Effects of Five Weeks of Resistance Training and Relatively-Dosed Creatine Monohydrate Supplementation on Body Composition and Muscle Strength, and Whole-Body Creatine Metabolism in Resistance-Trained Males
Open accessAbstract
Background: Creatine (Cr) supplementation has been established as an ergogenic aid in most individuals during anaerobic exercise. However, discrepancies exist in the data when using absolute dosing. Objective: The effects of five weeks of resistance training with relatively-dosed Cr followed by four weeks of resistance training after ceasing supplementation were determined. Methods: Resistance-trained men, 19 (CR = 9, PL = 10), ingested Cr or placebo for five weeks with resistance training. Participants ingested 0.3 g/kg lean body mass/day for one week, 0.075 g/kg lean body mass/day for four weeks, with a four-week wash out. Five muscle samples, six blood samples, and nine urine samples were collected. Separate two-way ANOVAs for each criterion variable were used employing an alpha level of ≤ 0.05. Results: A group x time interaction for increased total body mass for CR Day 1 and 64 (p = 0.03) and total lean mass for CR Day 1 and 64 (p = 0.01). Group x time interactions occurred for Cr supplementation increasing serum Cr at Day 4, 8, and 22 (p = 0.03), urinary Cr at Day 4 (p = 0.01), and total muscle Cr at Day 8 (p < 0.001), 22 (p = 0.003), and 36 (p < 0.001). No significant differences occurred for serum (p = 0.14) or urine (p = 0.15) creatinine. Conclusion: Elevated levels of urinary Cr demonstrate dosing could be reduced. Keywords: Urine, creatinine, resistance training, muscle strength, serum
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Resistance-trained males who received creatine at 0.3 g/kg lean body mass/day for 7 days followed by 4 weeks at 0.075 g/kg lean body mass/day experienced no significant change in intracellular water, extracellular water, or total body water.
“For example, resistance-trained males who received creatine at a dose of 0.3 g/kg lean body mass/day for 7 days (approximately 20 g/day) followed by 4 weeks at 0.075 g/kg lean body mass/day for 28 days (approximately 5 g/day) experienced no significant change in ICW, ECW, or TBW [40].”
From Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show? (2021) · cites this paper as [40]
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The Effect of Creatine Supplementation on Lean Body Mass with and Without Resistance Training
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- Authors
- André, T., Gann, J. J., McKinley-Barnard, S. K., & Willoughby, D. S.
- Venue
- International Journal of Kinesiology and Sports Science
- Published
- 2016-05-15
- Volume
- 4
- Issue
- 2
- ISSN
- 2202-946X (ISSN-L)
- OpenAlex
- W2337935707
- Cited by
- 7
- References
- 24
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2021: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- International Journal of Kinesiology and Sports Science (publishedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Keywords
- creatine monohydrate supplementation, resistance training, body composition, lean body mass, muscle strength, urinary creatine, serum creatine, resistance-trained men
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