Glucose, lactate, and shuttling of metabolites in vertebrate retinas

Hurley, James B.; Lindsay, Kenneth J.; Du, Jianhai

doi:10.1002/jnr.23583

Cited by 275Retinal Development and DisordersNeuroscience and Neuropharmacology ResearchRetinal Diseases and Treatments

Glucose, lactate, and shuttling of metabolites in vertebrate retinas

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Hurley, James B., Lindsay, Kenneth J., Du, Jianhai·2015·Journal of Neuroscience Research

DOI 10.1002/jnr.23583PMC PMC4720126

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Abstract

The vertebrate retina has specific functions and structures that give it a unique set of constraints on the way in which it can produce and use metabolic energy. The retina's response to illumination influences its energy requirements, and the retina's laminated structure influences the extent to which neurons and glia can access metabolic fuels. There are fundamental differences between energy metabolism in retina and that in brain. The retina relies on aerobic glycolysis much more than the brain does, and morphological differences between retina and brain limit the types of metabolic relationships that are possible between neurons and glia. This Mini-Review summarizes the unique metabolic features of the retina with a focus on the role of lactate shuttling.

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In the retina, photoreceptors perform aerobic glycolysis and export lactate, which is then oxidized by Müller cells.
“the opposite appears to be true: photoreceptors perform aerobic glycolysis and export lactate, which is then oxidized by Müller cells (Hurley et al., 2015; Kanow et al., 2017).”
From Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism (2018) · cites this paper as Hurley et al., 2015

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Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
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“…of the retina (Müller cells) might supply lactate to photoreceptors (Poitry-Yamate et al., 1995; Hurley et al., 2015), the opposite appears to be true: photoreceptors perform aerobic glycolysis and export lactate, which is then oxidized by Müller cells (Hurley et al., 2015; Kanow et al., 2017).”
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Glycolytic reliance promotes anabolism in photoreceptors
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Authors: Hurley, J. B., Lindsay, K. J., & Du, J.
Affiliations: University of Washington (US)
Departments of Biochemistry and Ophthalmology University of Washington Seattle Washington
Corresponding author: Hurley, James B.
ORCID: Hurley, James B.
Du, Jianhai
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2015-03-20
Volume: 93
Issue: 7
Pages: 1079-1092
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.23583
PMC: PMC4720126
OpenAlex: W1555812953
Cited by: 275
References: 98
Citations by year: 2026: 29 · 2025: 37 · 2024: 37 · 2023: 21 · 2022: 28 · 2021: 28 · 2020: 30 · 2019: 19 · 2018: 18 · 2017: 15 · 2016: 10 · 2015: 3
FWCI: 1.49
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (EY017863)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Keywords: retinal energy metabolism, glucose metabolism, lactate shuttle, aerobic glycolysis, retinal neurons, retinal glia
MeSH terms: Animals, Energy Metabolism, Glucose, Humans, Retina, Vertebrates, Lactic Acid

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Glucose, lactate, and shuttling of metabolites in vertebrate retinas

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