Framework for advancing rigorous research
Open accessAbstract
There is a pressing need to increase the rigor of research in the life and biomedical sciences. To address this issue, we propose that communities of 'rigor champions' be established to campaign for reforms of the research culture that has led to shortcomings in rigor. These communities of rigor champions would also assist in the development and adoption of a comprehensive educational platform that would teach the principles of rigorous science to researchers at all career stages.
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Numerous reports that decry failures to replicate findings in behavioral and clinical neuroscience have triggered increased emphasis on the importance of replication.
“Numerous reports that decry failures to replicate findings in behavioral and clinical neuroscience have triggered increased emphasis on the importance of replication [1-5].”
From A feature and not a bug: Replication failures can lead to new biology (2026) · cites this paper as [3]
The Abstract (page not provided) calls for greater rigor in life and biomedical research and describes a neuroscience-focused workshop on improving research practices. It does not say that numerous reports of failed replications in behavioral and clinical neuroscience triggered an increased emphasis on replication. (LLM, conf=0.73)
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Cited by
Sorted by citations
A feature and not a bug: Replication failures can lead to new biology
Marder, E. (2026) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2026.103268
- Authors
- Koroshetz, W. J., Behrman, S., Brame, C. J., Branchaw, J. L., Brown, E. N., Clark, E. A., Dockterman, D., Elm, J. J., Gay, P. L., Green, K. M., Hsi, S., Kaplitt, M. G., Kolber, B. J., Kolodkin, A. L., Lipscombe, D., MacLeod, M. R., McKinney, C. C., Munafò, M. R., Oakley, B., Olimpo, J. T., Percie du Sert, N., Raman, I. M., Riley, C., Shelton, A. L., Uzzo, S. M., Crawford, D. C., & Silberberg, S. D.
- Affiliations
- National Institute of Neurological Disorders and Stroke (US)
- iBiology, San Francisco, United States
- Vanderbilt University (US)
- University of Wisconsin–Madison (US)
- Massachusetts General Hospital (US)
- Brandeis University (US)
- Harvard University (US)
- Medical University of South Carolina (US)
- Planetary Science Institute (US)
- University of Michigan (US)
- Concord Consortium (US)
- Weill Cornell Medicine (US)
- Duquesne University (US)
- Johns Hopkins University (US)
- Brown University (US)
- University of Edinburgh (GB)
- Georgetown University Medical Center (US)
- MRC Integrative Epidemiology Unit, School of Psychological Science, University of Bristol, Bristol, United Kingdom
- Oakland University (US)
- The University of Texas at El Paso (US)
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), London, United Kingdom
- Northwestern University (US)
- Complexly, Missoula, United States
- New York Hall of Science (US)
- Corresponding author
- Crawford, Devon C
- Silberberg, Shai D
- ORCID
- Koroshetz, Walter J
- Behrman, Shannon
- Brame, Cynthia J
- Branchaw, Janet L
- Brown, Emery N
- Clark, Erin A
- Dockterman, David
- Gay, Pamela L
- Green, Katelyn M
- Hsi, Sherry
- Kaplitt, Michael G
- Kolber, Benedict J
- Kolodkin, Alex L
- Lipscombe, Diane
- MacLeod, Malcolm R
- McKinney, Caleb C
- Oakley, Barbara
- Olimpo, Jeffrey T
- Percie du Sert, Nathalie
- Raman, Indira M
- Shelton, Amy L
- Uzzo, Stephen Miles
- Crawford, Devon C
- Silberberg, Shai D
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2020-03-04
- Volume
- 9
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC7056268
- OpenAlex
- W3009484667
- Cited by
- 28
- References
- 4
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 6
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Explore Bristol Research (publishedVersion, public-domain)
- Bristol Research (University of Bristol) (acceptedVersion, public-domain)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Medical Research Council (MC_UU_00011/7)
- National Institute of Neurological Disorders and Stroke (R01NS055251)
- Topics
- Social Sciences › Decision Sciences › Information Systems and Management › Academic Publishing and Open Access
- Social Sciences › Decision Sciences › Information Systems and Management › Research, Science, and Academia
- Social Sciences › Safety Research › Academic integrity and plagiarism
- Keywords
- research rigor, research integrity, science education, biomedical sciences, research training
- MeSH terms
- Humans, Research Design, Biomedical Research
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