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Cited by 70Neurobiology and Insect Physiology ResearchMotor Control and AdaptationNeuroscience and Neuropharmacology Research

Simultaneous activation of parallel sensory pathways promotes a grooming sequence in Drosophila

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Hampel, Stefanie, McKellar, Claire E, Simpson, Julie H, Seeds, Andrew M·2017·eLife
DOI 10.7554/elife.28804PMC PMC5614557

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Abstract

A central model that describes how behavioral sequences are produced features a neural architecture that readies different movements simultaneously, and a mechanism where prioritized suppression between the movements determines their sequential performance. We previously described a model whereby suppression drives a Drosophila grooming sequence that is induced by simultaneous activation of different sensory pathways that each elicit a distinct movement (Seeds et al., 2014). Here, we confirm this model using transgenic expression to identify and optogenetically activate sensory neurons that elicit specific grooming movements. Simultaneous activation of different sensory pathways elicits a grooming sequence that resembles the naturally induced sequence. Moreover, the sequence proceeds after the sensory excitation is terminated, indicating that a persistent trace of this excitation induces the next grooming movement once the previous one is performed. This reveals a mechanism whereby parallel sensory inputs can be integrated and stored to elicit a delayed and sequential grooming response.

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  • Computational activation of mechanosensory neurons predicts activation of a small set of neurons comprising the antennal grooming circuit, and accurately describes the circuit response upon activation of different mechanosensory subtypes.

    “Additionally, we applied this model to mechanosensory circuits and found that computational activation of mechanosensory neurons predicts activation of a small set of neurons comprising the antennal grooming circuit, and accurately describes the circuit response upon activation of different mechanosensory subtypes6–10.”

    From A Drosophila computational brain model reveals sensorimotor processing (2024) · cites this paper as [9]

    The Results section, “Identification of mechanosensory neurons that elicit specific grooming movements” (page unavailable), reports that activating identified mechanosensory neurons elicits eye or wing grooming. The paper does not report computational activation predicting a small set of antennal-grooming circuit neurons or accurately describing responses to different mechanosensory subtypes; the citing sentence presents those as its authors’ own findings. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • The antennal grooming circuit has well-defined sensory inputs and a discrete, easily quantified behavioural output: antennal grooming behaviour.

    “As with the feeding initiation circuit, the antennal grooming circuit has well-defined sensory inputs, and a discrete, easily quantified behavioural output: antennal grooming behaviour.”

    From A Drosophila computational brain model reveals sensorimotor processing (2024) · cites this paper as [9]

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Cited by

Sorted by citations

Authors
Hampel, S., McKellar, C. E., Simpson, J. H., & Seeds, A. M.
Affiliations
Howard Hughes Medical Institute (US)
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2017-09-09
Volume
6
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.28804
PMC
PMC5614557
OpenAlex
W2614463946
Cited by
70
References
4
Citations by year
2026: 8 · 2025: 11 · 2024: 12 · 2023: 11 · 2022: 4 · 2021: 5 · 2020: 15 · 2019: 2 · 2018: 2
FWCI
2.54
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health (GM103642, MD007600)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
grooming, behavioral sequences, parallel sensory pathways, movement suppression, sensory integration, Drosophila, optogenetic stimulation, transgene expression
MeSH terms
Afferent Pathways, Animals, Drosophila melanogaster, Grooming, Sensory Receptor Cells, Animals, Genetically Modified, Optogenetics

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