The integrated stress response: From mechanism to disease

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Memory - A century of consolidation

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The molecular biology of memory storage: a dialogue between genes and synapses

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Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

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Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

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Perk is essential for translational regulation and cell survival during the unfolded protein response

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulumPreprint

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Reinitiation involving upstream ORFs regulates <i>ATF4</i> mRNA translation in mammalian cells

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The proteostasis network and its decline in ageing

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Protein synthesis and memory: A review.

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The Biology of Proteostasis in Aging and Disease

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CREB AND MEMORY

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A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress

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Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

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Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

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TRANSLATIONAL REGULATION OFGCN4AND THE GENERAL AMINO ACID CONTROL OF YEAST

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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

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Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

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Translational control by 5′-untranslated regions of eukaryotic mRNAs

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Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

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Engineering a memory with LTD and LTP

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Translational control of long-lasting synaptic plasticity and memory

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Dendritic Protein Synthesis, Synaptic Plasticity, and Memory

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EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

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Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

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Novel role of PKR in inflammasome activation and HMGB1 release

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Upstream Open Reading Frames as Regulators of mRNA Translation

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Pharmacological brake-release of mRNA translation enhances cognitive memory

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The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

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The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

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Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

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Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2

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The dsRNA protein kinase PKR: Virus and cell control

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Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase.

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Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1 H -indol-5-yl)-7 H -pyrrolo[2,3- d ]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

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Sustained translational repression by eIF2α-P mediates prion neurodegeneration

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The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

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Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

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Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

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Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

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Role of eIF2α Kinases in Translational Control and Adaptation to Cellular StressPreprint

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Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

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Activation of the unfolded protein response in Parkinson’s disease

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eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory

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Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

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EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension

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Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to Enhance CHOP Translation

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ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

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Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit

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Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

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Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2

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UPR proteins IRE1 and PERK switch BiP from chaperone to ER stress sensor

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TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

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Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter

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Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

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A new leukoencephalopathy with vanishing white matter

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Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter

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Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

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Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

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Translational control in synaptic plasticity and cognitive dysfunction

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Making synaptic plasticity and memory last: mechanisms of translational regulationPreprint

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Inhibition of a constitutive translation initiation factor 2α phosphatase, CReP , promotes survival of stressed cells

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Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex

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Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production

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Phosphorylation of eIF2 Directs ATF5 Translational Control in Response to Diverse Stress Conditions

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Phosphorylation of the α-Subunit of the Eukaryotic Initiation Factor-2 (eIF2α) Reduces Protein Synthesis and Enhances Apoptosis in Response to Proteasome Inhibition

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Translational Control in CancerPreprint

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PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

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PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

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Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimerʼs disease

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Abrogation of translation initiation factor eIF‐2 phosphorylation causes malignant transformation of NIH 3T3 cells.

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Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

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PERK EIF2AK3 control of pancreatic β cell differentiation and proliferation is required for postnatal glucose homeostasis

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Down syndrome: the brain in trisomic mode

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ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

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Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2α) dephosphorylation in mammalian development

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