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Cited by 170Congenital heart defects researchHippo pathway signaling and YAP/TAZDevelopmental Biology and Gene Regulation

Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

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Duchemin, Anne-Laure, Vignes, Hélène, Vermot, Julien·2019·eLife
DOI 10.7554/elife.44706PMC PMC6779468

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Abstract

Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, albeit active in different cell layers. Furthermore, we show that Piezo and TRP mechanosensitive channels are important factors modulating these pathways. In addition, live reporters reveal that Piezo controls Klf2 and Notch activity in the endothelium and Yap1 localization in the smooth muscle progenitors to coordinate OFT valve morphogenesis. Together, this work identifies a unique morphogenetic program during OFT valve formation and places Piezo as a central modulator of the cell response to forces in this process.

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  • Piezo1 acts as the major mechanosensor sensing fluid shear stress during EndMT in mouse.

    “suggesting it acts as the major mechanosensor sensing fluid shear stress during EndMT in mouse, as is observed in zebrafish13,49”

    From Cell diversity and plasticity during atrioventricular heart valve EMTs (2023) · cites this paper as [49]

    The Discussion section on Piezo and OFT cell identity suggests that Piezo1 might help activate a shear-stress response in zebrafish outflow-tract endothelium. It presents shear sensing as a hypothesis, however, and does not establish Piezo1 as the major mechanosensor during EndMT in mice. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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References 91 · Cited by 170

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Authors
Duchemin, A.-L., Vignes, H., & Vermot, J.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Vermot, Julien
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2019-09-16
Volume
8
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.44706
PMC
PMC6779468
OpenAlex
W2974614060
Cited by
170
References
91
Citations by year
2026: 16 · 2025: 17 · 2024: 36 · 2023: 24 · 2022: 26 · 2021: 27 · 2020: 19 · 2019: 5
FWCI
6.37
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Spiral (Imperial College London) (submittedVersion)
Funders
  • H2020 European Research Council (682938 - EVALVE)
  • Fondation pour la Recherche Médicale (DEQ29553)
  • Agence Nationale de la Recherche (ANR-15-CE13-0015-01, ANR-10-IDEX-0002-02, ANR-12-ISV2-0001-01, ANR-10-LABX-0030-INRT)
  • European Molecular Biology Organization (Young Investigator Program)
  • Fondation Lefoulon Delalande
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
Piezo channels, mechanosensing, heart valve development, YAP, KLF2, Notch signaling, Hippo signaling pathway, TRP channels, endothelium, zebrafish
MeSH terms
YAP-Signaling Proteins, Animals, Heart Valves, Ion Channels, Stress, Mechanical, Zebrafish, Signal Transduction, Trans-Activators, Zebrafish Proteins, Kruppel-Like Transcription Factors, Receptors, Notch

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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