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Cited by 33Developmental Biology and Gene RegulationTGF-β signaling in diseasesHippo pathway signaling and YAP/TAZ

Muscle-derived Myoglianin regulates Drosophila imaginal disc growth

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Upadhyay, Ambuj, Peterson, Aidan J, Kim, Myung-Jun, O'Connor, Michael B·2020·eLife
DOI 10.7554/elife.51710PMC PMC7371420

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Abstract

Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In Drosophila, the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFβ/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.

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  • Myoglianin in Drosophila conveys information on body size to imaginal discs so that their growth is appropriate for that of the body.

    “It conveys information on body size to imaginal discs so that their growth is appropriate for that of the body [63].”

    From Regulation of metamorphosis in holometabolous insects (2026) · cites this paper as [63]

    The Discussion (page unavailable) says muscle-derived Myoglianin acts systemically to fine-tune imaginal disc growth. It proposes that this may help scale appendages to the muscles that move them, but does not establish that Myoglianin conveys body-size information to discs or ensures their growth matches body size. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Upadhyay, A., Peterson, A. J., Kim, M.-J., & O'Connor, M. B.
Affiliations
  • University of Minnesota (US)
  • Department of Genetics, Cell Biology and Development University of Minnesota, Minneapolis, United States
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2020-07-07
Volume
9
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.51710
PMC
PMC7371420
OpenAlex
W3040659274
Cited by
33
References
3
Citations by year
2026: 6 · 2025: 4 · 2024: 10 · 2023: 5 · 2022: 5 · 2021: 1 · 2020: 2
FWCI
1.05
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institute of General Medical Sciences (R35GM118029)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords
myostatin, TGF-beta signaling, wing size, Drosophila
MeSH terms
Animals, Drosophila melanogaster, Larva, Muscles, Signal Transduction, Transforming Growth Factor beta, Drosophila Proteins, Smad Proteins, Receptor-Regulated, Imaginal Discs

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