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Cited by 79Eating Disorders and BehaviorsNutrition, Health and Food BehaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Psychological, pharmacological, and combined treatments for binge eating disorder: a systematic review and meta-analysis

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Ghaderi, Ata, Odeberg, Jenny, Gustafsson, Sanna, Råstam, Maria, Brolund, Agneta, Pettersson, Agneta, Parling, Thomas·2018·PeerJ
DOI 10.7717/peerj.5113PMC PMC6015752
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Abstract

Objective: To systematically review the efficacy of psychological, pharmacological, and combined treatments for binge eating disorder (BED). Method: Systematic search and meta-analysis. Results: We found 45 unique studies with low/medium risk of bias, and moderate support for the efficacy of cognitive behavior therapy (CBT) and CBT guided self-help (with moderate quality of evidence), and modest support for interpersonal psychotherapy (IPT), selective serotonin reuptake inhibitors (SSRI), and lisdexamfetamine (with low quality of evidence) in the treatment of adults with BED in terms of cessation of or reduction in the frequency of binge eating. The results on weight loss were disappointing. Only lisdexamfetamine showed a very modest effect on weight loss (low quality of evidence). While there is limited support for the long-term effect of psychological treatments, we have currently no data to ascertain the long-term effect of drug treatments. Some undesired side effects are more common in drug treatment compared to placebo, while the side effects of psychological treatments are unknown. Direct comparisons between pharmaceutical and psychological treatments are lacking as well as data to generalize these results to adolescents. Conclusion: We found moderate support for the efficacy of CBT and guided self-help for the treatment of BED. However, IPT, SSRI, and lisdexamfetamine received only modest support in terms of cessation of or reduction in the frequency of binge eating. The lack of long-term follow-ups is alarming, especially with regard to medication. Long-term follow-ups, standardized assessments including measures of quality of life, and the study of underrepresented populations should be a priority for future research.

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  • In a prospective study, semaglutide decreased binge frequency and craving intensity, and improved Binge Eating Scale scores.

    “In a prospective study, Semaglutide decreased binge frequency and craving intensity, and improved Binge Eating Scale scores.”

    From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [134]

    The Results sections discuss other medications, including lisdexamfetamine and SSRIs, but no passage in our copy addresses semaglutide. Searches for semaglutide, craving intensity, and Binge Eating Scale scores did not locate the claimed prospective-study finding. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • These results were consistent in patients with moderate to severe BED, as well as in the entire sample.

    “These results were consistent in patients with moderate to severe BED, as well as in the entire sample [134].”

    From Precision obesity medicine: A phenotype-guided framework for pharmacologic therapy across the lifespan (2025) · cites this paper as [134]

    The Discussion reports treatment findings for the review sample, but does not compare those findings with results for patients with moderate-to-severe BED. Searches for severity subgroups and whole-sample comparisons found no passage establishing the claimed consistency; the Discussion’s reference to symptom severity describes the sample, not a subgroup analysis. Page numbers were not available in our copy. (LLM, conf=0.73)

    Experimental — accuracy not yet measured

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Authors
Ghaderi, A., Odeberg, J., Gustafsson, S., Råstam, M., Brolund, A., Pettersson, A., & Parling, T.
Affiliations
  • Karolinska Institutet (SE)
  • SBU - Swedish Agency for Health Technology Assessment and Assessment of Social Services (SE)
  • Örebro University (SE)
  • Lund University (SE)
  • Region Stockholm (SE)
Corresponding author
Ghaderi, Ata
ORCID
Venue
PeerJ
Publisher
PeerJ
Published
2018-06-21
Volume
6
Pages
e5113
ISSN
2167-8359 (ISSN-L)
DOI
10.7717/peerj.5113
PMC
PMC6015752
OpenAlex
W2808770184
Cited by
79
References
99
Citations by year
2026: 2 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 14 · 2021: 16 · 2020: 11 · 2019: 5 · 2018: 3
FWCI
1.47
Type
journal article
Language
en
Open access
Licence
Locations
  • PeerJ (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
Swedish Agency for Health Technology Assessment, and Assessment of Social Services
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
binge eating disorder, cognitive behavioral therapy, guided self-help, interpersonal psychotherapy, selective serotonin reuptake inhibitors, lisdexamfetamine, weight loss, binge eating frequency, treatment efficacy, long-term follow-up, adverse drug reactions

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