., Edkins, A. L., & Boshoff, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512529 · Cited by 33 · see citing works
The trypanothione system and its implications in the therapy of trypanosomatid diseases
Flohé, L. (2012) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2012.07.008 · Cited by 31 · see citing works
Jha, B. A., Gazestani, V., Yip, C. W., & Salavati, R. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.036 · Cited by 30 · see citing works
Village-scale persistence and elimination of gambiense human African trypanosomiasis
Davis, C. N., Rock, K. S., Miaka, E. M., & Keeling, M. J. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007838 · Cited by 26 · see citing works
Mulandane, F. C., Snyman, L. P., Brito, D. R. A., Bouyer, J., Fafetine, J. M., Abbeele, J. V. D., Oosthuizen, M. C., Delespaux, V., & Neves, L. (2020) · Parasites & Vectors · doi:10.1186/s13071-020-04087-1 · Cited by 29 · see citing works
Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1
Currier, R. B., Cooper, A., Burrell‐Saward, H., MacLeod, A., & Alsford, S. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006855 · Cited by 29 · see citing works
Liu, G., Xu, J., Wu, H., Sun, D., Zhang, X., Zhu, X., Magez, S., & Shi, M. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005065 · Cited by 28 · see citing works
Fajinmi, A. O., Faleke, O. O., Magaji, A. A., Daneji, A. I., & Gweba, M. (2011) · Research Journal of Parasitology · doi:10.3923/jp.2011.31.42 · Cited by 28 · see citing works
Computational approaches for drug discovery against trypanosomatid-caused diseases
Pereira, C. A., Sayé, M., Reigada, C., Silber, A. M., Labadié, G. R., Miranda, M. R., & Valera-Vera, E. A. (2020) · Parasitology · doi:10.1017/s0031182020000207 · Cited by 28 · see citing works
- Authors
- Steverding, D.
- Affiliations
- University of East Anglia (GB)
- Corresponding author
- Steverding, Dietmar
- ORCID
- Steverding, Dietmar
- Venue
- Parasites & Vectors
- Published
- 2008
- Volume
- 1
- Issue
- 1
- Pages
- 3
- ISSN
- 1756-3305 (ISSN-L)
- PMC
- PMC2270819
- OpenAlex
- W2117650737
- Cited by
- 470
- References
- 38
- Citations by year
- 2026: 15 · 2025: 31 · 2024: 39 · 2023: 25 · 2022: 33 · 2021: 40 · 2020: 39 · 2019: 21 · 2018: 36 · 2017: 27 · 2016: 26 · 2015: 24 · 2014: 33 · 2013: 30 · 2012: 19
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Parasites & Vectors (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Social Sciences › Arts and Humanities › History › History of Medicine and Tropical Health
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
- Keywords
- sleeping sickness, history of medicine, hominid evolution, disease transmission, trypanosome identification, antitrypanosomal drugs, disease control, sub-Saharan Africa
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