The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity
Open accessAbstract
T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We characterize herein how human primary CD4+ T cell functions are affected by stiffness within the physiological Young’s modulus range of 0.5 kPa to 100 kPa. Stiffness modulates T lymphocyte migration and morphological changes induced by TCR/CD3 triggering. Stiffness also increases TCR-induced immune system, metabolism and cell-cycle-related genes. Yet, upon TCR/CD3 stimulation, while cytokine production increases within a wide range of stiffness, from hundreds of Pa to hundreds of kPa, T cell metabolic properties and cell cycle progression are only increased by the highest stiffness tested (100 kPa). Finally, mechanical properties of adherent antigen-presenting cells modulate cytokine production by T cells. Together, these results reveal that T cells discriminate between the wide range of stiffness values found in the body and adapt their responses accordingly.
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Metadata
- Authors
- Saitakis, M., Dogniaux, S., Goudot, C., Bufi, N., Asnacios, S., Maurin, M., Randriamampita, C., Asnacios, A., & Hivroz, C.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2017-06-08
- Volume
- 6
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2622883680
- Cited by
- 257
- References
- 111
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- gold
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- Saitakis, M., Dogniaux, S., Goudot, C., Bufi, N., Asnacios, S., Maurin, M., Randriamampita, C., Asnacios, A., & Hivroz, C. (2017). Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity. eLife. https://doi.org/10.7554/elife.23190
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