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Metabolism in the Zebrafish Retina

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Progressive Dysmorphia of Retinal Pigment Epithelium in Age-Related Macular Degeneration Investigated by Fluorescence Lifetime Imaging

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Ambra1haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration

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Reprogramming the metabolome rescues retinal degeneration

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Programmed Non-Apoptotic Cell Death in Hereditary Retinal Degeneration: Crosstalk between cGMP-Dependent Pathways and PARthanatos?

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Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons

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Metformin and risk of age-related macular degeneration in individuals with type 2 diabetes: a retrospective cohort study

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The Protective Role of Microglial PPARα in Diabetic Retinal Neurodegeneration and Neurovascular Dysfunction

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TIN2 modulates FOXO1 mitochondrial shuttling to enhance oxidative stress-induced apoptosis in retinal pigment epithelium under hyperglycemia

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Systemic Treatment With Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration

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Metabolism in Retinopathy of Prematurity

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Association between metformin use and the risk of age-related macular degeneration in patients with type 2 diabetes: a retrospective study

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Testing Mitochondrial-Targeted Drugs in iPSC-RPE from Patients with Age-Related Macular Degeneration

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Transcriptomic and Chromatin Accessibility Analysis of the Human Macular and Peripheral Retinal Pigment Epithelium at the Single-Cell Level

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Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina

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Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy

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Bioenergetic shift and actin cytoskeleton remodelling as acute vascular adaptive mechanisms to angiotensin II in murine retina and ophthalmic artery

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Peroxisomal Disorders and Their Mouse Models Point to Essential Roles of Peroxisomes for Retinal Integrity

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Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study

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Neuroprotective and vision‐protective effect of preserving ATP levels by AMPK activator

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Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection

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Multimodal single-cell analysis of nonrandom heteroplasmy distribution in human retinal mitochondrial disease

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Polyunsaturated Lipids in the Light-Exposed and Prooxidant Retinal Environment

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Epigenome–metabolism nexus in the retina: implications for aging and disease

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Deficient RPE mitochondrial energetics leads to subretinal fibrosis in age-related neovascular macular degeneration

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Precision metabolome reprogramming for imprecision therapeutics in retinitis pigmentosa

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The Opto-Respiratory Compromise: Balancing Oxygen Supply and Light Transmittance in the Retina

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The dentate gyrus differentially metabolizes glucose and alternative fuels during rest and stimulation

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Geographic atrophy: pathophysiology and current therapeutic strategies

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Effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health

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A Mathematical Analysis of Aerobic Glycolysis Triggered by Glucose Uptake in Cones

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An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice

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Neural and Müller glial adaptation of the retina to photoreceptor degeneration

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Imaging of lactate metabolism in retinal Müller cells with a FRET nanosensor

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Power to see—Drivers of aerobic glycolysis in the mammalian retina: A review

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A Splice Variant in SLC16A8 Gene Leads to Lactate Transport Deficit in Human iPS Cell-Derived Retinal Pigment Epithelial Cells

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Duloxetine protects against experimental diabetic retinopathy in mice through retinal GFAP downregulation and modulation of neurotrophic factors

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Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells

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Mitochondrial Dysfunction as a Novel Target for Neuroprotective Nutraceuticals in Ocular Diseases

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Variability in Retinal Neuron Populations and Associated Variations in Mass Transport Systems of the Retina in Health and Aging

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Homeostasis and dyshomeostasis of the retina

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PKM2 ablation enhanced retinal function and survival in a preclinical model of retinitis pigmentosa

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Modelling neurodegeneration and inflammation in early diabetic retinopathy using 3D human retinal organoids

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Does senescence play a role in age-related macular degeneration?

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Warburg Effect as a Novel Mechanism for Homocysteine-Induced Features of Age-Related Macular Degeneration

Samra, Y. A., Zaidi, Y., Rajpurohit, P., Raghavan, R., Cai, L., Kaddour‐Djebbar, I., & Tawfik, A. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021071 · Cited by 18

Tunicamycin-induced photoreceptor atrophy precedes degeneration of retinal capillaries with minimal effects on retinal ganglion and pigment epithelium cells

Wang, S., Liu, Y., Tan, J. W., Hu, T., Zhang, H. F., Sorenson, C. M., Smith, J. A., & Sheibani, N. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107756 · Cited by 18

Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration

Fu, Z., Qiu, C., Cagnone, G., Tomita, Y., Huang, S., Cakir, B., Kotoda, Y., Allen, W., Bull, E., Akula, J. D., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102376 · Cited by 19

Mitochondria: The Retina’s Achilles’ Heel in AMD

Ferrington, D. A., Kenney, M. C., Atilano, S. R., Hurley, J. B., Brown, E. E., & Ash, J. D. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-66014-7_10 · Cited by 18

Dimethyl Fumarate Blocks Tumor Necrosis Factor-Alpha-Driven Inflammation and Metabolic Rewiring in the Retinal Pigment Epithelium

Shu, D. Y., Frank, S., Fitch, T. C., Karg, M. M., Butcher, E. R., Nnuji-John, E., Kim, L. A., & Saint‐Geniez, M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.896786 · Cited by 18

The circadian clock regulates RPE-mediated lactate transport via SLC16A1 (MCT1)

Milićević, N., ten Brink, J. B., ten Asbroek, A. L. M. A., Bergen, A. A. B., & Felder‐Schmittbuhl, M. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107861 · Cited by 18

