Bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe-host crosstalk
Open accessAbstract
Controlled, reductionist approaches are required in order to obtain a more complete understanding of the functional capabilities of the gut microbiota. We recently identified microbial bile salt hydrolase (BSH) activity as a gut microbial activity that has the capacity to profoundly alter both local (gastrointestinal) and systemic (hepatic) host functions. Using both germ free and conventionally-raised mouse models we demonstrated that gastrointestinal expression of BSH results in local bile acid deconjugation with concomitant alterations in lipid and cholesterol metabolism, signaling functions and weight gain. Key mediators of cholesterol homeostasis (Abcg5/8), gut homeostasis (RegIIIγ) and circadian rhythm (Dbp) were influenced by elevated BSH in our study. In this addendum we discuss the implications of this work for the rational development of probiotics with the potential to modulate host weight gain.
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This process implies a downregulation of the nuclear farnesoid X receptor/fibroblast growth factor-19 feedback loop in humans.
“This process implies a downregulation of key regulators of energy and lipid metabolism such as the nuclear farnesoid X receptor (FXR)/fibroblast growth factor-19 (FGF-19) feedback loop in humans (FXR/FGF-15 in mice).17”
From <i>Lactiplantibacillus plantarum</i> strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans (2024) · cites this paper as [17]
The References section cites a mouse study reporting downregulation of the FXR–FGF15 axis, and the ‘Potential Effectors in our System’ section lists that axis among possible effects. Our copy does not establish that the process downregulates an FXR–FGF19 feedback loop in humans; it describes the authors’ BSH findings in mice and treats other metabolic effects as potential mechanisms. No page number is available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredBile salt hydrolase deconjugates bile salts, which are then poorly absorbed, inducing activation of de novo synthesis of bile salts in the liver, leading to higher mobilization of cholesterol stores and promoting reduction of plasma cholesterol levels.
“BSH deconjugates bile salts, which are then poorly absorbed, inducing the activation of de novo synthesis of bile salts in the liver, leading to higher mobilization of cholesterol stores, and promoting the reduction of plasma cholesterol levels.17”
From <i>Lactiplantibacillus plantarum</i> strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans (2024) · cites this paper as [17]
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Experimental — accuracy not yet measuredBile salt hydrolase activity could influence lipid metabolism and cholesterol levels in the host through the activation of specific signalling pathways.
“This activity could influence lipid metabolism and cholesterol levels in the host through the activation of specific signalling pathways.14,17”
From <i>Lactiplantibacillus plantarum</i> strains KABP011, KABP012, and KABP013 modulate bile acids and cholesterol metabolism in humans (2024) · cites this paper as [17]
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- Authors
- Joyce, S. A., Shanahan, F., Hill, C., & Gahan, C. G.
- Affiliations
- University College Cork (IE)
- Corresponding author
- Gahan, Cormac GM
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2014-09-03
- Volume
- 5
- Issue
- 5
- Pages
- 669-674
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC4615832
- OpenAlex
- W2005568265
- Cited by
- 139
- References
- 53
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 14 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 18 · 2019: 14 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 4
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Research Board
- Science Foundation Ireland (SFI/12/RC/, 12/RC/2273, 12/RC/, SFI/12/RC/2273.)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- bile salt hydrolase, gut microbiota, bile acid deconjugation, cholesterol metabolism, lipid metabolism, RegIIIγ, DBP, circadian rhythm, weight gain, probiotics, host-microbe crosstalk, germ-free mice
- MeSH terms
- Amidohydrolases, Animals, Bacteria, Bacterial Proteins, Body Weight, Cholesterol, Circadian Rhythm, Models, Animal, Gastrointestinal Tract, Mice
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