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Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

Wlaschin, J. J., Gluski, J. M., Nguyen, E. K., Silberberg, H., Thompson, J. H., Chesler, A. T., & Pichon, C. E. L. (2018) · eLife · doi:10.7554/elife.33910 · Cited by 64 · see citing works

Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration

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Intrinsic Neuronal Stress Response Pathways in Injury and Disease

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Multitasking: Dual Leucine Zipper–Bearing Kinases in Neuronal Development and Stress Management

Jin, Y., & Zheng, B. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062644 · Cited by 47 · see citing works

Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

Li, J., Zhang, Y. V., Adib, E. A., Stanchev, D., Xiong, X., Klinedinst, S., Soppina, P., Jahn, T. R., Hume, R. I., Rasse, T. M., et al. (2017) · eLife · doi:10.7554/elife.24271 · Cited by 44 · see citing works

Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17

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RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function

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The Molecular Interplay between Axon Degeneration and Regeneration

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Therapeutic opportunities and pitfalls in the treatment of axon degeneration

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DLK mediates the neuronal intrinsic immune response and regulates glial reaction and neuropathic pain

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Integrated stress response inhibition provides sex-dependent protection against noise-induced cochlear synaptopathy

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Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration

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The response of Dual-leucine zipper kinase (DLK) to nocodazole: Evidence for a homeostatic cytoskeletal repair mechanism

DeVault, L., Mateusiak, C., Palucki, J., Brent, M. R., Milbrandt, J., & DiAntonio, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300539 · Cited by 19 · see citing works

Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury

Kingston, R., Amin, D., Misra, S., Gross, J. M., & Kuwajima, T. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009885 · Cited by 19 · see citing works

Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions

Goodwani, S., Fernandez, C., Acton, P. J., Buggia-Prévot, V., McReynolds, M. L., Ma, J., Hu, C. H., Hamby, M. E., Jiang, Y., Le, K., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144849 · Cited by 18 · see citing works

DLK-dependent axonal mitochondrial fission drives degeneration after axotomy

Gómez-Deza, J., Nebiyou, M., Alkaslasi, M. R., Nadal-Nicolás, F. M., Somasundaram, P., Slavutsky, A. L., Li, W., Ward, M. E., Watkins, T. A., & Pichon, C. E. L. (2024) · Nature Communications · doi:10.1038/s41467-024-54982-9 · Cited by 16 · see citing works

The transcriptional response of cortical neurons to concussion reveals divergent fates after injury

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DLK signaling in axotomized neurons triggers complement activation and loss of upstream synapses

Adib, E. A., Shadrach, J. L., Reilly-Jankowiak, L., Dwivedi, M. K., Rogers, A. E., Shahzad, S., Passino, R., Giger, R. J., Pierchala, B. A., & Collins, C. A. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113801 · Cited by 14 · see citing works

FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury

Lee, B., Oh, Y., Cho, E., DiAntonio, A., Cavalli, V., Shin, J. E., Choi, H. W., & Cho, Y. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101647 · Cited by 14 · see citing works

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

Yulyaningsih, E., Suh, J. H., Fanok, M., Chau, R., Solanoy, H., Takahashi, R., Bakardjiev, A., Becerra, I., Benitez, N. B., Chiu, C.-L., et al. (2024) · eLife · doi:10.7554/elife.92173 · Cited by 9 · see citing works

CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neuronsPreprint

Tian, R., Gachechiladze, M. A., Ludwig, C., Laurie, M. T., Hong, J. Y., Nathaniel, D., Prabhu, A. V., Fernandopulle, M. S., Patel, R., Abshari, M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/513309 · Cited by 12 · see citing works

Rab11 suppresses neuronal stress signaling by localizing dual leucine zipper kinase to axon terminals for protein turnover

Kim, S., Quagraine, Y., Singh, M., & Kim, J. H. (2024) · eLife · doi:10.7554/elife.96592.3 · Cited by 9 · see citing works

Regulation of the Activity of the Dual Leucine Zipper Kinase by Distinct Mechanisms

Köster, K.-A., Dethlefs, M., Escobar, J. D., & Oetjen, E. (2024) · Cells · doi:10.3390/cells13040333 · Cited by 8 · see citing works

Neuronal Dual Leucine Zipper Kinase Mediates Inflammatory and Nociceptive Responses in Cyclophosphamide-Induced Cystitis

Jiang, C., Fang, W., Lv, T., Gu, Y., & Lv, J. (2021) · Journal of Innate Immunity · doi:10.1159/000514545 · Cited by 8 · see citing works