A Modified Arrestin1 Increases Lactate Production in the Retina and Slows Retinal Degeneration

Nelson, T. S., Simpson, C. P., Dyka, F. M., Dinculescu, A., & Smith, W. C. (2022) · Human Gene Therapy · doi:10.1089/hum.2021.272 · Cited by 17

Analysis of mitochondrial dynamics and function in the retinal pigment epithelium by high-speed high-resolution live imaging

Tan, L. X., Li, J., Germer, C. J., & Lakkaraju, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1044672 · Cited by 17

Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration

Hansman, D., Ma, Y., Thomas, D., Smith, J. R., Casson, R. J., & Peet, D. J. (2024) · Bioscience Reports · doi:10.1042/bsr20231904 · Cited by 18

Retinal Manifestations of Mitochondrial Oxidative Phosphorylation Disorders

Oh, J. K., de Carvalho, J. R. L., Nuzbrokh, Y., Ryu, J., Chemudupati, T., Mahajan, V. B., Sparrow, J. R., & Tsang, S. H. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.12.12 · Cited by 17

TMEM67, TMEM237, and Embigin in Complex With Monocarboxylate Transporter MCT1 Are Unique Components of the Photoreceptor Outer Segment Plasma Membrane

Skiba, N. P., Cady, M. A., Molday, L. L., Han, J. Y. S., Lewis, T. R., Spencer, W. J., Thompson, W. J., Hiles, S., Philp, N. J., Molday, R. S., et al. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100088 · Cited by 17

Gene Therapies for Retinitis Pigmentosa that Target Glucose MetabolismPreprint

Xue, Y., & Cepko, C. L. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041289 · Cited by 17

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors

Scott, L. M., Vincent, E. E., Hudson, N., Neal, C., Jones, N., Lavelle, E. C., Campbell, M., Halestrap, A. P., Dick, A. D., & Theodoropoulou, S. (2021) · JCI Insight · doi:10.1172/jci.insight.129429 · Cited by 15

Retinal pigment epithelium lipid metabolic demands and therapeutic restoration

Nolan, N. D., Jenny, L. A., Wang, N., & Tsang, S. H. (2021) · Taiwan Journal of Ophthalmology · doi:10.4103/tjo.tjo_31_21 · Cited by 16

Prolonged Lifetimes of Histologic Autofluorescence in Ectopic Retinal Pigment Epithelium in Age-Related Macular Degeneration

Simon, R., Jentsch, M., Karimimousivandi, P., Cao, D., Messinger, J. D., Meller, D., Curcio, C. A., & Hammer, M. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.13.5 · Cited by 15

How crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration

Lakkaraju, A., Boya, P., CSETE, M. E., Ferrington, D. A., Hurley, J. B., Sadun, A. A., Shang, P., Sharma, R., Sinha, D., Ueffing, M., et al. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.110219 · Cited by 14

Metabolomics and Biomarkers in Retinal and Choroidal Vascular Diseases

Hou, X.-W., Wang, Y., Ke, C., Li, M., & Pan, C. (2022) · Metabolites · doi:10.3390/metabo12090814 · Cited by 14

Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration

Weh, E., Goswami, M. T., Chaudhury, S., Fernando, R., Miller, N., Hager, H. M., Sheskey, S., Sharma, V., Wubben, T. J., & Besirli, C. G. (2023) · Cells · doi:10.3390/cells12162043 · Cited by 14

Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa

Lee, S. J., Emery, D., Vukmanic, E. V., Wang, Y., Lu, X., Wang, W., Fortuny, E. M., James, R. F., Kaplan, H. J., Liu, Y., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113054 · Cited by 15

The many faces of SIRT6 in the retina and retinal pigment epithelium

Cheng, J., Keuthan, C. J., & Esumi, N. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1244765 · Cited by 14

CRISPR editing of anti-anemia drug target rescues independent preclinical models of retinitis pigmentosa

Nolan, N. D., Cui, X., Robbings, B. M., Demirkol, A., Pandey, K., Wu, W.-H., Hu, H. F., Jenny, L. A., Lin, C., Hass, D. T., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101459 · Cited by 19

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

Murenu, E., Kostidis, S., Lahiri, S., Geserich, A. S., Imhof, A., Giera, M. A., & Michalakis, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052345 · Cited by 14

Reduced nuclear NAD+ drives DNA damage and subsequent immune activation in the retina

Brown, E. E., Scandura, M. J., Mehrotra, S., Wang, Y., Du, J., & Pierce, E. A. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab324 · Cited by 14

Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling

Gospe, S. M., Travis, A. M., Kolesnikov, A. V., Klingeborn, M., Wang, L., Kefalov, V. J., & Arshavsky, V. Y. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007945 · Cited by 13

Optical Gap Biomarker in Cone-Dominant Retinal Dystrophy

Oh, J. K., Ryu, J., de Carvalho, J. R. L., Levi, S. R., Lee, W., Tsamis, E., Greenstein, V. C., Mahajan, V. B., Allikmets, R. L., & Tsang, S. H. (2020) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2020.05.016 · Cited by 13

Inducible Pluripotent Stem Cells to Model and Treat Inherited Degenerative Diseases of the Outer Retina: 3D-Organoids Limitations and Bioengineering Solutions

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Expression of glucose transporter‐2 in murine retina: Evidence for glucose transport from horizontal cells to photoreceptor synapses

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