The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment
Open accessAbstract
Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in bone homeostasis and diseases such as osteoporosis. While it is long postulated that they originate from mesenchymal stem cells, the true identity of progenitors and their in vivo bifurcated differentiation routes into osteoblasts and adipocytes remain poorly understood. Here, by employing large scale single cell transcriptome analysis, we computationally defined mesenchymal progenitors at different stages and delineated their bi-lineage differentiation paths in young, adult and aging mice. One identified subpopulation is a unique cell type that expresses adipocyte markers but contains no lipid droplets. As non-proliferative precursors for adipocytes, they exist abundantly as pericytes and stromal cells that form a ubiquitous 3D network inside the marrow cavity. Functionally they play critical roles in maintaining marrow vasculature and suppressing bone formation. Therefore, we name them marrow adipogenic lineage precursors (MALPs) and conclude that they are a newly identified component of marrow adipose tissue.
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Citations
Cites
Integrating single-cell transcriptomic data across different conditions, technologies, and species
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A perivascular origin for mesenchymal stem cells in multiple human organs
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BackgroundSelf-citationPericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
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BackgroundMethodInfluentialThe bone marrow microenvironment at single-cell resolution
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Self-citationIdentification of a mesenchymal progenitor cell hierarchy in adipose tissue
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Cited by
Bandyopadhyay, S., Duffy, M. P., Ahn, K. J., Sussman, J. H., Pang, M., Smith, D., Duncan, G., Zhang, I., Huang, J., Lin, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.013 · Cited by 300
Self-citationSenescent immune cells release grancalcin to promote skeletal aging
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Cellular heterogeneity in adipose tissues
Corvera, S. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-031620-095446 · Cited by 171
Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow
Liu, X., Gu, Y., Kumar, S., Amin, S., Guo, Q., Wang, J., Fang, C.-L., Cao, X., & Wan, M. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.03.005 · Cited by 137
The implications of bone marrow adipose tissue on inflammaging
Aaron, N., Costa, S., Rosen, C. J., & Qiang, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.853765 · Cited by 74
Metadata
- Authors
- Zhong, L., Yao, L., Tower, R. J., Wei, Y., Miao, Z., Park, J., Shrestha, R., Wang, L., Yu, W., Holdreith, N., Huang, X., Zhang, Y., Tong, W., Gong, Y., Ahn, J., Susztak, K., Dyment, N., Li, M., Long, F., Chen, C., Seale, P., & Qin, L.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2020-04-14
- Volume
- 9
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W3015701917
- Cited by
- 335
- References
- 10
- FWCI
- 19.13
- Type
- journal article
- Language
- en
- Open access
- gold
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