Regulation of degenerative spheroids after injury

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Expression of a novel versican variant in dorsal root ganglia from spared nerve injury rats

Bogen, O., Bender, O., Álvarez, P., Kern, M., Tomiuk, S., Hucho, F., & Levine, J. D. (2019) · Molecular Pain · doi:10.1177/1744806919874557 · Cited by 7 · see citing works

Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injury

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Dual Leucine Zipper Kinase Regulates Dscam Expression through a Noncanonical Function of the Cytoplasmic Poly(A)-Binding Protein

Singh, M., Ye, B., & Kim, J. H. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0543-21.2022 · Cited by 6 · see citing works

Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Wang, X., Li, W., Zhang, J., Li, J., Zhang, X., Wang, M., Wei, Z., & Feng, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04375-1 · Cited by 6 · see citing works

Chronic integrated stress response causes dysregulated cholesterol synthesis in white matter disease

Lin, K., Ly, N., Kunjamma, R. B., Vu, N., King, B., Robb, H. M., Mohler, E. G., Sridar, J., Hao, Q., Zavala‐Solorio, J., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.188459 · Cited by 6 · see citing works

APP Genetic Deficiency Alters Intracellular Ca2+ Homeostasis and Delays Axonal Degeneration in Dorsal Root Ganglion Sensory Neurons

de León, A., Gibon, J., & Barker, P. A. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0162-22.2022 · Cited by 5 · see citing works

Systematic identification of potential key microRNAs and circRNAs in the dorsal root ganglia of mice with sciatic nerve injury

Yu, Y., Xu, X., Lin, C., & Liu, R. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1119164 · Cited by 5 · see citing works

PDK1 is a negative regulator of axon regeneration

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Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degenerationPreprint

Ritchie, E. M., Acar, D., Zhong, S., Pu, Q., Li, Y., Zheng, B., & Jin, Y. (2024) · eLife · doi:10.7554/elife.101173 · Cited by 6 · see citing works

Regulation of dual leucine zipper kinase activity through its interaction with calcineurin

Escobar, J. D., Kutschenko, A., Schröder, S., Blume, R., Köster, K.-A., Painer, C., Lemcke, T., Maison, W., & Oetjen, E. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109953 · Cited by 4 · see citing works

DLK, NMNAT2, and SARM1: Judge, Jury, and Executioner in Axon Degeneration

Hinz, F. I., & Hoogenraad, C. C. (2026) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-051424-045840 · Cited by 3 · see citing works

Discovery of novel immunotherapeutic drug candidates for sciatic nerve injury using bioinformatic analysis and experimental verification

Li, S., Yu, B., Gao, X., Zheng, Y., Ma, T., Hao, Y., Wu, H., Wei, B., Wei, Y., Luo, Z., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1035143 · Cited by 3 · see citing works

ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis

Gómez-Deza, J., Nebiyou, M., Touny, L. H. E., Alkaslasi, M. R., Zuo, Z., Wlaschin, J. J., Nadal-Nicolás, F. M., Stavsky, A., Zhang, X., Slavutsky, A. L., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.04.035 · Cited by 3 · see citing works

Computer-Aided Multi-Target Management of Emergent Alzheimer’s Disease

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Modeling Alzheimer’s disease in primary neurons reveals DNA damage response coupled with MAPK-DLK signaling in wild-type tau-induced neurodegenerationPreprint

Li, S., Roy, E. R., Wang, Y., Watkins, T. A., & Cao, W. (2023) · Research Square · doi:10.21203/rs.3.rs-2617457/v1 · Cited by 3 · see citing works

Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS

Bekier, M. E., Pinarbasi, E., Krishnan, G., Mesojedec, J. J., Hurley, M., Harikumar Sheela, H., Collins, C. A., Ghaffari, L., de Majo, M., Ullian, E. M., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci188138 · Cited by 2 · see citing works

Context Specificity of MAP3K DLK Signaling in the Nervous System: Insights from Genetics and Genomics

Ritchie, E. M., & Jin, Y. (2025) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102103 · Cited by 2 · see citing works

MKK4 and MKK7 control degeneration of retinal ganglion cell somas and axons after glaucoma-relevant injury

Marola, O. J., Syc‐Mazurek, S. B., Yablonski, S. E. R., Shrager, P. G., John, S. W. M., & Libby, R. T. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02842-w · Cited by 2 · see citing works

Protein kinases as therapeutic targets in Alzheimer’s disease: challenges, insights, and new frontiers

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Increase of c-FOS promoter transcriptional activity by the dual leucine zipper kinase

