Cited by 274Gut microbiota and healthDrug Transport and Resistance MechanismsOral microbiology and periodontitis research

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A selective gut bacterial bile salt hydrolase alters host metabolism

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Yao, Lina, Seaton, Sarah Craven, Ndousse-Fetter, Sula, Adhikari, Arijit A, DiBenedetto, Nicholas, Mina, Amir I, Banks, Alexander S, Bry, Lynn, Devlin, A Sloan·2018·eLife

DOI 10.7554/elife.37182PMC PMC6078496

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Abstract

The human gut microbiota impacts host metabolism and has been implicated in the pathophysiology of obesity and metabolic syndromes. However, defining the roles of specific microbial activities and metabolites on host phenotypes has proven challenging due to the complexity of the microbiome-host ecosystem. Here, we identify strains from the abundant gut bacterial phylum Bacteroidetes that display selective bile salt hydrolase (BSH) activity. Using isogenic strains of wild-type and BSH-deleted Bacteroides thetaiotaomicron, we selectively modulated the levels of the bile acid tauro-β-muricholic acid in monocolonized gnotobiotic mice. B. thetaiotaomicron BSH mutant-colonized mice displayed altered metabolism, including reduced weight gain and respiratory exchange ratios, as well as transcriptional changes in metabolic, circadian rhythm, and immune pathways in the gut and liver. Our results demonstrate that metabolites generated by a single microbial gene and enzymatic activity can profoundly alter host metabolism and gene expression at local and organism-level scales.

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Additional file 1 of Comparative genome analysis of commensal segmented filamentous bacteria (SFB) from turkey and murine hosts reveals distinct metabolic features
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Authors: Yao, L., Seaton, S. C., Ndousse-Fetter, S., Adhikari, A. A., DiBenedetto, N., Mina, A. I., Banks, A. S., Bry, L., & Devlin, A. S.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Corresponding author: Devlin, A Sloan
ORCID: Yao, Lina
DiBenedetto, Nicholas
Mina, Amir I
Banks, Alexander S
Bry, Lynn
Devlin, A Sloan
Venue: eLife
Publisher: eLife Sciences Publications, Ltd
Published: 2018-07-17
Volume: 7
ISSN: 2050-084X (ISSN-L)
DOI: 10.7554/elife.37182
PMC: PMC6078496
OpenAlex: W2884910880
Cited by: 274
References: 90
Citations by year: 2026: 28 · 2025: 33 · 2024: 41 · 2023: 28 · 2022: 45 · 2021: 41 · 2020: 32 · 2019: 23 · 2018: 3
FWCI: 8.81
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
creativecommons.org/licenses/by/4.0/ (am)
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: eLife (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health (P30DK034854)
Wellington Postdoctoral Fellowship
Massachusetts Institute of Technology (Center for Microbiome Informatics and Therapeutics – Innovation Award)
Karin Grunebaum Cancer Research Foundation (Junior Faculty Award)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: bile salt hydrolase, Bacteroides thetaiotaomicron, gut microbiota, host metabolism, bile acids, obesity, metabolic syndrome, gnotobiotic mice, respiratory exchange ratio, circadian rhythm, immune gene expression, microbial metabolites
MeSH terms: Bacteroides thetaiotaomicron, Host Microbial Interactions, Amidohydrolases, Animals, Body Weight, Circadian Rhythm, Germ-Free Life, Immunity, Intestines, Liver, Metabolism, Respiration, Taurocholic Acid, Gene Expression Profiling, Gastrointestinal Tract, Mice

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A selective gut bacterial bile salt hydrolase alters host metabolism

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