Köster, K.-A., Escobar, J. D., Fietkau, A., Toledo, R., & Oetjen, E. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02401-z · Cited by 2 · see citing works

Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by Atf4 following optic nerve injuryPreprint

Somasundaram, P., Farley, M. M., Rudy, M. A., Stefanoff, D. G., Shah, M., Goli, P. S., Heo, J., Wang, S., Tran, N. M., & Watkins, T. A. (2023) · eLife · doi:10.7554/elife.87528.1 · Cited by 2 · see citing works

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress ResponsePreprint

Yulyaningsih, E., Suh, J. H., Fanok, M. H., Chau, R., Solanoy, H. O., Takahashi, R., Bakardjiev, A. I., Becerra, I. A., Benitez, N. B., Chiu, C., et al. (2023) · eLife · doi:10.7554/elife.92173.1 · Cited by 2 · see citing works

Rab11 suppresses neuronal stress signaling by localizing dual leucine zipper kinase to axon terminals for protein turnoverPreprint

Kim, S., Quagraine, Y., Singh, M., & Kim, J. H. (2024) · eLife · doi:10.7554/elife.96592 · Cited by 2 · see citing works

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress ResponsePreprint

Yulyaningsih, E., Suh, J. H., Fanok, M. H., Chau, R., Solanoy, H. O., Takahashi, R., Bakardjiev, A. I., Becerra, I. A., Benitez, N. B., Chiu, C., et al. (2024) · eLife · doi:10.7554/elife.92173.2 · Cited by 2 · see citing works

Optogenetic Control of the Integrated Stress Response Limits Glioblastoma Invasion

Månsson, L. K., Dickson, E., Li, H., Pitenis, A. A., & Wilson, M. Z. (2026) · Cell Biochemistry and Function · doi:10.1002/cbf.70212 · Cited by 1 · see citing works

Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injuryPreprint

Somasundaram, P., Farley, M. M., Rudy, M. A., Sigal, K., Asencor, A. I., Stefanoff, D. G., Shah, M., Goli, P. S., Heo, J., Wang, S., et al. (2023) · eLife · doi:10.7554/elife.87528 · Cited by 1 · see citing works

DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress ResponsePreprint

Yulyaningsih, E., Suh, J. H., Fanok, M. H., Chau, R., Solanoy, H., Takahashi, R. H., Bakardjiev, A., Becerra, I., Benitez, N. B., Chiu, C.-L., et al. (2024) · bioRxiv · doi:10.1101/2023.08.21.554203 · Cited by 4 · see citing works

Rab11 suppresses neuronal stress signaling by localizing Dual leucine zipper kinase to axon terminals for protein turnoverPreprint

Kim, S., Quagraine, Y., Singh, M., & Kim, J. H. (2024) · eLife · doi:10.7554/elife.96592.1 · Cited by 1 · see citing works

Coordinated stimulation of axon regenerative and neurodegenerative transcriptional programs by ATF4 following optic nerve injuryPreprint

Somasundaram, P., Farley, M. M., Rudy, M. A., Sigal, K., Asencor, A. I., Stefanoff, D. G., Shah, M., Goli, P. S., Heo, J., Wang, S., et al. (2024) · eLife · doi:10.7554/elife.87528.2 · Cited by 1 · see citing works

FKBPL and FKBP8 regulate DLK degradation and neuronal responses to axon injuryPreprint

Lee, B., Oh, Y., Cho, E., DiAntonio, A., Cavalli, V., Shin, J. E., & Cho, Y. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.20.457064

Effect of Dual Leucine Zipper Kinase Inhibitor GNE-3511 on Epileptogenesis and Cognitive and Behavioral Changes in a Temporal Lobe Epilepsy Model in MicePreprint

Acar, D., Tunçcan, E., Selek, S. N., Sayın, İ. E., Aşaroğlu, C. B., Tümentemur, G., Arslan, D. Ö., Özdemir, S., & Süyen, G. G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.11.544443

Targeting eIF2α in TBI-induced traumatic optic neuropathy: Effects of Salubrinal and the Integrated Stress Response InhibitorPreprint

Hetzer, S., Bellary, R., Torrens, J. N., Grimaldi, R., & Evanson, N. (2024) · bioRxiv · doi:10.1101/2024.02.15.580435

A lead role for a “secondary” axonal injury response

Rudy, M. A., & Watkins, T. A. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-02070

Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

Ritchie, E. M., Acar, D., Zhong, S., Pu, Q., Li, Y., Zheng, B., & Jin, Y. (2025) · eLife · doi:10.1101/2024.07.10.602846

Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degenerationPreprint

Ritchie, E. M., Zhong, S., Pu, Q., Li, Y., Zheng, B., & Jin, Y. (2024) · eLife · doi:10.7554/elife.101173.1

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

Yulyaningsih, E., Suh, J. H., Fanok, M. H., Chau, R., Solanoy, H. O., Takahashi, R., Bakardjiev, A. I., Becerra, I. A., Benitez, N. B., Chiu, C., et al. (2024) · eLife · doi:10.7554/elife.92173.3

Rab11 suppresses neuronal stress signaling by localizing Dual leucine zipper kinase to axon terminals for protein turnoverPreprint

Kim, S., Quagraine, Y., Singh, M., & Kim, J. H. (2024) · eLife · doi:10.7554/elife.96592.2

Chemogenetic neuronal silencing decouples c‐Jun activation from cell death in the temporal cortex

Wood, C. A., Somasundaram, P., Dundee, J. M., Rudy, M. A., Watkins, T. A., & Jankowsky, J. L. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16575

Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degenerationPreprint

Ritchie, E. M., Acar, D., Zhong, S., Pu, Q., Li, Y., Zheng, B., & Jin, Y. (2025) · eLife · doi:10.7554/elife.101173.2

Additional file 6 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Wang, X., Li, W., Zhang, J., Li, J., Zhang, X., Wang, M., Wei, Z., & Feng, S. (2024) · Figshare · doi:10.6084/m9.figshare.26607247

Additional file 4 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Wang, X., Li, W., Zhang, J., Li, J., Zhang, X., Wang, M., Wei, Z., & Feng, S. (2024) · Figshare · doi:10.6084/m9.figshare.26607241

Additional file 2 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Wang, X., Li, W., Zhang, J., Li, J., Zhang, X., Wang, M., Wei, Z., & Feng, S. (2024) · Figshare · doi:10.6084/m9.figshare.26607235

Additional file 5 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Wang, X., Li, W., Zhang, J., Li, J., Zhang, X., Wang, M., Wei, Z., & Feng, S. (2024) · Figshare · doi:10.6084/m9.figshare.26607244

Additional file 8 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Wang, X., Li, W., Zhang, J., Li, J., Zhang, X., Wang, M., Wei, Z., & Feng, S. (2024) · Figshare · doi:10.6084/m9.figshare.26607253

Additional file 3 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Wang, X., Li, W., Zhang, J., Li, J., Zhang, X., Wang, M., Wei, Z., & Feng, S. (2024) · Figshare · doi:10.6084/m9.figshare.26607238

Additional file 1 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Wang, X., Li, W., Zhang, J., Li, J., Zhang, X., Wang, M., Wei, Z., & Feng, S. (2024) · Figshare · doi:10.6084/m9.figshare.26607232

Additional file 7 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion

Wang, X., Li, W., Zhang, J., Li, J., Zhang, X., Wang, M., Wei, Z., & Feng, S. (2024) · Figshare · doi:10.6084/m9.figshare.26607250

DNL343 and Disease Progression in Amyotrophic Lateral Sclerosis

Paganoni, S., Chibnik, L. B., Quintana, M., Macklin, E. A., Detry, M. A., Vestrucci, M., Paulon, G., McGlothlin, A., Wang, J., Walk, D., et al. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.34809

Single-cell transcriptomics reveals reversible microglia/macrophage activation after human retinal neuron transplantation into mouse retina

Kriukov, E., Mukwaya, A., Cullen, P., Kam, H. T., Baldwin, G., Malechka, V. V., Refaian, N., Bagaev, N., Labrecque, E., Vinjamuri, S., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117232 · Cited by 4 · see citing works

BindingDB Entry 50002444: Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration.

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BindingDB Entry 50001176: Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

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The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons

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Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

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DLK zips across neurodegeneration

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Dual Leucine Zipper Kinase (DLK) Constitutively Signals in the Uninjured Mouse Cerebellum

Goodwani, S., Acton, P. J., Buggia-Prévot, V., Chakraborty, C., Hamby, M. E., Lightfoot, Y. L., McReynolds, M. L., Al‐Ouran, R., Soth, M., JONES, P. G., et al. (2018) · The FASEB Journal · doi:10.1096/fasebj.2018.32.1_supplement.687.11

Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions

Goodwani, S., Fernandez, C., Acton, P. J., Buggia-Prévot, V., McReynolds, M. L., Ma, J., Hu, C. H., Hamby, M. E., Jiang, Y., Le, K., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144849 · Cited by 18 · see citing works